Abstract：
:Members of the APOBEC family of cellular polynucleotide cytidine deaminases (e.g., APOBEC3G) are potent inhibitors of HIV infection. Wild type viral infections are largely spared from APOBEC function through the action of the viral Vif protein. In Vif's absence, inhibitory APOBEC proteins are encapsidated by budding virus particles leading to excessive cytidine (C) to uridine (U) hypermutation of negative sense reverse transcripts in newly infected cells. This registers as guanosine (G) to adenosine (A) mutations in plus stranded cDNA. Because the functions of Vif and APOBEC proteins oppose each other, it is likely that fluctuations in the Vif/APOBEC balance can influence the natural history of HIV infection. Experimental support for this notion would further justify and stimulate drug discovery initiatives in this area.
journal_name
C R Bioljournal_title
Comptes rendus biologiesauthors
Malim MHdoi
10.1016/j.crvi.2006.01.012subject
Has Abstractpub_date
2006-11-01 00:00:00pages
871-5issue
11eissn
1631-0691issn
1768-3238pii
S1631-0691(06)00187-9journal_volume
329pub_type
杂志文章abstract：:Two ground-dwelling couas species, Coquerel's Coua Coua coquereli and Giant Coua Coua gigas, live in sympatry in the dry forest of Madagascar. These birds are typically insectivorous and mainly feed at ground level. The two species differ by size but have the same morphology, suggesting they have the same physical att...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2009.01.005
更新日期：2009-06-01 00:00:00
abstract：:To determine if a type of unicoloniality exists in the fire ant Solenopsis saevissima in its native range, we conducted intraspecific aggressiveness tests in French Guiana between workers originating from 15 human-disturbed sites. We identified two "colonial groups" spread over 54 km and 12.5 km, respectively. Workers...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2011.01.007
更新日期：2011-04-01 00:00:00
abstract：:We used self-organizing maps (SOM, neural network) to bring out patterns of benthic macroinvertebrate diversity in relation to river pollution. Fourteen stations were sampled over various seasons in the Nestore drainage basin (Central Italy) and characterized for macroinvertebrate communities, nutrient and heavy metal...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2015.04.006
更新日期：2015-07-01 00:00:00
abstract：:The development of molecular biology placed in the foreground a mechanistic and deterministic conception of the functioning of macromolecules. In this article, I show that this conception was neither obvious, nor necessary. Taking Jacques Monod as a case study, I detail the way he gradually came loose from a statistic...
journal_title：Comptes rendus biologies
pub_type： 历史文章,杂志文章
doi：10.1016/j.crvi.2015.03.008
更新日期：2015-06-01 00:00:00
abstract：:An efficient method of regeneration for antidiabetic plant (Stevia rebaudiana) has been established for healthy biomass and main steviol glycosides (SGs) production, using different PGRs and agar concentrations. Higher callus induction (93.3%) was recorded when leaf explants were placed on an MS medium supplemented wi...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2013.10.002
更新日期：2013-10-01 00:00:00
abstract：:Why was sexual selection so important to Darwin? And why was it de-emphasized by almost all of Darwin's followers until the second half of the 20th century? These two questions shed light on the complexity of the scientific tradition named "Darwinism". Darwin's interest in sexual selection was almost as old as his dis...
