Circulating microRNA-137 is a potential biomarker for human glioblastoma.

Abstract:

OBJECTIVE:In this study, we investigated whether circulating microRNA-137 (miR-137) could be a potential biomarker for patients with glioblastoma (GBM). PATIENTS AND METHODS:Serum samples were collected from 64 GBM patients and 64 healthy controls. The expression level of circulating miR-137 was compared by quantitative RT-PCR. Among GBM patients, circulating miR-137 was compared between patients at early stages and those at advanced stages. Also, the correlations of serum miR-137 expression with clinicopathological features and overall survival of GBM patients were statistically examined. Furthermore, whether circulating miR-137 could serve as an independent predicting biomarker GBM patients' survival was assessed. RESULTS:Serum miR-137 was downregulated in GBM patients than in healthy controls. It was further downregulated in GBM patients at advanced stages than in patients at early stages. Statistical analysis demonstrated that low serum miR-137 level was strongly correlated with patients' clinical grades (p = 0.003) and KFS (p = 0.002). Low serum miR-137 was also found to be significantly correlated with, and may predict poor survival in GBM patients. CONCLUSIONS:Downregulated serum miR-137 may be a potential non-invasive prognostic biomarker for poor prognosis in GBM patients.

authors

Li HY,Li YM,Li Y,Shi XW,Chen H

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

3599-604

issue

17

eissn

1128-3602

issn

2284-0729

journal_volume

20

pub_type

杂志文章
  • Effect of an extra-virgin olive oil enriched with probiotics or antioxidants on functional dyspepsia: a pilot study.

    abstract:BACKGROUND:While antioxidants and probiotics have been proposed for the treatment of functional dyspepsia, current data are still heterogeneous and studies are poorly designed. Extra-virgin olive oil, a common ingredient of Mediterranean diet, has shown antioxidant properties. AIMS:To evaluate the effect of extra-virg...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章,随机对照试验

    doi:

    authors: Ianiro G,Pizzoferrato M,Franceschi F,Tarullo A,Luisi T,Gasbarrini G

    更新日期:2013-01-01 00:00:00

  • Use of cognitive enhancers: methylphenidate and analogs.

    abstract:OBJECTIVE:In the last decades, several cognitive-enhancing drugs have been sold onto the drug market. Methylphenidate and analogs represent a sub-class of these new psychoactive substances (NPS). We aimed to review the use and misuse of methylphenidate and analogs, and the risk associated. Moreover, we exhaustively rev...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.26355/eurrev_201901_16741

    authors: Carlier J,Giorgetti R,Varì MR,Pirani F,Ricci G,Busardò FP

    更新日期:2019-01-01 00:00:00

  • Observation of curative effect of recombinant human basic fibroblast growth factor combined with compound polymyxin B ointment and local application of insulin on wound healing of deep second-degree burn in diabetes mellitus: a randomized study.

    abstract:OBJECTIVE:We aimed at investigating the clinical efficacy of recombinant human basic fibroblast growth factor combined with compound polymyxin B ointment and the local application of insulin on wound healing of deep second-degree burn in diabetes mellitus. PATIENTS AND METHODS:80 diabetes mellitus patients complicated...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章,随机对照试验

    doi:10.26355/eurrev_201907_18345

    authors: Zhang JB,Li H,Zhang L,Wang JL

    更新日期:2019-07-01 00:00:00

  • Anaphylaxis from peanut oil in infant feedings and medications.

    abstract::Peanut is a very dangerous allergen. Too often one is unaware that peanut allergens can be found everywhere, hidden in a myriad of foods, and without any indication of their presence. It is stressed that not even infant feedings and medications can be exempt, thus leading to anaphylaxis. ...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Cantani A

    更新日期:1998-09-01 00:00:00

  • Electrophysiological effects of melatonin on rat trigeminal ganglion neurons that participate in nociception in vitro.

    abstract:OBJECTIVE:Melatonin (MT) is a hormone mainly produced by the pineal gland. It may be involved in the regulation of nociception, the mechanisms of which remain unclear. In the present study, electrophysiological effects of MT on neurons were studied. MATERIALS AND METHODS:The cultured neurons were isolated from Sprague...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201805_15086

    authors: Huang F,Guan XY,Yan Y,Fan WG,You YY,He HW,Cheng B

    更新日期:2018-05-01 00:00:00

  • CXCL10 an important chemokine associated with cytokine storm in COVID-19 infected patients.

    abstract:OBJECTIVE:The specific mechanism of cytokine storm in COVID-19 infected patients is not clear. This study aims to identify the key genes that cause cytokine storm in COVID-19 infected patients. MATERIALS AND METHODS:We conducted a difference analysis on the GSE147507 data set. The analysis results are combined with im...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章,评审

    doi:10.26355/eurrev_202007_21922

    authors: Zhang N,Zhao YD,Wang XM

    更新日期:2020-07-01 00:00:00

  • Dehydroepiandrosterone supplementation improves ovarian reserve and pregnancy rates in poor responders.

