当前位置： SCI文献检索 > European Review for Medical and Pharmacological Sciences期刊下所有文献 > Effect of miR-7 on resistance of breast cancer cells to adriamycin via regulating EGFR/PI3K signaling pathway.

Effect of miR-7 on resistance of breast cancer cells to adriamycin via regulating EGFR/PI3K signaling pathway.

Abstract：

OBJECTIVE:To explore whether micro ribonucleic acid (miR)-7 affects the resistance of breast cancer cells to adriamycin (ADR) through regulating the epidermal growth factor receptor (EGFR)/phosphatidylinositol 3-hydroxy kinase (PI3K) signaling pathway. MATERIALS AND METHODS:MiR-7 expression was compared among MCF-10A, MCF-7 and MCF-7/ADR cells. The MCF-7/ADR cells were divided into three groups, namely miR-7 control group (MCF-7/ADR drug-resistant strains), miR-7 inhibition group (miR-7-inhibited MCF-7/ADR drug-resistant strains) and miR-7 promotion group (MCF-7/ADR drug-resistant strains transfected with miR-7), and the messenger RNA (mRNA) and protein expression levels of MCF-7/ADR were evaluated via Western blotting. RESULTS:The expression level of miR-7 was substantially decreased in MCF-7 and MCF-7/ADR cells (p<0.05), and it was lowered more obviously in MCF-7/ADR cells than that in MCF-7 cells (p<0.05). Compared with that in miR-7 control group, miR-7 expression in miR-7 promotion group was notably raised (p<0.05), proving that the sensitivity of MCF-7/ADR cells to ADR was enhanced, while that in miR-7 inhibition group was significantly lowered (p<0.05). Compared with those in miR-7 control group, the mRNA and protein expression levels of EGFR and PI3K were elevated in miR-7 inhibition group (p<0.05), while they were lowered in miR-7 promotion group (p<0.05). Additionally, compared with those in miR-7 control group, the proliferation and apoptosis abilities of cells in miR-7 inhibition group were markedly enhanced (p<0.05) and weakened (p<0.05), respectively, while they were weakened (p<0.05) and significantly strengthened (p<0.05), respectively in miR-7 inhibition group. CONCLUSIONS:MiR-7 plays an important role in the resistance of breast cancer cells to ADR, and its over-expression can inhibit the EGFR/PI3K signaling pathway to raise their sensitivity to the chemotherapy drug ADR.

journal_name

Eur Rev Med Pharmacol Sci

journal_title

European review for medical and pharmacological sciences

authors

Huang Q,Wu YY,Xing SJ,Yu ZW

doi

10.26355/eurrev_201906_18195

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

5285-5292

issue

12

eissn

1128-3602

issn

2284-0729

journal_volume

23

pub_type

杂志文章

相关文献

European Review for Medical and Pharmacological Sciences文献大全
  • Clinical features, imaging findings, treatment aspects of elastofibroma dorsi and long-term outcomes after surgical resection.

    abstract：OBJECTIVE:We aim to present clinical features, imaging findings, treatment aspects of the elastofibroma dorsi (ED), which is a benign tumor arising from connective tissue at the scapular region, and long-term outcomes after surgical resection. PATIENTS AND METHODS:We evaluated retrospectively 82 patients (55 females, ...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Bartocci M,Dell'Atti C,Meacci E,Congedo MT,Magarelli N,Bonomo L,Leone A

    更新日期：2017-05-01 00:00:00

  • Neurotoxic effect of statins on mouse neuroblastoma NB2a cell line.

    abstract：OBJECTIVE:Evidences from cell culture experiments suggest a link between cholesterol and nervous system disease. Statins may have neurotoxic or neuroprotective effects, but these effects remain controversial. Therefore, the present study was aimed to investigate the possible toxicity of statins on a neurite outgrowth i...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Vural K,Tuğlu MI

    更新日期：2011-09-01 00:00:00

  • Radiofrequency Y-V anoplasty in the treatment of anal stenosis.

