Abstract:
OBJECTIVE:Our objective is to determine the value of enhanced substantia nigra echo in the diagnosis of Parkinson's disease by analyzing the intensity and area of substantia nigra echo by transcranial Doppler sonography (TCS). PATIENTS AND METHODS:36 patients diagnosed as ultra early stage Parkinson's disease between 2013 November and 2014 August were selected as the disease group, and 32 healthy people with the similar representation of age and gender were selected as the control group. TCS was used to detect the echo intensity and the echo intensity of the same location of bilateral hemicerebrum was used to evaluate the bilateral substantia nigra echo. The age and gender were also used for correlation analysis with the results of substantia nigra echo. RESULTS:In the control group, there were 17 patients of substantia nigra echo grade I (53.1%), 13 cases of substantia nigra echo grade II (40.6%), 2 cases of substantia nigra echo grade III (6.3%). While in the disease group, there were 4 cases of substantia nigra echo grade II (11.1%), 13 cases of substantia nigra echo grade III (36.1%), 12 cases of substantia nigra echo grade IV (33.3%) and 7 cases of substantia nigra echo grade V (19.4%). The ratio of enhanced substantia nigra echo in Parkinson's disease patients was significantly higher than the control group. The analysis of the factors related to motor symptoms in Parkinson's disease patients revealed that the area of bilateral substantia nigra echo was negatively correlated with gender, but positively correlated with age, S/M ratio and UPDRS II score. However, there was no correlation with H-Y stage. The sensitivity of substantia nigra echo in diagnosing Parkinson's disease was 32/36=88.89% and the specificity was 30/32 = 93.75%. CONCLUSIONS:Analysis of substantia nigra echo is practically useful for the diagnosis of the ultra early stage Parkinson's disease, which can potentially improve the accuracy of clinical diagnosis to significantly enhance the early clinical prevention and reduce later disability.
journal_name
Eur Rev Med Pharmacol Scijournal_title
European review for medical and pharmacological sciencesauthors
Zhuang JJ,Zheng YH,Xu XW,Zhou Lsubject
Has Abstractpub_date
2015-12-01 00:00:00pages
4621-6issue
23eissn
1128-3602issn
2284-0729journal_volume
19pub_type
杂志文章abstract:OBJECTIVE:Platelet hyper-reactivity is one of the most important causes of accelerated atherosclerosis and increased risk of thrombotic vascular events associated with type 2 diabetes mellitus (T2DM). This study aimed to investigate the effects of different add-on anti-diabetic therapies on platelet function in T2DM pa...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Clubfoot is a complex congenital three-dimensional foot deformity, which affects 150,000-200,000 newborn babies annually around the world. A good understanding of the alignment of the two osseous columns and the lower leg of the ankle and foot complex is essential for evaluating the severity of clubfoot. The ...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:10.26355/eurrev_201903_17225
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:Breast conserving surgery (BCS) followed by radiotherapy is the standard of care for most patients with early breast cancers; however, the aesthetic outcomes of this procedure is not always desirable. Oncoplastic breast surgery is an innovative approach that aims at the safe and effective treatment of the can...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:To investigate the risk factors related to mortality in severe polytrauma patients with acute hypoxemic respiratory failure (AHRF). PATIENTS AND METHODS:From December 2011 to December 2014, we identified and intubated 524 traumatic AHRF patients in a level 1 trauma centers. Amongst those, we enrolled seventy...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:To elucidate the biological functions of long non-coding RNA (lncRNA) SNHG7 in breast cancer (BC), and its underlying mechanism in the occurrence and progression of BC. PATIENTS AND METHODS:The expression of SNHG7 in 72 pairs of BC tissues and paracancerous tissues was detected by quantitative Real-time poly...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:10.26355/eurrev_201811_16403
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:The fractional laser and topical retinoic acid treatment have been applied for skin rejuvenation; however, the possible molecular mechanism of promoting remodeling of dermis is not clearly. Here we aimed to compare the effects of 10600 nm CO2 fractional laser and topical retinoic acid formulation on the skin ...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:Laryngeal cancer is a common malignant tumor in the head and neck, which affects swallowing, breathing, and pronunciation function. In recent years, many long non-coding RNAs (lncRNAs) have been shown to be involved in the progression of cancer with the development of gene sequencing, transcriptomics, and bio...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:10.26355/eurrev_201804_14723
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:It is increasingly recognized that a low grade of systemic inflammation occurs in patients with advanced chronic obstructive pulmonary disease (COPD). C-reactive protein (CRP), a marker of systemic chronic inflammatory response, has been related with decreased survival in large cohorts of COPD...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:
更新日期:2011-09-01 00:00:00