    abstract:OBJECTIVE:We investigated whether DHEA supplementation had an impact on ovarian reserve parameters and pregnancy rates in patients with poor ovarian response (POR) and primary ovarian insufficiency (POI). PATIENTS AND METHODS:A total of 34 people, 6 patients with POI and 28 patients with POR, were included in the stud...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202009_22856

    authors: Ozcil MD

    更新日期:2020-09-01 00:00:00

  • Knockdown of FOXM1 suppresses cell growth and metastasis in human laryngeal cancer via the AKT signaling pathway.

    abstract:OBJECTIVE:This study aims to investigate the potential regulatory effect of forkhead box M1 (FOXM1) on laryngeal carcinoma (LC) and the underlying mechanisms. PATIENTS AND METHODS:Tumor tissues were obtained from 80 patients diagnosed with LC in our hospital. Quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) ...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202006_21667

    authors: Yan J,Hou J,Yan Y,Ren XY,Luo HN,Wang ZG,Zheng GX

    更新日期:2020-06-01 00:00:00

  • Effects of vitamin D levels on asthma control and severity in pre-school children.

    abstract:OBJECTIVE:Prevalence of asthma and vitamin D deficiency has been increasing and leading to significant morbidities. This study aimed to compare the vitamin D levels in the pre-school children with asthma and in healthy controls and to assess the relationship between vitamin D levels and asthma clinical parameters and c...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Turkeli A,Ayaz O,Uncu A,Ozhan B,Bas VN,Tufan AK,Yilmaz O,Yuksel H

    更新日期:2016-01-01 00:00:00

  • Mediastinal parathyroid adenoma: a case report.

    abstract::Ectopic parathyroid adenomas represent a diagnostic challenge, since they are quite rare in clinical practice. We present a case of a 61 years old man with symptomatic hypercalcemia due to an ectopic parathyroid adenoma in the upper-anterior mediastinum that was not localized by the scintigraphy. Ultrasonography ident...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Di Cosimo C,Metere A,Chiesa C,Di Rocco G,Trulli F,Paciaroni A,Battaglia S,Redler A,Fierro G,Giacomelli L

    更新日期:2012-06-01 00:00:00

  • Nanoscale bubble delivered YCD-TK/Cx26 gene therapeutic system suppresses tumor growth by inducing necrosis of tumor tissues in mouse Xenograft bladder cancer models.

    abstract:OBJECTIVE:Bladder cancer is considered as the fifth most common cancer in the whole world. This study aimed to investigate the anti-tumor effects of Nanoscale bubbles delivered yeast cytosine deaminase thymidine kinase/connexin 26 (YCD-TK/Cx26) on tumor cell proliferation and tumor growth. MATERIALS AND METHODS:Nanosc...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201909_18839

    authors: Fu YR,Luo Y,Xie X,Lu W,Zhang R,Xiong B,Chen F

    更新日期:2019-09-01 00:00:00

  • Induction of esophageal cancers by nitenpyram (NIT) in rats.

    abstract:OBJECTIVE:This study was made to investigate and evaluate the safety and carcinogenicity of nitenpyram (NIT) in rats. MATERIALS AND METHODS:A totally 50 male and 50 female SD rats were treated with NIT at 0, 800, 2400, and 7200 ppm, respectively, for 104 w. The growth, clinical signs, and survival rates, as well as th...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201812_16635

    authors: Xing LG,Wu YL,Zheng HN,Jia YY,Wu GF,Yang C

    更新日期:2018-12-01 00:00:00

  • Correlations between blood uric acid and the incidence and progression of type 2 diabetes nephropathy.

    abstract:OBJECTIVE:To investigate the relationships between blood uric acid (BUA) level and the incidence, progression and deterioration of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS:A total of fifty patients with T2DM alone whose glycosylated hemoglobin (HbA1c) were under ...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201801_14202

    authors: Li GX,Jiao XH,Cheng XB

    更新日期:2018-01-01 00:00:00

  • Predictors of survival in idiopathic interstitial pneumonia.

    abstract:AIM:To evaluate the ability of newly identified clinical factors to predict prognosis and survival in idiopathic pulmonary fibrosis (IPF) and non-specific interstitial pneumonia (NSIP). METHODS:Seventy-eight patients referred to the University of Genoa and the Regional Hospital of Aosta between January 1995 and Decemb...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Carbone R,Bottino G,Paredi P,Shah P,Meyer KC

    更新日期:2010-08-01 00:00:00

  • Well-known but rare pathogen in neonates: Listeria monocytogenes.

