Abstract：
:Enhanced stop codon readthrough is a potential treatment strategy for diseases caused by nonsense mutations. Here, we compare readthrough levels induced by three types of factors: aminoglycoside antibiotics, suppressor tRNAs, and factors decreasing translation termination efficiency. We show that the highest levels of readthrough were obtained by prolonged treatment with aminoglycosides and suppressor tRNAs, whereas prolonged depletion of release factors induced only a moderate increase in readthrough. We discuss the benefits and inconvenients of the three types of factors for their use in the therapy of diseases caused by premature stop codons.
journal_name
C R Bioljournal_title
Comptes rendus biologiesauthors
Diop D,Chauvin C,Jean-Jean Odoi
10.1016/j.crvi.2006.09.001subject
Has Abstractpub_date
2007-01-01 00:00:00pages
71-9issue
1eissn
1631-0691issn
1768-3238pii
S1631-0691(06)00228-9journal_volume
330pub_type
杂志文章abstract：:An agent-based model (AMB) used to simulate the spread of Human African Trypanosomiasis is presented together with the results of simulations of a focus of the disease. This model is a completely spatialized approach taking into account a series of often overlooked parameters such as human behaviour (activity-related ...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2003.12.002
更新日期：2004-01-01 00:00:00
abstract：:Eutypa dieback (dying arm disease, eutypiosis) is a very devastating disease in many grape-producing areas around the world. This vascular disease is induced by the ascomycete Eutypa lata Pers. Fr. Tul & C. Tul. invading the trunk by pruning wounds. The environmental factors and the nutritional requirements regulating...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2005.01.006
更新日期：2005-03-01 00:00:00
abstract：:The polymorphism of the mitochondrial gene cytochrome oxidase III was studied in the Mediterranean octopus, Octopus vulgaris Cuvier, 1797. A total of 202 specimens from seven sampling sites were analysed with the aim of elucidating patterns of genetic structure in the central Mediterranean Sea and to give an insight i...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2012.10.004
更新日期：2012-10-01 00:00:00
abstract：:The spatial variation of soil pH and soil organic matter (SOM) in the urban area of Xuzhou, China, was investigated in this study. Conventional statistics, geostatistics, and a geographical information system (GIS) were used to produce spatial distribution maps and to provide information about land use types. A total ...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2014.02.008
更新日期：2014-05-01 00:00:00
abstract：:The intestinal microbiota is essential for digestion, the production of physiological metabolites, and defense. More than 1013 bacteria are present in the intestine, inspiring awe as well as fear of potential infections. By definition, the immune system protects us from infection, and is given the task to recognize da...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2018.03.003
更新日期：2018-01-01 00:00:00
abstract：:During the analysis of alien and invasive flora of Europe, as a threat to biodiversity, data for Croatia were missing. The aim of our research was to analyse distributional patterns and range size of all invasive alien plants (64) for the state area (57,000 km(2)). They were detected on 49% of the state territory, ave...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2013.01.003
更新日期：2013-02-01 00:00:00
abstract：PURPOSE:The aim of this study was to monitor in vivo with low field MRI growth of a murine orthotopic glioma model following a suicide gene therapy. METHODS:The gene therapy consisted in the stereotactic injection in the mice brain of a modified vaccinia virus Ankara (MVA) vector encoding for a suicide gene (FCU1) tha...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2009.12.012
更新日期：2010-03-01 00:00:00
abstract：:The objective of this study is to investigate the genetic diversity, the relationships among six Tunisian wild cardoon populations (Cynara cardunculus var. sylvestris) and a Tunisian's population of cultivated cardoon (Cynara cardunculus var. altilis DC) in seven different geographical locations (Tiurif, Bahra, Zriba,...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2012.04.005
更新日期：2012-06-01 00:00:00
abstract：:We used self-organizing maps (SOM, neural network) to bring out patterns of benthic macroinvertebrate diversity in relation to river pollution. Fourteen stations were sampled over various seasons in the Nestore drainage basin (Central Italy) and characterized for macroinvertebrate communities, nutrient and heavy metal...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2015.04.006
更新日期：2015-07-01 00:00:00
abstract：:To infer the anatomical evolution of the Hymenophyllaceae (filmy ferns) and to test previously suggested scenarios of regressive evolution, we performed an exhaustive investigation of stem anatomy in the most variable lineage of the family, the trichomanoids, using a representative sampling of 50 species. The evolutio...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2011.07.009
更新日期：2011-12-01 00:00:00
abstract：:Several studies have demonstrated that, in a context of oxidative stress, resveratrol, a polyphenol found in wine, could act as a protective agent on endothelial cells by various mechanisms but without showing that it could penetrate inside the cell. The aim of this study was to detect for the first time resveratrol i...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2012.03.013
更新日期：2012-04-01 00:00:00
abstract：:13C- and deuterium (D)-labeled ferulic acid and sinapic acid ([8-(13)C, 3-OCD3]-ferulic acid and [8-(13)C, 3,5-OCD3]-sinapic acid) were administered to robinia (Robinia pseudoacacia L.) shoots. To estimate the distribution of the label from administrated ferulic or sinapic acid, continuous 50-microm-thick tangential s...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2004.07.012
更新日期：2004-09-01 00:00:00
abstract：:Phylogeny, be it morphological or molecular, has long tried to explain the extant biodiversity by the Tree of Species, which is a logical consequence of strict Darwinian evolutionary principles. Through constant improvement of both methods and data sets, some parts of this diversity have actually been demonstrated to ...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2008.07.003
更新日期：2009-02-01 00:00:00
abstract：:Mussels of the subfamily Bathymodiolinae thrive around chimneys emitting hot fluids at deep sea hydrothermal vents, as well as at cold seeps and on sunken organic debris (sunken wood, whale falls). Despite the absence of light-driven primary production in these deep-sea ecosystems, mussels succeed reaching high biomas...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2008.08.003