abstract::We have recently designed a new type of walker for those severely disabled patients who cannot walk with commonly used medical walkers. A drawing and the description of this new walker is reported in order to permit the worldwide companies as well as artisans to develop and produce it for the people affected from seve...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Methicillin-resistant Staphylococcus aureus (MRSA) has been a serious problem as its infection is associated with higher mortality and increase cost worldwide. In the present study, the antibacterial activity of enhydrin, polymatin B, allo-schkuhriolide from the leaves of Smallanthus sonchifol...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVE:In this study, we investigated whether circulating microRNA-137 (miR-137) could be a potential biomarker for patients with glioblastoma (GBM). PATIENTS AND METHODS:Serum samples were collected from 64 GBM patients and 64 healthy controls. The expression level of circulating miR-137 was compared by quantitati...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:
更新日期:2016-09-01 00:00:00
abstract::A pharmacokinetic-pharmacodynamic (PK-PD) model was developed to simulate the plasma profile and the toxicity of vinorelbine after multiple oral dose treatment to humans. The PK drug profile was described by a three-compartment open model linked to a PD model aimed to describe the drug toxicity on the circulating neut...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:
更新日期:2007-11-01 00:00:00
abstract::Hunter syndrome or mucopolysaccharidosis II (MPS II) is a rare X-linked disease caused by a deficiency of the iduronate-2-sulphatase (12S) lysosomal enzyme, resulting in a progressive accumulation of glycosaminoglycans (GAGs). Enzyme replacement therapy (ERT) with recombinant human 12S idursulfase has been used infreq...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:Orolingual angioedema (OA) is a rare clinical complication with a potentially fatal risk that occurs after the intravenous application of alteplase (rt-PA) in patients with acute ischemic stroke. The purpose of this work is to investigate the related factors of OA in patients with acute ischemic stroke after ...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:10.26355/eurrev_201803_14496
更新日期:2018-03-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:This study aims to investigate the contribution of presynaptic nicotinic acetylcholine receptors (nAChRs) sub-types to nicotine-induced enhancement in electrical field stimulation (EFS) EFS-mediated contractile responses in rabbit urine bladder smooth muscle preparations. MATERIALS AND METHODS:Rabbit urine b...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:To elucidate the function of miRNA-138-5p in the early diabetic retinopathy (DR) and the potential mechanism. MATERIALS AND METHODS:DR model in rats was first established by streptozotocin (STZ) injection. MiRNA-138-5p expression in rat retinal tissues was determined by quantitative Real Time-Polymerase Chai...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:10.26355/eurrev_201909_18984
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:To investigate the regulatory effect of miR-328 on biological behaviors of hepatocellular carcinoma (HCC) cells, such as invasion and proliferation. PATIENTS AND METHODS:The expressions of miR-328 were detected in 48 pairs of HCC tissue samples and matched adjacent tissues, as well as in 3 kinds of HCC cell ...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:10.26355/eurrev_201810_16043
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:To explore whether micro ribonucleic acid (miR)-7 affects the resistance of breast cancer cells to adriamycin (ADR) through regulating the epidermal growth factor receptor (EGFR)/phosphatidylinositol 3-hydroxy kinase (PI3K) signaling pathway. MATERIALS AND METHODS:MiR-7 expression was compared among MCF-10A,...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:10.26355/eurrev_201906_18195
更新日期:2019-06-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:10.26355/eurrev_202010_23396
更新日期:2020-10-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章,评审
doi:
更新日期:2013-12-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:10.26355/eurrev_202010_23407
更新日期:2020-10-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:Phyllodes Tumor is a rare fibroepithelial breast tumor with variable malignant potential. These tumors that currently accepted nomenclature are benign, borderline and malignant according to the World Health Organization. It tends to behave in a benign way but it may undergo a malignant transformation. The pur...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Nasopharyngeal carcinoma (NPC) is a common cancer with high incidence in Southern China. Taxol is one of the first-line chemotherapeutic drugs for treating NPC; however, Taxol resistance has become the main difficulty for clinical treatment and the mechanisms remain not fully understood. In this study, we mai...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:10.26355/eurrev_202101_24375
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVES:To investigate the temporomandibular joint (TMJ) characteristics of patients who have temporomandibular disorder complaints with multislice computed tomography imaging. PATIENTS AND METHODS:Between January 2011 and March 2012, 37 patients whose age ranged from 18 to 60 years underwent Computed tomography im...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:
更新日期:2012-12-01 00:00:00
abstract::NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) inflammasome has recently become an intriguing target of several chronic and viral diseases. Here, we argue that targeting NLRP3 inflammasome could be a strategy to prevent cardiovascular outcomes [fulminant myocarditis, heart failure, venous thromboembolism (VT...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:10.26355/eurrev_202009_22867
更新日期:2020-09-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:10.26355/eurrev_202012_23991
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVES:The diagnosis of lung cancer remains a clinical challenge. Many studies have assessed the diagnostic potential of anti-p53 antibody in lung cancer patients but with controversial results. This study aims to summarize the overall diagnostic performance of anti-p53 antibody in lung cancer. MATERIALS AND METHO...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章,meta分析
doi:
更新日期:2013-11-01 00:00:00