    abstract::Listeria monocytogenes is a very important life-threatening bacteria in certain risk groups such as neonates, pregnant women, elderly people, transplant recipients and others with impaired cell-mediated immunity. However, its infections are very rare in healthy children. Reports of listeriosis in newborn period are li...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Cekmez F,Tayman C,Saglam C,Cetinkaya M,Bedir O,Gnal A,Tun T,Sarici SÜ

    更新日期:2012-10-01 00:00:00

  • MiRNA-411 attenuates inflammatory damage and apoptosis following spinal cord injury.

    abstract:OBJECTIVE:To investigate the role and regulate the target of miRNA-411 on spinal cord injury. MATERIALS AND METHODS:The microglia cultured in vitro was activated by lipopolysaccharide (LPS) to express the inflammatory phenotype. The inflammatory response through miRNA-411 transfection in microglia was measured to cert...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202001_20022

    authors: Sun F,Li SG,Zhang HW,Hua FW,Sun GZ,Huang Z

    更新日期:2020-01-01 00:00:00

  • The mechanism and inhibitory effect of recombinant human P53 adenovirus injection combined with paclitaxel on human cervical cancer cell HeLa.

    abstract:OBJECTIVE:To investigate the effect of recombinant human p53 adenovirus injection combined with paclitaxel on human cervical cancer HeLa cell proliferation, apoptosis and expression of vascular endothelial growth factor (VEGF). MATERIALS AND METHODS:Detection of effects of paclitaxel, rAd-p53, and drug combination on ...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Liu YG,Zheng XL,Liu FM

    更新日期:2015-01-01 00:00:00

  • Diagnostic value of LncRNA-MEG3 as a serum biomarker in patients with hepatitis B complicated with liver fibrosis.

    abstract:OBJECTIVE:The aim of this work was to explore whether lncRNA-MEG3 could serve as a serum biomarker for diagnosing chronic hepatitis B (CHB) and improve the early diagnostic and treatment efficacies. PATIENTS AND METHODS:Serum level of lncRNA-MEG3 in CHB patients and healthy controls was detected by quantitative Real T...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201905_17943

    authors: Chen MJ,Wang XG,Sun ZX,Liu XC

    更新日期:2019-05-01 00:00:00

  • Long noncoding RNA LINC00858 promotes the proliferation, migration and invasion of gastric cancer cells via the miR-363-3p/FOXP4 axis.

    abstract:OBJECTIVE:Long non-coding RNA (lncRNA) LINC00858 has been found to exert oncogenic activity in several types of cancers, except gastric cancer (GC). In the present study, we aimed to explore the potential role of LINC00858 in GC and the underlying molecular mechanism. PATIENTS AND METHODS:The expression patterns of LI...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202009_23022

    authors: Ma HF,He WW,Wang JJ

    更新日期:2020-09-01 00:00:00

  • Circ-0003998 promotes cell proliferative ability and invasiveness by binding to miR-197-3p in osteosarcoma.

    abstract:OBJECTIVE:The aim of this study was to investigate the level of circ-0003998 in osteosarcoma tissues and cell lines, and to analyze its relation with prognosis of patients, as well as its effect on biological behaviors of osteosarcoma cells. In addition, the potential mechanism of circ-0003998 in promoting osteosarcoma...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201912_19761

    authors: Wang L,Du ZG,Huang H,Li FS,Li GS,Xu SN

    更新日期:2019-12-01 00:00:00

  • COVID-19 with bronchogram - a potential indication of prolonged treatment.

    abstract::Novel coronavirus disease-19 (COVID-19) has widely spread all over the world and seriously threatened people's health. This disease is currently diagnosed by clinical features, chest computed tomography (CT) scan, and nucleic acid test of severe acute respiratory syndrome coronavirus (SARS-CoV-2). Recently, some studi...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202006_21709

    authors: Qian WJ,Li L,Sun LY,Shi HR,Liu H,Jing X

    更新日期:2020-06-01 00:00:00

  • Phospholipases A-II (PLA2-II) induces acute pancreatitis through activation of the transcription factor NF-kappaB.

    abstract:OBJECTIVES:Acute pancreatitis (AP) is an inflammatory disease of the pancreas characterized by local inflammation. Secretory phospholipases A-II (sPLA2-II) have been implicated in triggering AP, but their exact role to evoke AP is largely unknown. NF-kB activation has previously been shown to induce acute pancreatitis....