    abstract：BACKGROUND:Anal stenosis is a common proctologic disease often caused from hemorrhoids surgery. Treatments adopted are many and varied. In this study we applied radiofrequencies to the classic Y-V anoplasty operation and reported results obtained. METHODS:Eligibility criteria consisted of patients affected by anal ste...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Filingeri V,Gravante G,Cassisa D

    更新日期：2006-09-01 00:00:00

  • Circular RNA circDENND4C facilitates proliferation, migration and glycolysis of colorectal cancer cells through miR-760/GLUT1 axis.

    abstract：OBJECTIVE:Colorectal cancer is a common malignant tumor of the digestive tract, and its incidence is closely related to lifestyle inheritance and colorectal adenoma. Circular RNA (circRNA) has been proved to participate in the progression of colorectal cancer cells. Our study aimed to investigate the function and the u...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_202003_20506

    authors： Zhang ZJ,Zhang YH,Qin XJ,Wang YX,Fu J

    更新日期：2020-03-01 00:00:00

  • MiR-146a regulates the development of ulcerative colitis via mediating the TLR4/MyD88/NF-κB signaling pathway.

    abstract：OBJECTIVE:To study the effect of micro ribonucleic acid (miR)-146a on the development of ulcerative colitis (UC) and to explore its regulatory effect on the Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88) and nuclear factor-kappa B (NF-κB) signaling pathways. MATERIALS AND METHODS:The UC model in...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201903_17260

    authors： Wang JP,Dong LN,Wang M,Guo J,Zhao YQ

    更新日期：2019-03-01 00:00:00

  • Effects of oleic acid on SP-B expression and release in A549 cells.

    abstract：OBJECTIVE:Pulmonary surfactant-associated protein B (SP-B), which is synthesized and secreted by alveolar epithelial type II cells, is crucial for normal functioning of pulmonary surfactant. Degeneration of pulmonary surfactant is the essential cause of acute lung injury (ALI). ALI is often studied in animal models usi...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Zhou DJ,Chen Y,Zhang XJ,Ma C,Qiu J,Zhou JH

    更新日期：2015-09-01 00:00:00

  • MiR-655-3p inhibits growth and invasiveness of trophoblasts via targeting PBX3 and thus deteriorates preeclampsia.

    abstract：OBJECTIVE:The purpose of this study was to elucidate the regulatory effects of microRNA-655-3p (miR-655-3p) on growth and invasiveness of trophoblasts to influence the development of preeclampsia (PE). PATIENTS AND METHODS:Relative levels of miR-655-3p and PBX3 in 24 PE pregnant women and 24 healthy ones were examined...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_202010_23383

    authors： Song H,Wang X,Li JC,Lv YH

    更新日期：2020-10-01 00:00:00

  • MicroRNA-126 affects cell apoptosis, proliferation, cell cycle and modulates VEGF/TGF-β levels in pulmonary artery endothelial cells.

    abstract：OBJECTIVE:In the clinic, therapeutic options for pulmonary arterial hypertension are limited; therefore, investigating the therapeutic strategies and novel therapies is critical for pulmonary arterial hypertension (PAH) treatment. This study aimed to evaluate the role of miRNA-126 (miR-126) and its associated signaling...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201904_17588

    authors： Yuan Y,Shen C,Zhao SL,Hu YJ,Song Y,Zhong QJ

    更新日期：2019-04-01 00:00:00

  • Effect of ulinastatin on myocardial ischemia-reperfusion injury through JNK and P38 MAPK signaling pathways.

    abstract：OBJECTIVE:The aim of this study was to investigate the effect of ulinastatin (UTI) on myocardial ischemia-reperfusion injury (MIRI) through the c-Jun N-terminal kinase (JNK) signaling pathway and p38 mitogen-activated protein kinase (MAPK) signaling pathway. MATERIALS AND METHODS:Healthy adult male Sprague-Dawley (SD)...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201910_19183

    authors： Yang ZH,Lu YJ,Gu KP,Xiang ZY,Huang HM

    更新日期：2019-10-01 00:00:00

  • Differential response of cardiac aquaporins to hyperosmotic stress; salutary role of AQP1 against the induced apoptosis.

