Abstract:
:A number of different neuropeptides exert powerful concerted controls on feeding behavior and energy balance, most of them being produced in hypothalamic neuronal networks under stimulation by anabolic and catabolic peripheral hormones such as ghrelin and leptin, respectively. These peptide-expressing neurons interconnect extensively to integrate the multiple opposing signals that mediate changes in energy expenditure. In the present review I have summarized our current knowledge about two key peptidic systems involved in regulating appetite and energy homeostasis, the melanocortin system (alpha-MSH, agouti and Agouti-related peptides, MC receptors and mahogany protein) and the melanin-concentrating hormone system (proMCH-derived peptides and MCH receptors) that contribute to satiety and feeding-initiation, respectively, with concurrent effects on energy expenditure. I have focused particularly on recent data concerning transgenic mice and the ongoing development of MC/MCH receptor antagonists/agonists that may represent promising drugs to treat human eating disorders on both sides of the energy balance (anorexia, obesity).
journal_name
C R Bioljournal_title
Comptes rendus biologiesauthors
Nahon JLdoi
10.1016/j.crvi.2006.03.021subject
Has Abstractpub_date
2006-08-01 00:00:00pages
623-38; discussion 653-5issue
8eissn
1631-0691issn
1768-3238pii
S1631-0691(06)00086-2journal_volume
329pub_type
杂志文章,评审abstract::Two aspects of psychology and physiology of time are dealt with in this paper: the way time perception was increasingly studied during the 19th century by scientists, including many physicists, and the way the temporal properties of the nervous system were discovered and explored by physiologists. The neurophysiologic...
journal_title:Comptes rendus biologies
pub_type: 历史文章,杂志文章
doi:10.1016/j.crvi.2006.03.004
更新日期:2006-05-01 00:00:00
abstract::Phylogeny, be it morphological or molecular, has long tried to explain the extant biodiversity by the Tree of Species, which is a logical consequence of strict Darwinian evolutionary principles. Through constant improvement of both methods and data sets, some parts of this diversity have actually been demonstrated to ...
journal_title:Comptes rendus biologies
pub_type: 杂志文章,评审
doi:10.1016/j.crvi.2008.07.003
更新日期:2009-02-01 00:00:00
abstract::Studies on the cognitive abilities of manatees are limited despite their importance for the environmental enrichment and welfare of individuals in captivity and the understanding of manatee behaviour in the wild. Our study analyses how the presence of new stimuli and their association with food may have changed the be...
journal_title:Comptes rendus biologies
pub_type: 新闻
doi:10.5802/crbiol.6
更新日期:2020-06-05 00:00:00
abstract::Despite the fact that coverage is one of the most widely used descriptors for seagrass meadows, the spatial structure of coverage at mesoscale has not often been taken into account. The present work investigates the structure of P. oceanica coverage at mesoscale and its possible relationship with several factors (dept...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2006.05.001
更新日期:2006-09-01 00:00:00
abstract::In the present investigation, a total of 51 marine fungi were obtained from wood samples collected from four locations of Tamil Nadu (Tuthukudi, Chennai, Kanyakumari and Pichavaram), India. Out of these 51, 28 were ascomycetes, one was basidiomycete and 22 were mitosporic fungi. Maximum fungal diversity was encountere...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2008.03.008
更新日期:2008-06-01 00:00:00
abstract::Data on mineral elements in spirulinas being limited, we analyzed macrominerals and trace elements of samples from France and Africa. Spirulinas cultivated in France have a composition in macromineral elements similar to those of the literature. The entire contents of trace elements are low. Unlike marine cyanobacteri...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2013.11.004
更新日期:2014-01-01 00:00:00
abstract::This study aims at characterization four cultivars of the olive trees, Chétoui, Chemlali, Gerboui, and Chaïbi, cultivated in three different geographical locations, from pomological and technological points of view. The pomological characters of the fruit are influenced by the geographical location. Each individual of...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2006.11.005
更新日期:2007-02-01 00:00:00
abstract::This paper deals with the effects of agronomic practices on parasite life cycles, and the design of integrated crop protection strategies. Cropping systems have a large effect on the size of the primary inoculum and its localisation, on the development and spread of epidemics, and on the coordination of the life cycle...