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Zhang MS,Zhang KJ,Zhang J,Jiao XL,Chen D,Zhang DL

    更新日期:2014-01-01 00:00:00

  • Analysis of related factors of orolingual angioedema after rt-PA intravenous thrombolytic therapy.

    abstract:OBJECTIVE:Orolingual angioedema (OA) is a rare clinical complication with a potentially fatal risk that occurs after the intravenous application of alteplase (rt-PA) in patients with acute ischemic stroke. The purpose of this work is to investigate the related factors of OA in patients with acute ischemic stroke after ...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201803_14496

    authors: Wang YX,Li YQ,Chen Y,Zhang CH,Dong Z,Wang Z,Zhao SN,Li CH,Zhang PL

    更新日期:2018-03-01 00:00:00

  • Circ_0009910 promotes proliferation and metastasis of hepatocellular carcinoma cells through miR-335-5p/ROCK1 axis.

    abstract:OBJECTIVE:CircRNAs serve an essential role in regulating the development and progression of various tumors. The aim of this study was to examine the role and mechanism of circ_0009910 in hepatocellular carcinoma (HCC). MATERIALS AND METHODS:RT-qPCR was used to detect the expression of circ_0009910 and miR-335-5p in ti...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202002_20349

    authors: Li HW,Liu J

    更新日期:2020-02-01 00:00:00

  • Downregulation of lncRNA SNHG7 inhibits proliferation and invasion of nasopharyngeal carcinoma cells through repressing ROCK1.

    abstract::Since this article has been suspected of research misconduct and the corresponding authors did not respond to our request to prove originality of data and figures, "Downregulation of lncRNA SNHG7 inhibits proliferation and invasion of nasopharyngeal carcinoma cells through repressing ROCK1, by L. Wang, T. Xu, X. Cui, ...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202008_22451

    authors: Wang L,Xu T,Cui X,Han M,Zhou LH,Wei ZX,Xu ZJ,Jiang Y

    更新日期:2020-08-01 00:00:00

  • Pharmacokinetic of four probe drugs in adriamycin-induced nephropathy rat.

    abstract:BACKGROUND AND AIM:Probe drugs have been widely used to assess the activities of various CYP450 (cytochromes P450) isoenzymes in many fields of drug metabolism and pharmacogenetics. The nephrotic syndrome characterized by massive proteinuria and hypoproteinemia, whether that would influence the pharmacokinetics of prob...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Chen ZB,Zhi AY,Lin FY,Li D,Yu XG,Chen WH,Hu LF

    更新日期:2014-01-01 00:00:00

  • Probiotic administration of lactobacillus rhamnosus GR-1 attenuates atherosclerotic plaque formation in ApoE-/- mice fed with a high-fat diet.

    abstract:OBJECTIVE:To investigate the effect of Lactobacillus rhamnosus GR-1 on atherosclerotic progression in apolipoprotein-E knockout (ApoE-/-) mice fed with a high-fat diet and the underlying mechanisms of its action. MATERIALS AND METHODS:Eight-week-old ApoE-/- mice were treated with Lactobacillus rhamnosus GR-1 daily for...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_201904_17722

    authors: Fang Y,Chen HQ,Zhang X,Zhang H,Xia J,Ding K,Fang ZY

    更新日期:2019-04-01 00:00:00

  • N-acetylcysteine as powerful molecule to destroy bacterial biofilms. A systematic review.

    abstract:OBJECTIVE:Biofilms are microbial communities consisting of bacteria, extremely capable to self-reproduce on biological surfaces, causing infections. Frequently, these biofilms are resistant to classical antibacterial treatments and host immune response. Thus, new adjuvant molecules are mandatory in clinical practice. N...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章,评审

    doi:

    authors: Dinicola S,De Grazia S,Carlomagno G,Pintucci JP

    更新日期:2014-10-01 00:00:00

  • Long noncoding RNA UCA1 promotes proliferation and metastasis of thyroid cancer cells by sponging miR-497-3p.

    abstract::Since this article has been suspected of research misconduct and the corresponding authors did not respond to our request to prove originality of data and figures, "Long noncoding RNA UCA1 promotes proliferation and metastasis of thyroid cancer cells by sponging miR-497-3p, by H. Gao, J.-Y. Yang, L.-X. Tong, H. Jin, C...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:10.26355/eurrev_202007_22203

    authors: Gao H,Yang JY,Tong LX,Jin H,Liu CZ

    更新日期:2020-07-01 00:00:00

  • Effect of food restriction on reproductive-related genes and reproductive hormones in adult female rats.

    abstract:OBJECTIVES:A number of factors involved in the control of energy balance and metabolism act as modulators of gonadal axis. Ghrelin, a peptide secreted from the stomach and hypothalamus, has emerged as an orexigenic food intake controlling signal acting upon hypothalamus. Recently, the potential reproductive role of ghr...

    journal_title:European review for medical and pharmacological sciences

    pub_type: 杂志文章

    doi:

    authors: Ahmed HH,Khalil WK,Shousha WG,El-Sayed ES,Eskander EF,Selim RE

    更新日期:2012-11-01 00:00:00