Abstract：
BACKGROUND:Metastasectomy has a curative potential in colon cancer, but its benefits have not been ascertained in population data. Our objective was to evaluate utilization of metastasectomy in colon cancer and its survival outcomes in groups defined by different age at diagnosis, tumor grade or varying extent of nodal spread. METHODS:We extracted data from the Surveillance, Epidemiology and End Results database on adult patients with stage IV colon cancer diagnosed between 2003 and 2011. We analyzed the association of overall survival (OS) with metastasectomy using multivariable Cox models. RESULTS:Among 41,137 patients with stage IV cancer, 26,607 (65%) underwent primary surgery and 5028 (12.2%) underwent metastasectomy. Older patients were less likely to have ≥12 lymph nodes examined in the surgical specimen, but also less likely to have nodal metastases when adequately staged (from 86% for age <50 years to 79% for age ≥85 years). Metastasectomy was less common in older patients (from 18% for age <50 years to 7% for age ≥85 years). OS after resection was inversely associated with age and nodal involvement. The association of metastasectomy with survival was favorable in all age groups (hazard ratio, HR, 0.68-0.72, P<0.0001), but it was not significant for those ≥85y ears old (HR, 0.92, P=0.23). It was also favorable regardless of the extent of nodal spread or tumor grade. CONCLUSIONS:Resection of metastatic site is favorably associated with survival in patients up to 85 years of age. Older patients undergoing metastasectomy are more likely to be node-negative when adequately staged.
journal_name
J Geriatr Oncoljournal_title
Journal of geriatric oncologyauthors
Khan H,Khan N,Ahmad A,Olszewski AJ,Somasundar Pdoi
10.1016/j.jgo.2015.08.002subject
Has Abstractpub_date
2015-11-01 00:00:00pages
446-53issue
6eissn
1879-4068issn
1879-4076pii
S1879-4068(15)00076-4journal_volume
6pub_type
杂志文章abstract：OBJECTIVES:We investigated whether advanced age affects peri-operative outcomes after robotic-assisted pulmonary lobectomies. MATERIALS AND METHODS:We retrospectively analyzed patients who underwent robotic-assisted lobectomy by one surgeon over a 5-year period. Rates of postoperative complications were compared accor...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2016.11.003
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVE:Clinical trials investigating breast cancer treatment often exclude or misrepresent older adults. This study compares treatment patterns and survival of older women diagnosed with breast cancer between a Dutch and a British observational cohort. MATERIALS AND METHODS:Women aged 70 years and older diagnosed w...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2018.05.004
更新日期：2018-11-01 00:00:00
abstract：INTRODUCTION:Older adults are underrepresented in landmark trials that determine treatment guidelines for pancreatic cancer. We used the National Cancer Database (NCDB) to compare treatment patterns and outcomes in stage I-III pancreatic cancer between older adult patients, defined as age 80 or older, to patients young...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.12.006
更新日期：2020-05-01 00:00:00
abstract：:OBJECTIVES: To identify patient characteristics associated with polypharmacy and inappropriate medication (PIM) use among older patients with newly diagnosed cancer. DESIGN: Cross-Sectional Study. SETTING: Ambulatory oncology clinics at an academic medical center. PARTICIPANTS: 117 patients aged ≥ 65 years with new...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2012.02.005
更新日期：2012-07-01 00:00:00
abstract：OBJECTIVES:To investigate changes in inflammatory biomarkers during induction therapy for older adults with acute myeloid leukemia (AML) and their associations with geriatric assessment (GA) measures and outcomes. METHODS:This was a single institution ancillary study to a prospective observational study (N = 20 consec...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.03.014
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:The majority of patients with chronic lymphocytic leukemia (CLL) are older and have multiple comorbidities, including other cancer diagnoses. These patients are routinely excluded from participation in clinical trials. OBJECTIVE:In this phase II study, we determined the activity and toxicity of ofatumumab, ...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.04.002
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVE:This study aims to (1) describe the activities, function, and health-related quality of life (HRQOL) of a large sample of older adults (age ≥65) with cancer, (2) identify the associations with demographics, cancer type, comorbid conditions, and ability to participate in activities and functional status. MATE...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2017.02.009
更新日期：2017-07-01 00:00:00