更新日期：2009-02-01 00:00:00
abstract：:The use of fluctuating asymmetry (FA) to reveal environmental stress in natural populations has been investigated extensively over the past decade. In aquatic ecosystems, many investigations involve amphibiotic insects with larval development stages in freshwater. To explain the important variability in study results,...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2005.09.002
更新日期：2005-10-01 00:00:00
abstract：:More than 5 years after the description of the first cases of variant Creutzfeldt-Jakob disease (vCJD), there is still great uncertainty about the size of the vCJD epidemic in the United Kingdom (UK), although the most recent predictions based on statistical modelling are more optimistic than the previous ones. The nu...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/s1631-0691(02)01410-5
更新日期：2002-01-01 00:00:00
abstract：:The paper provides a mathematical study of a model of urban dynamics, adjusting to an ecological model proposed by Lotka and Volterra. The model is a system of two first-order non-linear ordinary differential equations. The study proposed here completes the original proof by using the main tools such as a Lyapunov fun...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2004.09.006
更新日期：2004-11-01 00:00:00
abstract：:Patterns of wear on the canine teeth were examined in 260 adult male babirusa skulls. Video recordings of 161 adult male babirusas at salt licks in North Sulawesi were viewed for behaviour related to erosion of the canine teeth. Corresponding observations were made of the behaviour of male babirusa in Antwerp and Sura...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2017.03.006
更新日期：2017-05-01 00:00:00
abstract：:This work assesses the impact of the use of chicken manure and irrigation water on the toxicological quality of Solanum macrocarpon, a highly appreciated vegetable. A control site in Glo-Djigbé, gardeners' sites at Houéyiho, Fidjrossè, and Agongbomey were included in the study. Lead has been sought in the environment ...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2013.04.006
更新日期：2013-05-01 00:00:00
abstract：:Despite the fact that coverage is one of the most widely used descriptors for seagrass meadows, the spatial structure of coverage at mesoscale has not often been taken into account. The present work investigates the structure of P. oceanica coverage at mesoscale and its possible relationship with several factors (dept...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2006.05.001
更新日期：2006-09-01 00:00:00
abstract：:Using protein loci and DNA markers, we show by a multilocus genetic analysis that certain populations of the two sympatric mouse species Mus musculus domesticus and Mus spretus show clear signs of partial introgression. Given the sterility of F1 males and the known partial genetic incompatibilities between the genomes...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/s1631-0691(02)01413-0
更新日期：2002-02-01 00:00:00
abstract：:Any clinician dreams to obtain the regeneration of the destroyed organ for his patient. In the human being, the regeneration of complex structures is not possible, except the liver and the bone marrow, which can be regenerated because of the presence of adult stem cells in these tissues. The stem cells have two princi...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2007.07.001
更新日期：2007-09-01 00:00:00
abstract：:Ancientness and maturity are two major qualities of forest ecosystems. They are components of naturalness and are affected by human impact. These qualities and the associated terms are often mixed up and incorrectly used. We have carried out a synthesis in order to propose an adapted French terminology based on intern...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2014.10.004
更新日期：2015-01-01 00:00:00
abstract：:This article demonstrates how that the effectiveness of nervous system in doing the computations essential to an organism can be based on using algorithms that are readily implemented by nervous system 'device biophysics'. Collective effects and collective algorithms that exploit their dynamics provide powerful potent...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/s1631-0691(03)00017-9
更新日期：2003-02-01 00:00:00
abstract：:Epilithic diatom communities are particularly suitable for the evaluation of freshwater quality. In Ecuador, however, no water quality index includes this biotic parameter. This work is the first attempt in the country to determine the composition of epilithic diatom communities associated with different degrees of eu...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2018.03.008
更新日期：2018-04-01 00:00:00
abstract：:Male infertility is the cause in half of all childless partnerships. Numerous factors contribute to male infertility, including chromosomal aberrations and gene defects. Few data exist regarding the association of these chromosomal aberrations with male infertility in Arab and North African populations. We therefore a...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2014.02.006
更新日期：2014-04-01 00:00:00
abstract：:To determine if a type of unicoloniality exists in the fire ant Solenopsis saevissima in its native range, we conducted intraspecific aggressiveness tests in French Guiana between workers originating from 15 human-disturbed sites. We identified two "colonial groups" spread over 54 km and 12.5 km, respectively. Workers...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2011.01.007
更新日期：2011-04-01 00:00:00
abstract：:Data on mineral elements in spirulinas being limited, we analyzed macrominerals and trace elements of samples from France and Africa. Spirulinas cultivated in France have a composition in macromineral elements similar to those of the literature. The entire contents of trace elements are low. Unlike marine cyanobacteri...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2013.11.004
更新日期：2014-01-01 00:00:00
abstract：:Pleistocene climatic changes shaped the patterns of biodiversity in Europe and around the Mediterranean. Describing the phylogeographic structure of animal populations and inferring past population dynamics is essential to develop a framework for conservation biology in Europe. Direct persecution, habitat loss, popula...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/s1631-0691(03)00038-6
更新日期：2003-08-01 00:00:00
abstract：:In the present study, we have screened 71, 713, 525, 119 and 241 mature miRNA variants from Hordeum vulgare, Oryza sativa, Brachypodium distachyon, Triticum aestivum, and Sorghum bicolor, respectively, and classified them with respect to their conservation status and expression levels. These Poaceae non-redundant miRN...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2016.05.011
更新日期：2016-09-01 00:00:00
