Abstract：
OBJECTIVE:This study aims to (1) describe the activities, function, and health-related quality of life (HRQOL) of a large sample of older adults (age ≥65) with cancer, (2) identify the associations with demographics, cancer type, comorbid conditions, and ability to participate in activities and functional status. MATERIALS AND METHODS:The Health Registry/Cancer Survivorship Cohort is an institutional database designed to aid cancer survivorship research. The registry includes three measures of patient-reported HRQOL: FACT-G and PROMIS® Global measures for physical and mental health. Other measures included in the registry are cancer type, date from diagnosis, number of comorbid conditions and specific conditions and their limitations in daily activity, and self-reported daily activity/function. RESULTS:Our sample consists of 768 older adults with cancer, mean age 72years, 60% female, and 90% White. Mean scores for HRQOL: FACT-G (85, range: 25-108), PROMIS-physical (48, range: 16-67) and, PROMIS-mental (51, range: 21-67). In multivariable models, Black race, one or more comorbid conditions, and Gastrointestinal cancer (p<.05), and patient- reported decreased levels of activities/function were all independently associated with poor HRQOL (p<.0001). CONCLUSIONS:Older Black adults with cancer, those that have high comorbidity burden, with gastrointestinal cancers and those that report decreased ability to participate in daily activities/function reported poorer HRQOL. As geriatric oncology moves towards trying to identify who may need supportive services, this study demonstrated that a one question patient-reported level of activities and functional ability were independently associated with physical, mental, and cancer-specific HRQOL.
journal_name
J Geriatr Oncoljournal_title
Journal of geriatric oncologyauthors
Pergolotti M,Deal AM,Williams GR,Bryant AL,Bensen JT,Muss HB,Reeve BBdoi
10.1016/j.jgo.2017.02.009subject
Has Abstractpub_date
2017-07-01 00:00:00pages
249-254issue
4eissn
1879-4068issn
1879-4076pii
S1879-4068(17)30035-8journal_volume
8pub_type
杂志文章abstract：:Sexual health and sexual minority status are often undiscussed during oncology visits. Yet, these topics should be addressed in older cancer patients in order to help mitigate the sexual side effects of cancer treatment and to acknowledge - and, at times, help provide - the social support older patients need during th...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,评审
doi：10.1016/j.jgo.2019.08.003
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVES:Clinical outcomes in older adults with metastatic renal cell carcinoma (mRCC) are poorly understood, particularly in the era of targeted therapies. We characterize survival and relevant treatment-related variables in a modern series. MATERIALS AND METHODS:From an institutional database including 562 patient...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2012.11.001
更新日期：2013-04-01 00:00:00
abstract：:OBJECTIVES: To identify patient characteristics associated with polypharmacy and inappropriate medication (PIM) use among older patients with newly diagnosed cancer. DESIGN: Cross-Sectional Study. SETTING: Ambulatory oncology clinics at an academic medical center. PARTICIPANTS: 117 patients aged ≥ 65 years with new...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2012.02.005
更新日期：2012-07-01 00:00:00
abstract：OBJECTIVES:This study aims to investigate the use of chemotherapy with or without bevacizumab in older patients with metastatic colorectal cancer (mCRC) in current daily practice and to identify predictive parameters for treatment-related outcomes. PATIENTS AND METHODS:This is a Belgian multi-centre, observational coh...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jgo.2017.10.002
更新日期：2018-03-01 00:00:00
abstract：:The incidence of multiple myeloma (MM) increases with age, and with the aging of the population, the number of adults with MM is expected to double in the next 20 years. Novel agents, including the immunomodulatory agents thalidomide and lenalidomide, and the proteosome inhibitor bortezomib have dramatically changed t...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2012.02.001
更新日期：2012-07-01 00:00:00
abstract：:Studies on cancer survival have revealed disparities not only between the elderly and their younger counterparts, but also among the elderly themselves. The aim of this work was to identify sociodemographic, socioeconomic, clinical, and care-related determinants of survival or mortality in older patients with cancer b...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2017.07.007
更新日期：2018-01-01 00:00:00
abstract：:With a median age of 70 years at diagnosis, lung cancer is a disease of older persons. As a consequence oncologists are confronted with an increasing older lung cancer population for which treatment decisions are needed. In the past years, the therapeutic landscape of advanced non-small cell lung cancer (NSCLC) has ch...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,评审
