Abstract:
BACKGROUND AND OBJECTIVES:It is increasingly recognized that a low grade of systemic inflammation occurs in patients with advanced chronic obstructive pulmonary disease (COPD). C-reactive protein (CRP), a marker of systemic chronic inflammatory response, has been related with decreased survival in large cohorts of COPD patients. The aim of the study was to assess if resting dynamic pulmonary hyperinflation (DH) is linked to the presence of systemic inflammation in COPD. MATERIALS AND METHODS:In a 12-month retrospective study involving 55 out-patients with COPD (FEV1 59+/- 23% pred.) examined in stable conditions, inspiratory capacity (IC) was measured at rest and considered as index of DH when lower than 80% predicted. Simultaneously, CRP (by immuno-turbidometry) and white blood cells (WBC), uric acid and alpha-1 globulins were measured in the venous blood in the morning before eating. RESULTS:CRP was significantly increased in the COPD patients with IC < 80% pred. (n = 35; IC = 61 + 14% pred.) as compared with that measured in COPD patients with IC > 80% pred. (n = 20; IC = 97 + 13% pred.), amounting to 0.70 +/- 0.59 vs 0.29 +/- 0.28 mg/dl, respectively (p < 0.01). CRP was inversely related to IC (% pred.) (r = 0.45, p < 0.01). WBC, serum uric acid (an endogenous danger signal), and albumin and alfa-1 globulins were not different between the two groups. DISCUSSION:These results show that the IC reduction is associated with higher serum levels of CRP in stable COPD patients, suggesting a potential role of dynamic pulmonary hyperinflation on development and maintenance of low grade systemic inflammation in COPD.
journal_name
Eur Rev Med Pharmacol Scijournal_title
European review for medical and pharmacological sciencesauthors
Gatta D,Aliprandi G,Pini L,Zanardini A,Fredi M,Tantucci Csubject
Has Abstractpub_date
2011-09-01 00:00:00pages
1068-73issue
9eissn
1128-3602issn
2284-0729journal_volume
15pub_type
杂志文章abstract:OBJECTIVE:We wished to evaluate the association between expression of microRNA (miR) -503 and prognosis in patients with cervical cancer. PATIENTS AND METHODS:96 paired specimens of cervical cancer and adjacent normal cervical epithelial tissues were obtained. qPCR was used to evaluate expression levels of miR-503. We...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
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更新日期:2015-11-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:10.26355/eurrev_202002_20198
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abstract::Coronary artery disease (CAD) represents the primary cause of death in Western Countries with an high incidence on human health and community social costs. Oxidative stress induced by reactive oxygen species (ROS) plays an important role in the aetiology of this disease. In particular, the LDL-oxidization has a key ro...
journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章,评审
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更新日期:2008-05-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章,评审
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
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更新日期:2010-11-01 00:00:00
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更新日期:2015-01-01 00:00:00
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更新日期:2010-05-01 00:00:00
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更新日期:2015-01-01 00:00:00
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更新日期:2017-04-01 00:00:00
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更新日期:2016-04-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
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更新日期:2014-01-01 00:00:00
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更新日期:2015-10-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
pub_type: 杂志文章
doi:
更新日期:2011-11-01 00:00:00
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doi:
更新日期:2013-08-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2015-12-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2020-10-01 00:00:00
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journal_title:European review for medical and pharmacological sciences
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doi:
更新日期:2004-09-01 00:00:00
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更新日期:2018-11-01 00:00:00
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更新日期:2014-01-01 00:00:00
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更新日期:2019-07-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2017-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00