Abstract：
OBJECTIVE:In this study, we investigated whether circulating microRNA-137 (miR-137) could be a potential biomarker for patients with glioblastoma (GBM). PATIENTS AND METHODS:Serum samples were collected from 64 GBM patients and 64 healthy controls. The expression level of circulating miR-137 was compared by quantitative RT-PCR. Among GBM patients, circulating miR-137 was compared between patients at early stages and those at advanced stages. Also, the correlations of serum miR-137 expression with clinicopathological features and overall survival of GBM patients were statistically examined. Furthermore, whether circulating miR-137 could serve as an independent predicting biomarker GBM patients' survival was assessed. RESULTS:Serum miR-137 was downregulated in GBM patients than in healthy controls. It was further downregulated in GBM patients at advanced stages than in patients at early stages. Statistical analysis demonstrated that low serum miR-137 level was strongly correlated with patients' clinical grades (p = 0.003) and KFS (p = 0.002). Low serum miR-137 was also found to be significantly correlated with, and may predict poor survival in GBM patients. CONCLUSIONS:Downregulated serum miR-137 may be a potential non-invasive prognostic biomarker for poor prognosis in GBM patients.
journal_name
Eur Rev Med Pharmacol Scijournal_title
European review for medical and pharmacological sciencesauthors
Li HY,Li YM,Li Y,Shi XW,Chen Hsubject
Has Abstractpub_date
2016-09-01 00:00:00pages
3599-604issue
17eissn
1128-3602issn
2284-0729journal_volume
20pub_type
杂志文章abstract：OBJECTIVE:Osteoradionecrosis (ORN) is a bone aseptic necrosis which develops on post-irradiated bone tissue of patients who underwent radiotherapy for head-neck tumors. The mandible presents a higher risk to develop ORN, if compared to the maxillary bone, due to its lower vascularization. The aim of the present study i...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVES:Echinococcosis infection is caused in humans by the larval stage of cestodes belonging to the genus Echinococcus. Hydatid cyst cured by percutaneous aspiration, infusion of scolicidal agents with reaspiration or surgery. Many scolicidal agents have been used for inactivation of the cyst's content, but most o...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：
更新日期：2013-07-01 00:00:00
abstract：OBJECTIVE:Vorinostat is a drug used to treat cutaneous T cell lymphoma whose action mechanism is based on Histone Deacetylase inhibition. Histone Deacetylases are a family of enzymes that remove acetyl groups from histone and non-histone proteins that control many crucial processes, such as gene regulation, cell cycle ...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_202007_21909
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVE:Recent researches have proved that long noncoding RNAs (lncRNAs) cover an important role in malignant tumors. Our study showed how lncRNA myocardial infarction-associated transcript (MIAT) functions in the development of Wilms' tumor. PATIENTS AND METHODS:Real Time-quantitative Polymerase Chain Reaction (RT-...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_201912_19663
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVE:To elucidate whether long non-coding RNA (lncRNA) Bmncr could inhibit RANML-induced osteoclast differentiation, thus alleviating the progression of osteoporosis. MATERIALS AND METHODS:Expression level of lncRNA Bmncr at different stages of osteoclast differentiation was detected by quantitative Real Time-Pol...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_201911_19411
更新日期：2019-11-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to investigate the effects of oxaliplatin on intestinal floras, inflammation level, apoptosis-related gene expressions and oxidative stress in rats with colorectal cancer. MATERIALS AND METHODS:A total of 30 adult Sprague-Dawley (SD) rats were selected as research objects and were d...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_202010_23407
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVE:Long non-coding RNA (lncRNA) LINC00858 has been found to exert oncogenic activity in several types of cancers, except gastric cancer (GC). In the present study, we aimed to explore the potential role of LINC00858 in GC and the underlying molecular mechanism. PATIENTS AND METHODS:The expression patterns of LI...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_202009_23022