abstract：PURPOSE:With the aging population, our current understanding of patients with cancer and their family caregivers needs to be expanded to older patients with cancer and their caregivers. By differentiating spousal caregivers and non-spousal caregivers, we aimed to investigate the universalities and particularities of ca...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.05.020
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:A geriatric assessment (GA) is increasingly used to help guide treatment decisions in older patients with cancer. However, there is no consensus regarding which domains should be included in the GA. In addition, the field of geriatric oncology moves very fast and as a result many new studies have been publis...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.02.010
更新日期：2019-11-01 00:00:00
abstract：OBJECTIVE:Sarcopenia is associated with poor outcomes in patients undergoing surgery for pancreatic ductal adenocarcinoma (PDAC). However, few studies have assessed changes in sarcopenia during multimodality therapy or its effect on overall survival (OS). METHODS:Computed tomography (CT) total psoas area index (TPAI) ...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2018.03.002
更新日期：2018-07-01 00:00:00
abstract：:In advising the optimal management for older patients, health care professionals try to balance the risks from frailty, vulnerability, and comorbidity against the patient's ultimate prognosis, potential functional outcomes and quality of life (QOL). At the same time it is important to involve the patient and incorpora...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,评审
doi：10.1016/j.jgo.2018.08.001
更新日期：2018-11-01 00:00:00
abstract：:The "Cadillac Study" was the term Arti Hurria, MD often used to articulate her vision of the optimal study to investigate the effects of cancer and its treatments on aging trajectories. In her opinion, this study needed to be designed for near-term clinical translation and have the ability to discern subpopulations of...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.06.009
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVE:In this study, we evaluated the Groningen Frailty Indicator (GFI) and the G8 questionnaire as screening tools for a Comprehensive Geriatric Assessment (CGA) in older patients with cancer. PATIENTS AND METHODS:Eligible patients with various types and stages of cancer were evaluated for frailty before treatmen...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jgo.2012.08.001
更新日期：2013-01-01 00:00:00
abstract：:BACKGROUND: The current study was undertaken to explore whether older age predicts adverse event rates in metastatic melanoma patients participating in cancer clinical trials. METHODS: Six phase II studies conducted at our institution for patients with metastatic disease were used in these pooled analyses: 1) ABT-510...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2012.04.002
更新日期：2012-10-01 00:00:00
abstract：:It is well recognized that the incidence of breast cancer increases significantly with age. Despite this, older people remain under-represented in many clinical trials and their management relies on extrapolation of data from younger patients. Providing an aggressive intervention can be challenging, particularly in le...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,评审
doi：10.1016/j.jgo.2017.05.004
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:Geriatric assessment (GA) is an appropriate method for identifying frailty in older patients with cancer, but a shorter instrument may be easier to use in clinical practice. Clinical judgment is always available and requires no investments in time or resources. The purpose of this study was to assess correla...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.05.011
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVES:The global health status of older patients with cancer influences their clinical course, but little is known regarding the influence of the immune system on the global health of older patients with cancer. The goal of this study was to assess the relationships between patient fitness/frailty status and survi...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jgo.2018.03.021
更新日期：2018-11-01 00:00:00
abstract：:Older cancer survivors may experience ageing at an accelerated rate when compared to their similar-aged, cancer-free counterparts. Ageing is undoubtedly a significant risk factor for cancer. There is evidence to suggest, however, that this relationship may in fact be bidirectional, with cancer and its treatments contr...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,评审
doi：10.1016/j.jgo.2020.09.010
更新日期：2020-09-12 00:00:00
abstract：:Older adults with cancer are quickly becoming the largest group of cancer survivors. Chronological age is a poor predictor of cancer treatment outcomes and of the need for rehabilitation services. While newer symptom management systems and assessments are slowly becoming used in the clinic to improve communication bet...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,评审