journal_title：Comptes rendus biologies
pub_type： 传,历史文章,杂志文章
doi：10.1016/j.crvi.2009.12.001
更新日期：2010-02-01 00:00:00
abstract：:The intestinal microbiota is essential for digestion, the production of physiological metabolites, and defense. More than 1013 bacteria are present in the intestine, inspiring awe as well as fear of potential infections. By definition, the immune system protects us from infection, and is given the task to recognize da...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2018.03.003
更新日期：2018-01-01 00:00:00
abstract：:This study aimed at showing the applicability of using a combination of four sampling methods (i.e., Winkler extractors, pitfall traps, baiting and manual collection), something most often conducted in the tropics, to create an inventory of ant species diversity in temperate environments. We recorded a total of 33 ant...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2007.08.012
更新日期：2007-12-01 00:00:00
abstract：:A mitochondrial and nuclear gene analysis allowed us to precise the taxonomical position of the two sympatric species of mice known to be present on Cyprus. One of them is the commensal house mouse M. m. domesticus, and the other revealed to be a new taxon that is a sister species of M. spicilegus and M. macedonicus. ...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2004.03.001
更新日期：2004-05-01 00:00:00
abstract：:The voltage-gated sodium channel (VGSC) is a complex, which is composed of one pore-forming α subunit and at least one β subunit. Up to now, five β subunits are known: β1/β1A, β1B, β2, β3, and β4, encoded by four genes (SCN1B∼SCN4B). It is critical to have a deep understanding of the interaction between β1 and β3 subu...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2013.11.009
更新日期：2014-02-01 00:00:00
abstract：:Cnidarians (corals and sea anemones) harbouring photosynthetic microalgae derive several benefits from their association. To allow this association, numerous symbiotic-dependent adaptations in both partners, resulting from evolutionary pressures, have been selected. The dinoflagellate symbionts (zooxanthellae) are loc...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2018.03.007
更新日期：2018-01-01 00:00:00
abstract：:The Chinese genome project was initiated in 1993 with the goal of contributing 1% to the Human Genome Program. The study of gene expression profiles with cDNA microarrays, and large-scale sequencing and analysis of 130928 expressed sequence tags (ESTs), allowed isolation and characterization of over 1000 novel full-le...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2003.09.021
更新日期：2003-10-01 00:00:00
abstract：:The authors' purpose will be here to underline the continuity of the adaptative processes that make Homo sapiens, sometimes a brilliant inventor, sometimes a mere imitator, forging tools already conceived by Nature itself. ...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2007.06.006
更新日期：2007-10-01 00:00:00
abstract：:Exploiting the annotation of the western clawed frog Silurana tropicalis genome, we identified a new metallothionein (MT) gene, exhibiting all the features to be considered an active gene, but with an atypical coding region, showing only 17 cysteine residues instead of the canonical 20 cysteines of vertebrate metallot...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2015.03.011
更新日期：2015-05-01 00:00:00
abstract：:This article is the result of a symposium organized at the French Academy of Sciences on May 31, 2016, entitled: Do we need to know the causes to understand and intervene? Questions on causality in the biological and medical sciences, and published in French in a book entitled: Causality in the biological and medical ...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2019.03.001
更新日期：2019-01-01 00:00:00
abstract：:Policy for biodiversity conservation must evolve to cope with the increasing human footprint on natural systems. A major issue here is the need for policy for protected areas, which integrates their surrounding landscape and local human populations in the construction of socially grounded measures. To illustrate curre...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2011.02.001
更新日期：2011-05-01 00:00:00
abstract：:An agent-based model (AMB) used to simulate the spread of Human African Trypanosomiasis is presented together with the results of simulations of a focus of the disease. This model is a completely spatialized approach taking into account a series of often overlooked parameters such as human behaviour (activity-related ...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2003.12.002
更新日期：2004-01-01 00:00:00
abstract：:Although there are many types of epilepsy of both genetic and acquired forms, temporal lobe epilepsy (TLE) with hippocampal sclerosis is probably the single most common human epilepsy, and the one most intensely studied. Despite a wealth of descriptive data obtained from patient histories, imaging techniques, electroe...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2004.10.010
更新日期：2005-02-01 00:00:00
