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Arterial stiffness in inflammatory bowel disease: a systematic review and meta-analysis.

Abstract：

BACKGROUND:Arterial stiffness is increased with chronic inflammatory disorders. The reduction of inflammation by immunomodulatory therapy is associated with a restoration of arterial function. The aims of the study were to perform a meta-analysis to determine whether arterial stiffness is increased in patients with inflammatory bowel disease (IBD) and a meta-regression analysis to correlate arterial stiffness with anti-TNFα therapy. METHODS:Systematic review registration number: CRD42015017364. A systematic literature search for arterial stiffness in IBD was performed using PubMed, Scopus, and Google Scholar databases (last accessed on 23 September 2015). The search terms were 'arterial stiffness,' 'vascular stiffness,' or 'pulse wave velocity' in combination with 'inflammatory bowel disease,' 'inflammatory bowel diseases,' 'Crohn's disease,' or 'ulcerative colitis.' Inclusion criteria included peer-reviewed publications reporting original data, a minimum of 20 study participants tested, and pulse wave velocity (PWV) measured via validated devices. Publications with titles or abstracts appearing to meet the inclusion criteria were selected and reviewed by two authors according to PRISMA 2009 guidelines. RESULTS:Carotid-femoral PWV (cf-PWV) was measured in nine cross-sectional studies (234 patients with Crohn's disease, 342 with ulcerative colitis, and 435 control study participants). Compared with control patients, cf-PWV was significantly increased in patients with Crohn's disease [mean difference 1.34 z-score; 95% confidence interval (CI) 0.71-1.97 z-score; P < 0.0001] and ulcerative colitis (mean difference 1.08 z-score; 95% CI 0.55-1.61 z-score; P < 0.0001). In a meta-regression analysis, cf-PWV was reduced in IBD patients treated with anti-TNFα therapy (β -2.6 m/s; 95% CI -4.9 to -0.2 m/s; P = 0.03). CONCLUSION:cf-PWV is increased in both ulcerative colitis and Crohn's disease patients.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Zanoli L,Rastelli S,Granata A,Inserra G,Empana JP,Boutouyrie P,Laurent S,Castellino P

doi

10.1097/HJH.0000000000000867

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

822-9

issue

eissn

0263-6352

issn

1473-5598

journal_volume

pub_type

杂志文章,meta分析

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Arterial stiffness in inflammatory bowel disease: a systematic review and meta-analysis.