Draft genome sequence of Streptomyces hyaluromycini MB-PO13T, a hyaluromycin producer.

Abstract:

:Streptomyces hyaluromycini MB-PO13T (=NBRC 110483T = DSM 100105T) is type strain of the species, which produces a hyaluronidase inhibitor, hyaluromycin. Here, we report the draft genome sequence of this strain together with features of the organism and generation, annotation and analysis of the genome sequence. The 11.5 Mb genome of Streptomyces hyaluromycini MB-PO13T encoded 10,098 putative ORFs, of which 5317 were assigned with COG categories. The genome harbored at least six type I PKS clusters, three type II PKS gene clusters, two type III PKS gene clusters, six NRPS gene clusters, and one hybrid PKS/NRPS gene cluster. The type II PKS gene cluster including 2-amino-3-hydroxycyclopent-2-enone synthetic genes was identified to be responsible for hyaluromycin synthesis. We propose the biosynthetic pathway based on bioinformatic analysis.

journal_name

Stand Genomic Sci

authors

Harunari E,Komaki H,Ichikawa N,Hosoyama A,Kimura A,Hamada M,Igarashi Y

doi

10.1186/s40793-017-0286-7

subject

Has Abstract

pub_date

2018-01-11 00:00:00

pages

2

issn

1944-3277

pii

286

journal_volume

13

pub_type

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