Abstract：
BACKGROUND:In biology, it is easy to understand how a damaged functional system may generate wrong signals, but why this should happen when the system is disconnected is less clear. For this reason, among other pain syndromes, neuropathic pain (NP) following spinal cord injury (SCI) leaves most questions unanswered. AIMS AND METHODS:Our purpose is to review current knowledge on NP after SCI, focusing on the mechanisms, assessment and management of the syndrome. RESULTS:The mechanisms responsible for NP following SCI are poorly understood: NP is classically considered a "central pain syndrome" but recent evidence from experimental models reveals a possible "peripheral sensitization". Assessment of NP following SCI is well-established: in addition to clinical evaluation and self-reported scales, many neurophysiological, radiological and microscopic investigations may be performed. The management of NP following SCI is very difficult: evidence of effective drugs is lacking and alternative new treatment approaches yield different outcomes. CONCLUSIONS:Recently clinical and instrumental tools have increased our knowledge on NP, suggesting that the discovery of new treatment agents will depend on an explanation of what changes after SCI: future research must point in this direction.
journal_name
Eur Rev Med Pharmacol Scijournal_title
European review for medical and pharmacological sciencesauthors
D'Angelo R,Morreale A,Donadio V,Boriani S,Maraldi N,Plazzi G,Liguori Rsubject
Has Abstractpub_date
2013-12-01 00:00:00pages
3257-61issue
23eissn
1128-3602issn
2284-0729journal_volume
17pub_type
杂志文章,评审abstract：OBJECTIVE:The aim of this study was to explore the effects of micro ribonucleic acid (miR)-18a on the proliferation and apoptosis of gastric cancer (GC) cells, and to elucidate the possible underlying mechanism. PATIENTS AND METHODS:In this study, the expression of miR-18a in GC tissues and para-cancer tissues was ver...
journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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pub_type： 临床试验,杂志文章
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