    abstract：OBJECTIVE:Multiple pathophysiological conditions are associated with disturbance of myocardial osmotic equilibrium, exerting detrimental effects on cardiac performance. Cardiac myocytes may encounter hyperosmotic stress during hyperglycemia, ischemia/reperfusion injury, myocardial infarction, diabetes mellitus, severe ...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_202101_24397

    authors： Aggeli IK,Kapogiannatou A,Paraskevopoulou F,Gaitanaki C

    更新日期：2021-01-01 00:00:00

  • The effect of DC+CIK combined therapy on rat liver cancer model and its modulatory effect on immune functions.

    abstract：OBJECTIVE:Primary liver cancer is a sort of the most common solid tumors occurred in the digestive system. The incidence and mortality rate maintain at a high level, thus leading to heavy economic and psychological burdens for patients. Next-generation biological therapy, such as cellular immune treatment, improves the...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201802_14312

    authors： He W,Huang Z,Zhou S,Huang L,Wang B,Zhu L,Ding Y,Yu YL,Zhang S

    更新日期：2018-02-01 00:00:00

  • MiR-21 relieves rheumatoid arthritis in rats via targeting Wnt signaling pathway.

    abstract：OBJECTIVE:To investigate the influence of micro ribonucleic acid (miR)-21 on rats with rheumatoid arthritis (RA) through the Wnt signaling pathway. MATERIALS AND METHODS:A total of 30 rats were divided into three groups: control group (healthy rats, n=10), model group (rat model of RA, n=10), and MiR group (rat model ...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201908_18635

    authors： Liu XG,Zhang Y,Ju WF,Li CY,Mu YC

    更新日期：2019-08-01 00:00:00

  • Bilberry extracts are not created equal: the role of non anthocyanin fraction. Discovering the "dark side of the force" in a preliminary study.

    abstract：OBJECTIVE:Several experimental studies and clinical trials support the potential of bilberry (Vaccinium myrtillus L) extracts in promoting eye health and circulation. Many active ingredients have been isolated from the berries and leaves of the bilberry plant. However, anthocyanins represent the most widely studied bio...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Gizzi C,Belcaro G,Gizzi G,Feragalli B,Dugall M,Luzzi R,Cornelli U

    更新日期：2016-06-01 00:00:00

  • BNIP1 inhibits cell proliferation, migration and invasion, and promotes apoptosis by mTOR in cervical cancer cells.

    abstract：OBJECTIVE:BNIP1, a member of the BH3-only protein family, plays essential roles in a variety of biological processes. However, the mechanism and function of BNIP1 are still unknown in cervical cancer. We aim to explore the roles of BNIP1 on cervical cancer cell proliferation, apoptosis, migration, and invasion abilitie...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201902_17096

    authors： Li FH,Xiang L,Ran L,Zhou S,Huang Z,Chen M,Yu WF

    更新日期：2019-02-01 00:00:00

  • Knockdown of long noncoding RNA linc-ITGB1 suppresses migration, invasion of hepatocellular carcinoma via regulating ZEB1.

    abstract：OBJECTIVE:This research focuses on the influence of linc-ITGB1 on the metastasis of hepatocellular carcinoma and further explores its underlying mechanism. PATIENTS AND METHODS:A total of 70 hepatocellular carcinoma patients were chosen for our study. RT-qPCR was used for detecting the expression level of linc-ITGB1 i...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201711_13823

    authors： Yu WW,Wang K,Liao GJ

    更新日期：2017-11-01 00:00:00

  • N-acetylcysteine as powerful molecule to destroy bacterial biofilms. A systematic review.

    abstract：OBJECTIVE:Biofilms are microbial communities consisting of bacteria, extremely capable to self-reproduce on biological surfaces, causing infections. Frequently, these biofilms are resistant to classical antibacterial treatments and host immune response. Thus, new adjuvant molecules are mandatory in clinical practice. N...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章,评审

    doi：

    authors： Dinicola S,De Grazia S,Carlomagno G,Pintucci JP

    更新日期：2014-10-01 00:00:00

  • The ultra early diagnosis of Parkinson's disease by the enhanced substantia nigra echo.

