The melanocortins and melanin-concentrating hormone in the central regulation of feeding behavior and energy homeostasis.

Abstract:

:A number of different neuropeptides exert powerful concerted controls on feeding behavior and energy balance, most of them being produced in hypothalamic neuronal networks under stimulation by anabolic and catabolic peripheral hormones such as ghrelin and leptin, respectively. These peptide-expressing neurons interconnect extensively to integrate the multiple opposing signals that mediate changes in energy expenditure. In the present review I have summarized our current knowledge about two key peptidic systems involved in regulating appetite and energy homeostasis, the melanocortin system (alpha-MSH, agouti and Agouti-related peptides, MC receptors and mahogany protein) and the melanin-concentrating hormone system (proMCH-derived peptides and MCH receptors) that contribute to satiety and feeding-initiation, respectively, with concurrent effects on energy expenditure. I have focused particularly on recent data concerning transgenic mice and the ongoing development of MC/MCH receptor antagonists/agonists that may represent promising drugs to treat human eating disorders on both sides of the energy balance (anorexia, obesity).

journal_name

C R Biol

journal_title

Comptes rendus biologies

authors

Nahon JL

doi

10.1016/j.crvi.2006.03.021

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

623-38; discussion 653-5

issue

8

eissn

1631-0691

issn

1768-3238

pii

S1631-0691(06)00086-2

journal_volume

329

pub_type

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