doi：10.1016/j.jgo.2018.09.008
更新日期：2019-07-01 00:00:00
abstract：:Data regarding management of frail patients with pancreatic ductal adenocarcinoma practice is currently very scarce. Randomized clinical trials usually exclude these subgroup of patients and the majority of the publications only consider chronological age and ECOG performance status for their classification. Therefore...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,评审
doi：10.1016/j.jgo.2018.06.005
更新日期：2019-05-01 00:00:00
abstract：INTRODUCTION:Randomized trials demonstrated oncologic safety and short-term benefits of laparoscopy. We investigated if the benefit of laparoscopy on short-term outcomes is greater for older adults compared with younger adults. METHODS:We identified all older (≥70 years old) and younger (<70) adults with primary sigmo...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.09.018
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:Although the year after cancer treatment is challenging for all cancer survivors, older adults (≥60 years) face additional challenges due to age-related decline and high rates of comorbidity. There is a paucity of research on how health service interruptions from the COVID-19 pandemic have impacted the experien...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.11.009
更新日期：2020-12-03 00:00:00
abstract：AIMS:To study age-related persistence in postmenopausal women with endocrine-responsive breast cancer treated with tamoxifen (TAM) and aromatase inhibitors (AI). METHODS:Data on 29,245 patients diagnosed with metastatic or non-metastatic breast cancer (BC) and initially treated with TAM or AI between 2004 and 2013 wer...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2016.03.001
更新日期：2016-05-01 00:00:00
abstract：OBJECTIVE:In this study, we evaluated the Groningen Frailty Indicator (GFI) and the G8 questionnaire as screening tools for a Comprehensive Geriatric Assessment (CGA) in older patients with cancer. PATIENTS AND METHODS:Eligible patients with various types and stages of cancer were evaluated for frailty before treatmen...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jgo.2012.08.001
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:The majority of patients with chronic lymphocytic leukemia (CLL) are older and have multiple comorbidities, including other cancer diagnoses. These patients are routinely excluded from participation in clinical trials. OBJECTIVE:In this phase II study, we determined the activity and toxicity of ofatumumab, ...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.04.002
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:With the aging population, our current understanding of patients with cancer and their family caregivers needs to be expanded to older patients with cancer and their caregivers. By differentiating spousal caregivers and non-spousal caregivers, we aimed to investigate the universalities and particularities of ca...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.05.020
更新日期：2020-01-01 00:00:00
abstract：INTRODUCTION:Cognitive impairment (CI) increases chemotherapy toxicity risk with need to understand this association utilizing publicly available short screening tools. We evaluated this utilizing a lower threshold on a short screening tool in older adults with cancer. MATERIALS AND METHODS:We analyzed data from the C...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.10.004
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:Screening tools are used in geriatric oncology to determine who should receive a Comprehensive Geriatric Assessment (CGA). However, in this prospective study, we evaluated the association between geriatric screening results, measured with the G8 and Groningen Frailty Indicator (GFI), and severe treatment tox...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2013.12.004
更新日期：2014-04-01 00:00:00
abstract：:Older cancer survivors may experience ageing at an accelerated rate when compared to their similar-aged, cancer-free counterparts. Ageing is undoubtedly a significant risk factor for cancer. There is evidence to suggest, however, that this relationship may in fact be bidirectional, with cancer and its treatments contr...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,评审
doi：10.1016/j.jgo.2020.09.010
更新日期：2020-09-12 00:00:00
abstract：BACKGROUND:An oncogeriatric approach may affect management of elderly patients with breast cancer. However, little is known about oncogeriatric care in the metastatic setting. Therefore, we performed an international comparison of management of elderly patients with primary metastatic disease who were treated in two di...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jgo.2014.02.005