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVE:To investigate the impact of miR-124Aa on the proliferation, invasion and cytokine excretion of rheumatoid arthritis synovial fibroblasts (RASFs) in patients with rheumatoid arthritis (RA). PATIENTS AND METHODS:RASFs were separated for in-vitro culture, and transfected using lipidosome that connected with ch...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_201807_15515
更新日期：2018-07-01 00:00:00
abstract：OBJECTIVE:The aim of this work was to explore whether lncRNA-MEG3 could serve as a serum biomarker for diagnosing chronic hepatitis B (CHB) and improve the early diagnostic and treatment efficacies. PATIENTS AND METHODS:Serum level of lncRNA-MEG3 in CHB patients and healthy controls was detected by quantitative Real T...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_201905_17943
更新日期：2019-05-01 00:00:00
abstract：:Non-Muscle-Invasive-Bladder-Cancer represents 75-85% of the new bladder cancer cases per year. Trans-uretral vesical resection is the milestone for diagnosis and therapy. After primary treatment, recurrence is frequent depending on the presence of several established risk factors: multiplicity, T dimension, prior recu...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章,评审
doi：
更新日期：2013-08-01 00:00:00
abstract：OBJECTIVE:To investigate the therapeutic effect of drug therapy with cyclophosphamide and leflunomide on the joint function damage of patients with systemic lupus erythematosus (SLE) and its regulatory effects on expression levels of programmed death receptor 1, Notch signaling pathway genes and interferon-inducible pr...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2017-10-01 00:00:00
abstract：OBJECTIVE:To investigate the effects of recombinant activated coagulation factor VII (rFVIIa) on apoptosis and the expressions of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax) in rats with intracerebral hemorrhage (ICH). MATERIALS AND METHODS:A total of 90 8-week-old male Sprague-Dawley (SD) rats with...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_201808_15725
更新日期：2018-08-01 00:00:00
abstract：OBJECTIVE:This study aims to evaluate the effect of trans-resveratrol/carboxymethylated (1.3/1.6)-β-d-glucan administered via nasal, after FESS, assessing nasal respiratory distress and nasal mucosa healing. PATIENTS AND METHODS:We enrolled 70 patients, from March 2019 to February 2020, with chronic nasal obstruction ...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_202012_24034
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVE:Although migraine has been related with an increased risk for ischemic stroke and cardiovascular events, there is insufficient data for role of pro-brain natriuretic peptide (pro-BNP) in migraine. In present case-control study, serum levels of pro-inflammatory (TNF-alpha, IL-1beta and IL-6) and anti-inflammat...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVE:It has been confirmed that the dysregulation of long noncoding RNAs (lncRNAs) is associated with various diseases, especially cancer. LncRNA MAGI2 antisense RNA 3 (MAGI2-AS3) has been reported to be involved in the progression of bladder cancer and breast cancer. In this study, we aimed to explore its express...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_201904_17710
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVE:To explore the protective role of Vitamin D Receptor (VDR) in retinal ganglion cells (RGCs) after high-level glucose induction, and to investigate its underlying mechanism. MATERIALS AND METHODS:Primary RGCs were isolated from 24-hour-old Sprague Dawley (SD) rats and cultured in 50 mmol/L glucose. The expres...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_201811_16292
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVE:Dysregulation of long non-coding RNAs (lncRNAs) is associated with human carcinogenesis. The aim of the study is to explore the biological functions of MEG3 expression in laryngeal squamous cell carcinoma (LSCC). PATIENTS AND METHODS:QRT-PCR analysis was performed to assess the expression of MEG3 in 35 pairs...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_201903_17247
更新日期：2019-03-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to investigate the effects of miR-940 and Toll-like receptor 4/Nuclear Factor κB (TLR4/NF-κB) pathways on inflammatory responses and spinal cord injury (SCI). MATERIALS AND METHODS:This study first established a model of spinal cord injury in mice. The grip force measurement was use...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_201904_17677