abstract：:Pleistocene climatic changes shaped the patterns of biodiversity in Europe and around the Mediterranean. Describing the phylogeographic structure of animal populations and inferring past population dynamics is essential to develop a framework for conservation biology in Europe. Direct persecution, habitat loss, popula...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/s1631-0691(03)00038-6
更新日期：2003-08-01 00:00:00
abstract：:Hardwood trees are able to reorient their axes owing to tension wood differentiation. Tension wood is characterised by important ultrastructural modifications, such as the occurrence in a number of species, of an extra secondary wall layer, named gelatinous layer or G-layer, mainly constituted of cellulose microfibril...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2004.07.006
更新日期：2004-09-01 00:00:00
abstract：:13C- and deuterium (D)-labeled ferulic acid and sinapic acid ([8-(13)C, 3-OCD3]-ferulic acid and [8-(13)C, 3,5-OCD3]-sinapic acid) were administered to robinia (Robinia pseudoacacia L.) shoots. To estimate the distribution of the label from administrated ferulic or sinapic acid, continuous 50-microm-thick tangential s...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2004.07.012
更新日期：2004-09-01 00:00:00
abstract：:Zearaja chilensis has been reported from Southern Brazil in the Southwest Atlantic (SWA) to northern Chile in the Southeast Pacific (SEP), and it was listed as vulnerable by the IUCN. Recent molecular studies have called into question the conspecificity between specimens from these opposite coasts of South America, wh...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2018.10.002
更新日期：2018-01-01 00:00:00
abstract：:The genetic diversity analysis of 90 barley samples, including 45 wild close relatives of barley from the Tibet region of China and 45 wild accessions from different countries throughout the Middle East, were carried out using ISSR and SSR markers. The results showed that Tibetan wild close relatives of barley had a h...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2008.11.007
更新日期：2009-04-01 00:00:00
abstract：:A number of different neuropeptides exert powerful concerted controls on feeding behavior and energy balance, most of them being produced in hypothalamic neuronal networks under stimulation by anabolic and catabolic peripheral hormones such as ghrelin and leptin, respectively. These peptide-expressing neurons intercon...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2006.03.021
更新日期：2006-08-01 00:00:00
abstract：:The use of fluctuating asymmetry (FA) to reveal environmental stress in natural populations has been investigated extensively over the past decade. In aquatic ecosystems, many investigations involve amphibiotic insects with larval development stages in freshwater. To explain the important variability in study results,...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2005.09.002
更新日期：2005-10-01 00:00:00
abstract：:Alloscorpiops (Laoscorpiops) calmonti subgen. n., sp. n., belonging to the family Euscorpiidae Laurie, is described on the basis of single female specimen collected in the Pathoumphone District of southern Laos. This new scorpion taxon may represent yet another endemic element for the fauna of Laos. The new subgenus i...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2013.01.001
更新日期：2013-01-01 00:00:00
abstract：:A numerical simulation for the dynamics of a model that describes the sexual phase of Monogonont Rotifera reproduction is presented. The simulation is carried out by means of a numerical method based on the integration along the characteristic curves. The numerical experiments cover two basic situations: the existence...
journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2003.08.006
更新日期：2004-03-01 00:00:00
abstract：:The paper provides a mathematical study of a model of urban dynamics, adjusting to an ecological model proposed by Lotka and Volterra. The model is a system of two first-order non-linear ordinary differential equations. The study proposed here completes the original proof by using the main tools such as a Lyapunov fun...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2004.09.006
更新日期：2004-11-01 00:00:00
abstract：:I here provide some field observations and literature data showing that egg laying site availability could be the main limiting factor for most arboreal gecko population dynamics. Several natural (typhoons, volcanism, sea level variations) or human-mediated habitat modifications (garden openings in forested areas) pro...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2009.11.005
更新日期：2010-01-01 00:00:00
abstract：:We have isolated a cardiomyogenic cell line (CMG cell) from murine bone marrow mesenchymal stem cells. The cells showed a fibroblast-like morphology, but the morphology changed after 5-azacytidine exposure. They began spontaneous beating after 2 weeks, and expressed ANP and BNP. Electron microscopy revealed a cardiomy...
journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/s1631-0691(02)01524-x
更新日期：2002-10-01 00:00:00