doi：10.1016/j.jgo.2017.11.009
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVES:The influence of older age at diagnosis in combination with race/ethnicity on utilization and results of the 21-gene recurrence score (RS) assay for breast cancer (BC) patients is not fully understood. Our objectives were to evaluate the utilization of RS among older women with BC, the likelihood of a high-r...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.06.004
更新日期：2020-07-07 00:00:00
abstract：BACKGROUND:Cancer in the aging population presents manifold challenges. In the resource-limited settings of developing countries, concrete steps to optimize care for older adults with cancer are required. MATERIALS AND METHOD:This prospective, observational study was divided in two parts. In the first part, older adul...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.04.013
更新日期：2021-01-01 00:00:00
abstract：OBJECTIVES:Family caregiver burden among older adults with advanced cancer remains poorly understood. We sought to (1) identify patient factors associated with caregiver burden and (2) examine how amount of time caregiving modifies these relationships. METHODS:Cross-sectional analysis of baseline data from a cluster-r...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2021.01.002
更新日期：2021-01-18 00:00:00
abstract：:Studies on cancer survival have revealed disparities not only between the elderly and their younger counterparts, but also among the elderly themselves. The aim of this work was to identify sociodemographic, socioeconomic, clinical, and care-related determinants of survival or mortality in older patients with cancer b...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2017.07.007
更新日期：2018-01-01 00:00:00
abstract：INTRODUCTION:Older adults with cancer are at increased risk of delirium due to age, comorbidities, medications, cognitive impairment, and possibly cancer treatments. However, there is scant information on the risks of delirium with chemotherapy and approaches to prevent or treat it. We performed a systematic review and...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.08.011
更新日期：2020-09-14 00:00:00
abstract：:Data regarding management of frail patients with pancreatic ductal adenocarcinoma practice is currently very scarce. Randomized clinical trials usually exclude these subgroup of patients and the majority of the publications only consider chronological age and ECOG performance status for their classification. Therefore...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,评审
doi：10.1016/j.jgo.2018.06.005
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:Adjuvant! Online is a tool used for clinical decision making in patients with early stage colon cancer. As details of the tool's construction are not published, the ability of Adjuvant! Online to accurately predict outcomes for older patients (age 70+) with node positive colon cancer receiving adjuvant chemo...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2016.07.002
更新日期：2016-11-01 00:00:00
abstract：OBJECTIVES:HER2 (human epidermal growth factor receptor 2) is an important biomarker in breast cancer, but its prevalence in elderly women is not well established. Previous studies reported HER2 status based on either immunohistochemistry (IHC) or fluorescent in situ hybridization (FISH) interchangeably. However, the t...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2013.05.007
更新日期：2013-10-01 00:00:00
abstract：:The aging of the population is a global challenge. The number of older adults is rapidly growing, leading to an increase in the prevalence of noncommunicable diseases associated with aging, such as cancer. Worldwide, older adults account for approximately half of all cancer cases, and this proportion is projected to i...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,评审
doi：10.1016/j.jgo.2017.06.001
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:Because of comorbidities and polypharmacy, older patients with cancer have a greater risk of iatrogenic events. We aimed to characterize potential drug-drug interactions (PDIs) and the risk of unplanned hospitalization in older patients with cancer treated with antineoplastic agents (ANAs). METHODS:We analy...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.07.023
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:Regorafenib significantly increases overall survival (OS) in patients with metastatic colorectal cancer previously treated but gives toxicities. OBJECTIVES:to assess the efficacy and safety of regorafenib at it's approved dose in the older population. PATIENTS AND METHODS:This multicenter single-arm phase ...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.04.001
更新日期：2020-11-01 00:00:00