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVE:To date, most comorbidity studies have analyzed either a subgroup of frequent diseases, or used summary instruments such as the Charlson score or the Cumulative Illness Rating Scale-Geriatric (CIRS-G). Yet, comorbidity is a multidimensional construct and impacts function, treatment tolerance, and survival. We...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2017.07.005
更新日期：2017-09-01 00:00:00
abstract：:Current research efforts focusing on improving outcomes of older adults with cancer lack the appropriate infrastructure to support this growing need. The Cancer and Aging Group R21/33 National Institute of Health (NIH)/National Institute of Aging (NIA) grant aims to support development of geriatric oncology research t...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.07.019
更新日期：2020-03-01 00:00:00
abstract：:Adjuvant chemotherapy improves overall survival (OS) following stereotactic body radiotherapy (SBRT) in patients with early stage non-small cell lung cancer and tumors ≥four cm. Here, we aim to evaluate its role following SBRT in older patients. Patients >70 years diagnosed with clinical stages I-II NSCLC, (N0 disease...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.04.014
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVES:Older patients with cancer have increased risk for comorbidity, polypharmacy (PP) and drug related problems (DRP). The aim of this study was to assess the effect of a clinical pharmacist and geriatrician medication review (MR) among older outpatients with cancer to optimize management of comorbidities during...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.07.010
更新日期：2021-01-01 00:00:00
abstract：:The authors regret: A calculation error was corrected in Table 3. As mentioned under the table, the percentage of patients under ‘Baseline’ was calculated from the total no. of patients with geriatric recommendations data (n = 932 pts). This was mistakenly calculated from the number of patients with available GA data ...
journal_title：Journal of geriatric oncology
pub_type： 已发布勘误
doi：10.1016/j.jgo.2016.01.005
更新日期：2016-03-01 00:00:00
abstract：OBJECTIVES:No tools accurately discriminate between older patients who are fit and those who are frail to tolerate systemic palliative treatment. This study evaluates whether domains of geriatric assessment (GA) are associated with increased risk of chemotherapy intolerance in patients who were considered fit to start ...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.05.016
更新日期：2020-04-01 00:00:00
abstract：OBJECTIVE:Assess the utility of the G8 screening tool and CGA for older adults with head and neck cancer. METHODS:Patients 65years or older with a primary malignancy of the head and neck region were presented at the multidisciplinary team (MDT) meeting. The Geriatric 8 (G8) questionnaire was administered prior. Clinic...
journal_title：Journal of geriatric oncology
pub_type： 临床试验,杂志文章
doi：10.1016/j.jgo.2016.05.006
更新日期：2016-11-01 00:00:00
abstract：:BACKGROUND: The current study was undertaken to explore whether older age predicts adverse event rates in metastatic melanoma patients participating in cancer clinical trials. METHODS: Six phase II studies conducted at our institution for patients with metastatic disease were used in these pooled analyses: 1) ABT-510...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2012.04.002
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVE:Sarcopenia is associated with poor outcomes in patients undergoing surgery for pancreatic ductal adenocarcinoma (PDAC). However, few studies have assessed changes in sarcopenia during multimodality therapy or its effect on overall survival (OS). METHODS:Computed tomography (CT) total psoas area index (TPAI) ...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2018.03.002
更新日期：2018-07-01 00:00:00
abstract：PURPOSE:Older patients with brain metastases (BM) are often excluded from clinical trials. The aim of our study was to investigate the outcomes following Gamma Knife radiosurgery (GKRS) in young old (65-74 years) and very old (≥75 years) patients with BM. METHODS:Between October 2012 and October 2018, we treated 89 pa...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.03.009
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVE:Suboptimal adherence with endocrine treatment for breast cancer is influenced by a number of factors but remains poorly understood. We sought to describe the prior knowledge about and expectations of breast cancer treatments among older women retrospecting on their diagnosis and treatment. METHODS:Thematic a...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.07.024
更新日期：2020-04-01 00:00:00
abstract：:Multidisciplinary teams (MDTs) have been incorporated into the practical care of elderly patients with cancer. Several geriatric oncology centres have attempted to determine the best way to implement MDTs by using geriatric assessment (GA). Developing a geriatric oncology service is a feasible work, which requires sig...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,评审
doi：10.1016/j.jgo.2016.07.001
更新日期：2016-09-01 00:00:00