journal_title:Comptes rendus biologies
pub_type: 杂志文章,评审
doi:10.1016/s1631-0691(03)00006-4
更新日期:2003-01-01 00:00:00
abstract::The role of the eyes, and more precisely that of the ommatidian pigments, in the control of daily rhythms of movement of Daphnia longispina is investigated. In the laboratory, under permanent light (LL), the pigmentary modifications observed are globally similar to those observed in situ, except in their timing, aroun...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2003.09.037
更新日期:2003-12-01 00:00:00
abstract::5-(Hydroxymethyl)uracil, 5-formyluracil or 5-carboxyuracil can be formed in DNA upon exposure to ionizing radiations. We report the effect of the latter oxidative lesions on the in vitro transcription by T7 RNA polymerase using a single-stranded short model template. Kinetic experiments showed that the transcription y...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2005.07.003
更新日期:2005-09-01 00:00:00
abstract::Two ground-dwelling couas species, Coquerel's Coua Coua coquereli and Giant Coua Coua gigas, live in sympatry in the dry forest of Madagascar. These birds are typically insectivorous and mainly feed at ground level. The two species differ by size but have the same morphology, suggesting they have the same physical att...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2009.01.005
更新日期:2009-06-01 00:00:00
abstract::An agent-based model (AMB) used to simulate the spread of Human African Trypanosomiasis is presented together with the results of simulations of a focus of the disease. This model is a completely spatialized approach taking into account a series of often overlooked parameters such as human behaviour (activity-related ...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2003.12.002
更新日期:2004-01-01 00:00:00
abstract::The paper provides a mathematical study of a model of urban dynamics, adjusting to an ecological model proposed by Lotka and Volterra. The model is a system of two first-order non-linear ordinary differential equations. The study proposed here completes the original proof by using the main tools such as a Lyapunov fun...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2004.09.006
更新日期:2004-11-01 00:00:00
abstract::We propose to start the analysis of complex systems by systematically identifying the feedback circuits that govern their dynamics. These circuits can be identified without any ambiguity by examining the Jacobian matrix of the system. They provide precious information regarding the number and nature of steady states. ...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/s1631-0691(02)01452-x
更新日期:2002-04-01 00:00:00
abstract::Aphids are among the few organisms capable of reproducing either sexually or asexually. This plasticity in reproductive mode is viewed as an adaptive response to cope with seasonal changes. Clonal reproduction occurs during the growing season allowing rapid population increase, while sexual reproduction occurs during ...
journal_title:Comptes rendus biologies
pub_type: 杂志文章,评审
doi:10.1016/j.crvi.2010.03.003
更新日期:2010-06-01 00:00:00
abstract::This paper suggests three additions to the Hildebrand method for gait-pattern specification. The first allows an extension of this method by the use of the forelimb as reference. Thus, dataset could be gathered indifferently from fore or hindlimbs cycles to identify a symmetrical gait or compare gaits of diverse speci...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2003.11.005
更新日期:2004-02-01 00:00:00
abstract::The spatial variation of soil pH and soil organic matter (SOM) in the urban area of Xuzhou, China, was investigated in this study. Conventional statistics, geostatistics, and a geographical information system (GIS) were used to produce spatial distribution maps and to provide information about land use types. A total ...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2014.02.008
更新日期:2014-05-01 00:00:00
abstract::The present study focuses on the potential of glucose oxidase (GOD) as a promising biocontrol agent for fungal plant pathogens. In fact, a new GOD producing fungus was isolated and identified as an Aspergillus tubingensis. GOD (125 AU) has been found to inhibit Fusarium solani growth and spore production. Indeed, GOD ...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2015.05.007
更新日期:2015-10-01 00:00:00
abstract::This study was undertaken to assess the risk of poisoning due to consumption of the puffer fish Lagocephalus lagocephalus collected along the Tunisian coast. Wistar rats were daily intraperitoneally injected, for 10 days, with acidic extracts of liver or flesh (muscles + skin) of L. lagocephalus. Control rats received...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2008.05.005
