APOLIPOPROTEINS AND THEIR ASSOCIATION WITH CARDIOMETABOLIC RISK BIOMARKERS IN ADOLESCENTS.

Abstract:

INTRODUCTION:the apoB/apo A-I ratio has been reported as an important predictor of cardiovascular risk, being superior to lipids, lipoproteins and conventional lipid ratios. OBJECTIVE:to investigate the association between apolipoproteins A-I and B, and the apolipoprotein B/apolipoprotein A-I ratio and cardiometabolic risk variables in adolescents. METHODS:this was a cross-sectional study including 104 adolescents of public schools in Recife during the months of March/April, 2013. Sociodemographic, anthropometric, clinical and biochemical variables were analysed. The apolipoproteins were analysed via Immunoturbidimetry. RESULTS:body mass index, waist circumference, waist circumference/height, triglycerides, cholesterol/HDL, and apolipoprotein B/apolipoprotein A-I declined with the progress of the percentile distribution of apolipoprotein A-I concentrations, while the HDL and apolipoprotein B increased between the first and last quartiles of the apolipoprotein A-I concentrations. Systolic blood pressure, body mass index, waist circumference, waist circumference/height, cholesterol, LDL, triglycerides, cholesterol/HDL, and LDL/HDL increased progressively in the quartile distribution of the concentrations of apolipoprotein B and apolipoprotein B/apolipoprotein A-I. Alfa-1-acid glycoprotein serum levels increased hand-inhand with the percentile progression of apolipoprotein B. CONCLUSIONS:the findings underline an important association of apolipoproteins A-I and B, and the apolipoprotein B/apolipoprotein A-I ratio and their clinical, biochemical and anthropometric cardiometabolic risk. However, prospective studies are important to evaluate the pertinence of implementing these markers in the clinical practice. :Introducción: la razón apo B/apo A-I sigue siendo reportada como un predictor importante de riesgo cardiovascular, superior a lípidos, lipoproteínas y razones lipídicas convencionales. Objetivo: investigar la asociación entre las apolipoproteínas A-I y B y la razón apolipoproteína B/apolipoproteína A-I con variables de riesgo cardiometabólico en adolescentes. Métodos: estudio de corte transversal que incluye a 104 adolescentes de escuelas públicas de Recife, entre marzo/abril de 2013. Se evaluaron variables clínicas, bioquímicas, antropométricas y sociodemográficas. Se analizaron las apolipoproteínas por imunoturbidimetría. Resultados: índice de masa corporal, circunferencia de la cintura, circunferencia de la cintura/altura, triglicéridos, colesterol/HDL y apolipoproteína B/apolipoproteína A-I mostraron una reducción con la progresión de la distribución en percentil de las concentraciones de apolipoproteína A-I, mientras que HDL y apolipoproteína B aumentaron entre el primero y el último cuartil de las concentraciones de apolipoproteína A-I. Tensión arterial sistólica, índice de masa corporal, circunferencia de la cintura, circunferencia de la cintura/altura, colesterol, LDL, triglicéridos, colesterol/HDL y LDL/HDL presentaron un aumento progresivo en la distribución en cuartiles de las concentraciones de apolipoproteína B y de la apolipoproteína B/apolipoproteína A-I. Los niveles séricos de alfa-1-glicoproteína ácida aumentaron paralelamente a la progresión en percentil de apolipoproteína B. Conclusiones: los hallazgos evidencian una asociación importante de las apolipoproteínas A-I y B y de la razón apolipoproteína B/apolipoproteína A-I con biomarcadores clínicos, bioquímicos y antropométricos de riesgo cardiometabólico. Sin embargo, son recomendables estudios prospectivos para evaluar la pertenencia de la implementación de esos marcadores en la práctica clínica.

journal_name

Nutr Hosp

journal_title

Nutricion hospitalaria

authors

Neyla de Lima Albuquerque M,da Silva Diniz A,Kruze Grande de Arruda I

doi

10.3305/nh.2015.32.6.9779

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

2674-83

issue

6

eissn

0212-1611

issn

1699-5198

journal_volume

32

pub_type

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