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVE:To explore the effective and convenient methods of infantile hemangioma treatment. PATIENTS AND METHODS:From October 2010 to June 2014, 31 infantile hemangioma patients admitted to our hospital, were administered propranolol combined with betamethasone injection treatment of lesions. RESULTS:All patients we...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVE:Sepsis refers to the systemic inflammatory response caused by infection. Acute kidney injury (AKI) in sepsis is very common, and there are many complicated mechanisms for the occurrence of septic AKI. This article aimed to study the role of miR-942-5p in inflammation and apoptosis of septic AKI and its potent...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_202006_21521
更新日期：2020-06-01 00:00:00
abstract：OBJECTIVE:To investigate the role of IL-9 in chronic obstructive pulmonary disease (COPD), and to explore its potential mechanism. MATERIALS AND METHODS:A mouse COPD model was established by exposure to cigarette smoke. COPD mice were then randomly assigned into two groups, including: the PBS group and the IL-9 antibo...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_201812_16656
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVE:Pathogenesis factor of pregnant hypertension is still unclear and lacks of effective treatment. MiR-155 is a recently discovered miRNA molecule with differential expression in pregnant hypertension, which participates in the disease regulation. As a downstream target gene of miR-155, FOXO3a is correlated with...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_201810_16133
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVE:Heart rate variability analysis of electrocardiogram is becoming an increasingly common method to non-invasively evaluate autonomic nervous function. The aim of the study was to investigate cardiac autonomic function in subjects with and without migraine by using 24-hour ambulatory electrocardiographic record...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：
更新日期：2015-10-01 00:00:00
abstract：INTRODUCTION:The hysto-morfological composition of the ascending aorta wall gives to the vessel its characteristic elasticity/distensibility, which is deteriorated due to both physiological (age) and pathological events (hypertension, diabetes, dyslipidemia). This contributes to reduce the wall elasticity and to occurr...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVE:Risk factors for implant therapy are represented by all general and local conditions that through various mechanisms can increase either short-term and long-term failure risk. The aim of this study is to assess the implant survival and implant success rates with single and multiple risk factors. PATIENTS AND...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：
更新日期：2017-02-01 00:00:00
abstract：OBJECTIVE:This study aims to detect the expression pattern of microRNA-375 in colorectal cancer (CRC), and to examine its specific mechanism in regulating the progression of CRC. PATIENTS AND METHODS:We detected microRNA-375 expression in 50 pairs of CRC and paracancerous tissues by quantitative real-time polymerase c...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_201906_18055
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVE:To detect differentially expressed micro ribonucleic acids (miRNAs) in rats with myocardial ischemia/reperfusion (MIR), and to explore the influence of miR-19a on MIR rats and its mechanism. MATERIALS AND METHODS:Firstly, the Sprague-Dawley (SD) rats were used to prepare MIR models, RNAs were extracted, and ...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_202003_20700
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:Coronary artery bypass grafting (CABG) is a revascularization technique that has been reported as having satisfactory survival rates in Hemodialysis (HD) dependent patients. AIM:The aim of this study was to determine morbidity and mortality of isolated CABG in HD-dependent patients and compare with non- ren...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVE:To study the impact on seizure frequency and epileptiform discharges of children with epilepsy from topiramate (TPM) and phenobarbital (PB). PATIENTS AND METHODS:Two hundred cases children with epilepsy from August 2010 to August 2013 in our hospital were sampled and randomly divided into two groups. The obs...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2016-03-01 00:00:00
abstract：OBJECTIVE:Vaginal atrophy is a chronic, progressive medical condition that affects fifty percent of postmenopausal women, causing symptoms like dyspareunia, vaginal dryness, and vaginal irritation. Until recently, the only prescription options were systemic and vaginal estrogen therapies that might be limited by concer...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章,评审
doi：
更新日期：2016-09-01 00:00:00
