Abstract：
INTRODUCTION:Older adults with cancer are at increased risk of delirium due to age, comorbidities, medications, cognitive impairment, and possibly cancer treatments. However, there is scant information on the risks of delirium with chemotherapy and approaches to prevent or treat it. We performed a systematic review and meta-analysis to summarize available evidence. MATERIALS AND METHODS:We systematically searched peer-reviewed journal articles in English, French, German, and Dutch from five databases from 1990 to May 2019 to identify studies examining delirium in adult patients receiving chemotherapy. We also attempted to identify delirium risk prediction models and prevention or treatment trials. All reviews and data extraction were performed by two independent reviewers. Summary estimates were derived from random effects models. RESULTS:A total of 23,389 titles and abstracts were screened, and 1272 full-text articles were reviewed. Nineteen articles reported on delirium using an acceptable diagnostic standard. Sample sizes varied from 7 to 324. The incidence of delirium ranged from 0 to 51% (weighted mean 9%, 95% confidence interval 5-16%). In a sensitivity analysis including 122 studies that used terminology suggestive of delirium but did not meet our inclusion criteria, the weighted incidence of delirium was 10% (95% confidence interval 8-12%). Age was not consistently associated with increased delirium risk. No intervention studies to prevent or treat delirium were identified. CONCLUSIONS:Delirium may occur in 1 in 11 older adults receiving chemotherapy; however, there were substantial limitations in reported studies. This systemic review highlights key gaps in knowledge, particularly regarding risk factors, prevention, and treatments.
journal_name
J Geriatr Oncoljournal_title
Journal of geriatric oncologyauthors
Jung P,Puts M,Frankel N,Syed AT,Alam Z,Yeung L,Malik U,Rosario C,Ayala AP,Hudson J,Alibhai SMHdoi
10.1016/j.jgo.2020.08.011subject
Has Abstractpub_date
2020-09-14 00:00:00eissn
1879-4068issn
1879-4076pii
S1879-4068(20)30425-2pub_type
杂志文章abstract：:Current research efforts focusing on improving outcomes of older adults with cancer lack the appropriate infrastructure to support this growing need. The Cancer and Aging Group R21/33 National Institute of Health (NIH)/National Institute of Aging (NIA) grant aims to support development of geriatric oncology research t...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.07.019
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:Cancer in the aging population presents manifold challenges. In the resource-limited settings of developing countries, concrete steps to optimize care for older adults with cancer are required. MATERIALS AND METHOD:This prospective, observational study was divided in two parts. In the first part, older adul...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.04.013
更新日期：2021-01-01 00:00:00
abstract：OBJECTIVE:The G8 is a screening test to identify frail elderly patients with cancer. Objectives were to design and evaluate the performance of alternative tests taking into account other predictive domains for frailty. METHODS:We conducted a literature review to identify predictive factors of frailty. Using a Delphi c...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2016.01.004
更新日期：2016-03-01 00:00:00
abstract：:With a median age of 70 years at diagnosis, lung cancer is a disease of older persons. As a consequence oncologists are confronted with an increasing older lung cancer population for which treatment decisions are needed. In the past years, the therapeutic landscape of advanced non-small cell lung cancer (NSCLC) has ch...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,评审
doi：10.1016/j.jgo.2018.09.008
更新日期：2019-07-01 00:00:00
abstract：OBJECTIVE:Suboptimal adherence with endocrine treatment for breast cancer is influenced by a number of factors but remains poorly understood. We sought to describe the prior knowledge about and expectations of breast cancer treatments among older women retrospecting on their diagnosis and treatment. METHODS:Thematic a...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.07.024
更新日期：2020-04-01 00:00:00
abstract：:The "Cadillac Study" was the term Arti Hurria, MD often used to articulate her vision of the optimal study to investigate the effects of cancer and its treatments on aging trajectories. In her opinion, this study needed to be designed for near-term clinical translation and have the ability to discern subpopulations of...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.06.009
更新日期：2020-03-01 00:00:00
abstract：:It is well recognized that the incidence of breast cancer increases significantly with age. Despite this, older people remain under-represented in many clinical trials and their management relies on extrapolation of data from younger patients. Providing an aggressive intervention can be challenging, particularly in le...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,评审
doi：10.1016/j.jgo.2017.05.004
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:Geriatric assessment (GA) is an appropriate method for identifying frailty in older patients with cancer, but a shorter instrument may be easier to use in clinical practice. Clinical judgment is always available and requires no investments in time or resources. The purpose of this study was to assess correla...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.05.011
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:A geriatric assessment (GA) is increasingly used to help guide treatment decisions in older patients with cancer. However, there is no consensus regarding which domains should be included in the GA. In addition, the field of geriatric oncology moves very fast and as a result many new studies have been publis...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.02.010
更新日期：2019-11-01 00:00:00
abstract：OBJECTIVES:Increasing evidence suggests that statins may have antitumor effects but their role in rectal cancer appears inconclusive. The aim of this study was to investigate whether statins may have an impact on survival of older and younger patients with rectal cancer. MATERIALS AND METHODS:This study included 238 p...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.01.011
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVES:Little is known about how psychosocial factors and distress affect older patients with cancer and their survival. The study goals were to: 1) observe the prevalence of anxiety (ANX) and depression (DEP) symptoms at diagnosis in patients aged ≥65 years, 2) observe the association between social isolation (iso...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.10.001
更新日期：2020-11-04 00:00:00
abstract：:The incidence of multiple myeloma (MM) increases with age, and with the aging of the population, the number of adults with MM is expected to double in the next 20 years. Novel agents, including the immunomodulatory agents thalidomide and lenalidomide, and the proteosome inhibitor bortezomib have dramatically changed t...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2012.02.001
更新日期：2012-07-01 00:00:00
abstract：:Older cancer survivors may experience ageing at an accelerated rate when compared to their similar-aged, cancer-free counterparts. Ageing is undoubtedly a significant risk factor for cancer. There is evidence to suggest, however, that this relationship may in fact be bidirectional, with cancer and its treatments contr...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,评审
