Abstract:
OBJECTIVES:The global health status of older patients with cancer influences their clinical course, but little is known regarding the influence of the immune system on the global health of older patients with cancer. The goal of this study was to assess the relationships between patient fitness/frailty status and survival, and the local tumour immune environment of older patients with breast cancer. MATERIALS AND METHODS:In a cohort of 58 older patients with breast cancer (over 70 years of age), fluorescence microscopy was used to investigate whether levels of intra-tumoural T cells (CD3+) and granulocytic cells (CD15+) could predict clinical outcome, and/or whether they correlated with patient physical and mental performance as evaluated by comprehensive geriatric assessment. RESULTS:We observed that patients with higher levels of intra-tumoural T cells were fitter according to a number of clinical health measures including G8 (p = 0.006), Karnofsky Index (p = 0.0372), and Leuven Oncology Frailty Score (LOFS) (p = 0.0187). In contrast, high relative levels of granulocytic cells were found in patients with poorer clinical health (LOFS, p = 0.0474). Furthermore, high levels of T cells but not granulocytic cells were associated with longer breast cancer-specific survival (p = 0.0444). CONCLUSIONS:This is the first study to show that low relative levels of intra-tumoural T cells are associated with inferior patient fitness. In contrast to T cells, we observed that intra-tumoural granulocytic cells displayed an inverse relationship with patient performance. Further research is needed to determine whether boosting the level of intra-tumoural T cells in older non-fit patients can result in improved outcome.
journal_name
J Geriatr Oncoljournal_title
Journal of geriatric oncologyauthors
Speigl L,Grieb A,Janssen N,Hatse S,Brouwers B,Smeets A,Floris G,Bailur JK,Kenis C,Neven P,Wildiers H,Pawelec G,Shipp Cdoi
10.1016/j.jgo.2018.03.021subject
Has Abstractpub_date
2018-11-01 00:00:00pages
606-612issue
6eissn
1879-4068issn
1879-4076pii
S1879-4068(18)30135-8journal_volume
9pub_type
杂志文章,多中心研究abstract::Data regarding management of frail patients with pancreatic ductal adenocarcinoma practice is currently very scarce. Randomized clinical trials usually exclude these subgroup of patients and the majority of the publications only consider chronological age and ECOG performance status for their classification. Therefore...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章,评审
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journal_title:Journal of geriatric oncology
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abstract:OBJECTIVE:Clinical trials investigating breast cancer treatment often exclude or misrepresent older adults. This study compares treatment patterns and survival of older women diagnosed with breast cancer between a Dutch and a British observational cohort. MATERIALS AND METHODS:Women aged 70 years and older diagnosed w...
journal_title:Journal of geriatric oncology
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journal_title:Journal of geriatric oncology
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journal_title:Journal of geriatric oncology
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journal_title:Journal of geriatric oncology
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journal_title:Journal of geriatric oncology
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journal_title:Journal of geriatric oncology
pub_type: 杂志文章,评审
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journal_title:Journal of geriatric oncology
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更新日期:2018-01-01 00:00:00
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journal_title:Journal of geriatric oncology
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journal_title:Journal of geriatric oncology
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doi:10.1016/j.jgo.2019.05.020
更新日期:2020-01-01 00:00:00
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journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2019.02.010
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abstract:INTRODUCTION:In general, geriatric assessment (GA) provides the combined information on comorbidity and functional, nutritional and psychosocial status and may be predictive for mortality outcome of cancer patients. The impact of geriatric assessment on the outcome of older patients with colorectal cancer treated with ...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2013.04.001
更新日期:2013-07-01 00:00:00
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journal_title:Journal of geriatric oncology
pub_type: 杂志文章,评审
doi:10.1016/j.jgo.2018.08.001
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journal_title:Journal of geriatric oncology
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journal_title:Journal of geriatric oncology
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journal_title:Journal of geriatric oncology
pub_type: 杂志文章
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journal_title:Journal of geriatric oncology
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journal_title:Journal of geriatric oncology
pub_type: 临床试验,杂志文章
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journal_title:Journal of geriatric oncology
pub_type: 杂志文章
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更新日期:2019-09-01 00:00:00
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journal_title:Journal of geriatric oncology
pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
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journal_title:Journal of geriatric oncology
pub_type: 杂志文章,多中心研究
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journal_title:Journal of geriatric oncology
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journal_title:Journal of geriatric oncology
pub_type: 杂志文章,meta分析,评审
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abstract:OBJECTIVE:This study aims to identify Comprehensive Geriatric Assessment (CGA) based risk factors to help predict caregiver burden among elderly patients with cancer. MATERIALS AND METHOD:The study evaluated 249 patients newly diagnosed with cancer, aged 70years and above, who attended the geriatric oncology clinic at...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2016.03.003
更新日期:2016-05-01 00:00:00