The microbiota, a necessary element of immunity.

Abstract:

:The intestinal microbiota is essential for digestion, the production of physiological metabolites, and defense. More than 1013 bacteria are present in the intestine, inspiring awe as well as fear of potential infections. By definition, the immune system protects us from infection, and is given the task to recognize dangerous pathogens from useful mutualists. Nevertheless, the definition of pathogens and mutualists is often contextual, and the immune system reacts to all types of microbes. In fact, immune reactivity to microbiota is necessary for the development of the immune system. If the host-microbe cross-talk is perturbed before birth or weaning, the immune system develops "pathological imprinting" and increased susceptibility to inflammatory pathology later in life. Reactivity to microbiota is also important in adulthood to regulate immune responses and maintain homeostasis.

journal_name

C R Biol

journal_title

Comptes rendus biologies

authors

Eberl G

doi

10.1016/j.crvi.2018.03.003

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

281-283

issue

5

eissn

1631-0691

issn

1768-3238

pii

S1631-0691(18)30048-9

journal_volume

341

pub_type

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