doi：10.1016/j.jgo.2020.09.010
更新日期：2020-09-12 00:00:00
abstract：PURPOSE:Although the year after cancer treatment is challenging for all cancer survivors, older adults (≥60 years) face additional challenges due to age-related decline and high rates of comorbidity. There is a paucity of research on how health service interruptions from the COVID-19 pandemic have impacted the experien...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.11.009
更新日期：2020-12-03 00:00:00
abstract：OBJECTIVES:We investigated whether advanced age affects peri-operative outcomes after robotic-assisted pulmonary lobectomies. MATERIALS AND METHODS:We retrospectively analyzed patients who underwent robotic-assisted lobectomy by one surgeon over a 5-year period. Rates of postoperative complications were compared accor...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2016.11.003
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVES:The global health status of older patients with cancer influences their clinical course, but little is known regarding the influence of the immune system on the global health of older patients with cancer. The goal of this study was to assess the relationships between patient fitness/frailty status and survi...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jgo.2018.03.021
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:Metastasectomy has a curative potential in colon cancer, but its benefits have not been ascertained in population data. Our objective was to evaluate utilization of metastasectomy in colon cancer and its survival outcomes in groups defined by different age at diagnosis, tumor grade or varying extent of nodal...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2015.08.002
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Older patients are at risk for adverse outcomes after surgical treatment of cancer. Identifying patients at risk could affect treatment decisions and prevent functional decline. Screening tools are available to select patients for Geriatric Assessment. Until now their predictive value for adverse outcomes in...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jgo.2017.09.003
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVE:This study aims to (1) describe the activities, function, and health-related quality of life (HRQOL) of a large sample of older adults (age ≥65) with cancer, (2) identify the associations with demographics, cancer type, comorbid conditions, and ability to participate in activities and functional status. MATE...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2017.02.009
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Regorafenib significantly increases overall survival (OS) in patients with metastatic colorectal cancer previously treated but gives toxicities. OBJECTIVES:to assess the efficacy and safety of regorafenib at it's approved dose in the older population. PATIENTS AND METHODS:This multicenter single-arm phase ...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.04.001
更新日期：2020-11-01 00:00:00
abstract：:Multidisciplinary teams (MDTs) have been incorporated into the practical care of elderly patients with cancer. Several geriatric oncology centres have attempted to determine the best way to implement MDTs by using geriatric assessment (GA). Developing a geriatric oncology service is a feasible work, which requires sig...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,评审
doi：10.1016/j.jgo.2016.07.001
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVES:The purpose of this study was to develop a new brief, comprehensive geriatric assessment scale for older patients diagnosed with different hematological malignancies, the Geriatric Assessment in Hematology (GAH scale), and to determine its psychometric properties. MATERIALS AND METHODS:The 30-item GAH scale...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jgo.2015.03.003
更新日期：2015-09-01 00:00:00
abstract：OBJECTIVES:Family caregiver burden among older adults with advanced cancer remains poorly understood. We sought to (1) identify patient factors associated with caregiver burden and (2) examine how amount of time caregiving modifies these relationships. METHODS:Cross-sectional analysis of baseline data from a cluster-r...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2021.01.002
更新日期：2021-01-18 00:00:00
abstract：:Older adults with cancer are quickly becoming the largest group of cancer survivors. Chronological age is a poor predictor of cancer treatment outcomes and of the need for rehabilitation services. While newer symptom management systems and assessments are slowly becoming used in the clinic to improve communication bet...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,评审
doi：10.1016/j.jgo.2017.11.009
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVE:This study aims to identify Comprehensive Geriatric Assessment (CGA) based risk factors to help predict caregiver burden among elderly patients with cancer. MATERIALS AND METHOD:The study evaluated 249 patients newly diagnosed with cancer, aged 70years and above, who attended the geriatric oncology clinic at...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2016.03.003
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:Adjuvant! Online is a tool used for clinical decision making in patients with early stage colon cancer. As details of the tool's construction are not published, the ability of Adjuvant! Online to accurately predict outcomes for older patients (age 70+) with node positive colon cancer receiving adjuvant chemo...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2016.07.002
更新日期：2016-11-01 00:00:00
abstract：:The aging of the population is a global challenge. The number of older adults is rapidly growing, leading to an increase in the prevalence of noncommunicable diseases associated with aging, such as cancer. Worldwide, older adults account for approximately half of all cancer cases, and this proportion is projected to i...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,评审
doi：10.1016/j.jgo.2017.06.001
更新日期：2017-09-01 00:00:00
abstract：OBJECTIVES:No tools accurately discriminate between older patients who are fit and those who are frail to tolerate systemic palliative treatment. This study evaluates whether domains of geriatric assessment (GA) are associated with increased risk of chemotherapy intolerance in patients who were considered fit to start ...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.05.016
更新日期：2020-04-01 00:00:00
abstract：OBJECTIVES:Older adults frequently experience falls, at great cost to themselves and society. Older adults with cancer may be at greater risk for falls and have unique risk factors. MATERIALS AND METHODS:We undertook a systematic review of the available medical literature to examine the current evidence regarding fact...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,评审
doi：10.1016/j.jgo.2014.10.003
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVE:Elderly patients with cancer are under-represented in clinical trials, and there is especially scant data on their participation in early-phase trials. In an effort to provide more data, we reviewed our Phase I experience. METHODS:We conducted a retrospective analysis of 461 patients enrolled in Phase I clin...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2013.08.005
更新日期：2014-01-01 00:00:00