    abstract：OBJECTIVE:Our objective is to determine the value of enhanced substantia nigra echo in the diagnosis of Parkinson's disease by analyzing the intensity and area of substantia nigra echo by transcranial Doppler sonography (TCS). PATIENTS AND METHODS:36 patients diagnosed as ultra early stage Parkinson's disease between ...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Zhuang JJ,Zheng YH,Xu XW,Zhou L

    更新日期：2015-12-01 00:00:00

  • CircRNA_0016418 expedites the progression of human skin melanoma via miR-625/YY1 axis.

    abstract：OBJECTIVE:Some circular RNAs (circRNAs) have been testified to play crucial roles in the regulation of skin melanoma, including circRNA_0016418 (circ0016418). However, the regulatory mechanism of circ0016418 in skin melanoma is undiscovered. MATERIALS AND METHODS:The RNA expression was examined through quantitative Re...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201912_19795

    authors： Zou Y,Wang SS,Wang J,Su HL,Xu JH

    更新日期：2019-12-01 00:00:00

  • The role of endothelial nitric oxide synthase (eNOS) in the pathogenesis of sinonasal polyps.

    abstract：OBJECTIVE:The pathogenesis of sinonasal polyps has not been known completely. We investigated the role of endothelial Nitric Oxide Synthase (eNOS) in the pathogenesis of sinonasal polyps. PATIENTS AND METHODS:Study group (Groups 1-3) consisted of nasal polyp samples of patients with sinonasal polyps; and control group...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Muluk NB,Arikan OK,Atasoy P,Kiliç R,Yalçinozan ET

    更新日期：2014-01-01 00:00:00

  • Long-term survival of a patient with acute neonatal-onset metabolic encephalopathy with carbamoyl phosphate synthetase 1 deficiency.

    abstract：OBJECTIVE:Long-term survival of patients with neonatal-onset carbamoyl-phosphate synthetase 1 deficiency (CPS1D), an autosomal recessive disorder characterized by repeated, life-threatening hyperammonemia, is rare. We describe the diagnosis and clinical management of a teenager with neonatal-onset CPS1D who did not und...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_202010_23220

    authors： Imataka G,Ishii J,Ando Y,Yoshihara S,Takagi Y,Nitta A,Arisaka O,Yoshihara S

    更新日期：2020-10-01 00:00:00

  • The effect of low dosage of procaine on lung cancer cell proliferation.

    abstract：OBJECTIVE:Non-small cell lung cancer (NSCLC) is the most common type of human lung cancer leading cause of cancer death worldwide. However, first-line drugs such as gefitinib and erlotinib showed great drug resistance in the clinical. MATERIALS AND METHODS:The cell proliferation was evaluated by MTT assay; gene expres...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Ma XW,Li Y,Han XC,Xin QZ

    更新日期：2016-11-01 00:00:00

  • Influence of miR-34a on cerebral neuronal apoptosis in rats with cerebral ischemia reperfusion through the Notch1 signaling pathway.

    abstract：OBJECTIVE:To explore the influence and the underlying mechanism of micro-ribonucleic acid (miR)-34a on cerebral neuronal apoptosis in rats with cerebral ischemia-reperfusion (CIR). MATERIALS AND METHODS:60 adult male Wistar rats were randomly divided into 3 groups: Sham group, CIR group and miR-34a knockdown group. Th...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201909_19021

    authors： Wang SP,Wang D,Li HX,Liu L,Duan XH

    更新日期：2019-09-01 00:00:00

  • Phospholipases A-II (PLA2-II) induces acute pancreatitis through activation of the transcription factor NF-kappaB.

    abstract：OBJECTIVES:Acute pancreatitis (AP) is an inflammatory disease of the pancreas characterized by local inflammation. Secretory phospholipases A-II (sPLA2-II) have been implicated in triggering AP, but their exact role to evoke AP is largely unknown. NF-kB activation has previously been shown to induce acute pancreatitis....