更新日期:2008-08-01 00:00:00
abstract::The polymorphism of the mitochondrial gene cytochrome oxidase III was studied in the Mediterranean octopus, Octopus vulgaris Cuvier, 1797. A total of 202 specimens from seven sampling sites were analysed with the aim of elucidating patterns of genetic structure in the central Mediterranean Sea and to give an insight i...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2012.10.004
更新日期:2012-10-01 00:00:00
abstract::13C- and deuterium (D)-labeled ferulic acid and sinapic acid ([8-(13)C, 3-OCD3]-ferulic acid and [8-(13)C, 3,5-OCD3]-sinapic acid) were administered to robinia (Robinia pseudoacacia L.) shoots. To estimate the distribution of the label from administrated ferulic or sinapic acid, continuous 50-microm-thick tangential s...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2004.07.012
更新日期:2004-09-01 00:00:00
abstract::The wild plant known as Calotropis procera is important in medicine, industry and ornamental fields. Due to spread in areas that suffer from environmental stress, it has a large number of tolerance genes to environmental stress such as drought and salinity. Proline is one of the most compatible solutes that accumulate...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2014.09.002
更新日期:2014-12-01 00:00:00
abstract::Females must evaluate male quality to perform mate choice. Since females generally base their selection on different male features, individual females may differ in their choice. In this study, we show that concordance between females in mate choice decisions may arise without any experimental maximization of a partic...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2012.01.004
更新日期:2012-03-01 00:00:00
abstract::Ancientness and maturity are two major qualities of forest ecosystems. They are components of naturalness and are affected by human impact. These qualities and the associated terms are often mixed up and incorrectly used. We have carried out a synthesis in order to propose an adapted French terminology based on intern...
journal_title:Comptes rendus biologies
pub_type: 杂志文章,评审
doi:10.1016/j.crvi.2014.10.004
更新日期:2015-01-01 00:00:00
abstract::For a very long time, arguments supporting the neuro-humoral theory, produced by the pharmacologist Henri Dale, did not convince one of the main supporters of the electrical theory, the neurophysiologist John C. Eccles. This article gives a reminder of certain technical elements of this debate between two giants, whic...
journal_title:Comptes rendus biologies
pub_type: 传,历史文章,杂志文章
doi:10.1016/j.crvi.2006.03.013
更新日期:2006-05-01 00:00:00
abstract::Several studies have demonstrated that, in a context of oxidative stress, resveratrol, a polyphenol found in wine, could act as a protective agent on endothelial cells by various mechanisms but without showing that it could penetrate inside the cell. The aim of this study was to detect for the first time resveratrol i...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2012.03.013
更新日期:2012-04-01 00:00:00
abstract::The aim of this work is to assess the use of (SPOT) multispectral visible infrared remote sensing to study microphytobentos assemblages in a shellfish ecosystem (Bay of Bourgneuf, France). SPOT satellite images (acquired at low tide in spring or autumn between 1986 and 1998) were calibrated using in situ radiometric d...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/s1631-0691(03)00125-2
更新日期:2003-04-01 00:00:00
abstract::A model of plant succession has been built for simulating the growth of six species, based on physiological processes such as photosynthesis, growth and maintenance respiration, carbon allocation, nitrogen absorption, fixation and remobilisation, organ mortality, seed dispersal and germination. The simulated global pl...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2005.07.008
更新日期:2006-01-01 00:00:00
abstract::Why was sexual selection so important to Darwin? And why was it de-emphasized by almost all of Darwin's followers until the second half of the 20th century? These two questions shed light on the complexity of the scientific tradition named "Darwinism". Darwin's interest in sexual selection was almost as old as his dis...
journal_title:Comptes rendus biologies
pub_type: 传,历史文章,杂志文章
doi:10.1016/j.crvi.2009.12.001
更新日期:2010-02-01 00:00:00
abstract::Enhanced stop codon readthrough is a potential treatment strategy for diseases caused by nonsense mutations. Here, we compare readthrough levels induced by three types of factors: aminoglycoside antibiotics, suppressor tRNAs, and factors decreasing translation termination efficiency. We show that the highest levels of...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2006.09.001
更新日期:2007-01-01 00:00:00