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Zhang MS,Zhang KJ,Zhang J,Jiao XL,Chen D,Zhang DL

    更新日期：2014-01-01 00:00:00

  • Role of nicotinic acetylcholine receptor subtypes on nicotine's enhancing effect on electrical field stimulation elicited contractile responses in rabbit urine bladder.

    abstract：OBJECTIVE:This study aims to investigate the contribution of presynaptic nicotinic acetylcholine receptors (nAChRs) sub-types to nicotine-induced enhancement in electrical field stimulation (EFS) EFS-mediated contractile responses in rabbit urine bladder smooth muscle preparations. MATERIALS AND METHODS:Rabbit urine b...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Ozturk Fincan GS,Vural IM,Yildirim SS,Isli F,Dilekoz E,Ercan S,Sarioglu Y

    更新日期：2016-04-01 00:00:00

  • The expression of TRPM7 in serum of patients with sepsis, its influences on inflammatory factors and prognosis, and its diagnostic value.

    abstract：OBJECTIVE:This study aimed to investigate the expression of TRPM7 in the serum of patients with sepsis and its influences on inflammatory factors and prognosis. PATIENTS AND METHODS:A prospective analysis was performed. 78 patients with sepsis were enrolled in the experimental group and treated from May 2015 to April ...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201905_17821

    authors： Liu H,Wang SY,Li XD,Yang S,Liu XY,Yang CW,Liu YF

    更新日期：2019-05-01 00:00:00

  • Gastrointestinal tract duplications in children.

    abstract：AIM:Gastrointestinal tract duplications (GTD) are rare congenital abnormalities that can occur anywhere along the gastrointestinal tract. These anomalies may present as a single, multiple, or a vague pathologies. Diagnosing and treating these diseases may be difficult in some patients. We aimed to present 32 patients w...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Okur MH,Arslan MS,Arslan S,Aydogdu B,Türkçü G,Goya C,Uygun I,Cigdem MK,Önen A,Otcu S

    更新日期：2014-01-01 00:00:00

  • Correlation between miR-1207-5p expression with steroid-induced necrosis of femoral head and VEGF expression.

    abstract：OBJECTIVE:The aim of this study was to investigate the expression level of micro-ribonucleic acid-1207-5p (miR-1207-5p) in steroid-induced necrosis of femoral head (SNFH) and its correlation with SNFH. Meanwhile, we also aimed to analyze the relationship between miR-1207-5p expression and vascular endothelial growth fa...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201904_17541

    authors： Chao PC,Cui MY,Li XA,Jiang Y,Lin BC,Li ZB

    更新日期：2019-04-01 00:00:00

  • PFNA vs. DHS helical blade for elderly patients with osteoporotic femoral intertrochanteric fractures.

    abstract：OBJECTIVE:This study sought to compare the effects of proximal femoral nail anti-rotation (PFNA) and dynamic hip screw (DHS) helical blade treatments in patients with osteoporotic femoral intertrochanteric fractures. PATIENTS AND METHODS:Eighty elderly osteoporosis patients with femoral intertrochanteric fracture comp...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201807_15346

    authors： Li H,Wang Q,Dai GG,Peng H

    更新日期：2018-07-01 00:00:00

  • MiRNA-138-5p protects the early diabetic retinopathy by regulating NOVA1.

    abstract：OBJECTIVE:To elucidate the function of miRNA-138-5p in the early diabetic retinopathy (DR) and the potential mechanism. MATERIALS AND METHODS:DR model in rats was first established by streptozotocin (STZ) injection. MiRNA-138-5p expression in rat retinal tissues was determined by quantitative Real Time-Polymerase Chai...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：10.26355/eurrev_201909_18984

    authors： Bao XY,Cao J

    更新日期：2019-09-01 00:00:00

  • Piscicidal activity of leaf and bark extract of Thevetia peruviana plant and their biochemical stress response on fish metabolism.

    abstract：OBJECTIVES:The leaf and bark of Thevetia peruviana (Family: Apocynaceae) plant was administered for 24 h to the freshwater fish Catla catla (Hamilton) to evaluate their piscicidal activity in laboratory and cemented pond condition. MATERIALS AND METHODS AND RESULTS:The LC0 values of lef and bark extracts of different ...

    journal_title：European review for medical and pharmacological sciences

    pub_type： 杂志文章

    doi：

    authors： Singh SK,Yadav RP,Singh A

    更新日期：2010-11-01 00:00:00