当前位置： SCI文献检索 > Journal of Geriatric Oncology期刊下所有文献 > Association between a cognitive screening test and severe chemotherapy toxicity in older adults with cancer.

Association between a cognitive screening test and severe chemotherapy toxicity in older adults with cancer.

Abstract：

INTRODUCTION:Cognitive impairment (CI) increases chemotherapy toxicity risk with need to understand this association utilizing publicly available short screening tools. We evaluated this utilizing a lower threshold on a short screening tool in older adults with cancer. MATERIALS AND METHODS:We analyzed data from the Cancer and Aging Research Group (CARG) Chemotherapy Toxicity Risk tool (CARG score) development and validation cohorts (n = 703), which recruited adults age ≥ 65 with cancer from academic centers. Cognition was evaluated with the Blessed Orientation-Memory-Concentration test (BOMC). Patients with BOMC score ≥ 11 were excluded. Utilizing cut-points for older adults, we considered moderate BOMC scores (5-10) as potential CI. Logistic regression was used for analysis. RESULTS:Patient baseline characteristics included: mean age 73; 85% white; 63% college or higher education; 250 (36%) potential CI; 385 (55%) severe toxicity. Patients with potential CI were more likely non-white (p ≤ 0.01) and to have high school or lower education (p ≤ 0.01) and high CARG score (p = 0.04). Potential CI was associated with increased severe toxicity risk (OR = 1.54, p ≤ 0.01). After adjusting for CARG score, this association became nonsignificant (OR = 1.35; p = 0.08). Among patients with lower education (n = 258; 36.7%), potential CI remained associated with severe toxicity, even after adjusting for CARG score (OR = 1.87, p = 0.03). CONCLUSIONS:Our findings suggest potential cognitive impairment, defined by BOMC score 5-10, in older adults with cancer and lower education is associated with increased severe toxicity risk. Future studies are needed to validate these findings. Healthcare providers should consider cognitive testing before treatment for these vulnerable patients.

journal_name

J Geriatr Oncol

journal_title

Journal of geriatric oncology

authors

Jayani RV,Magnuson AM,Sun CL,Ma H,Tew WP,Mohile SG,Gajra A,Klepin HD,Gross CP,Muss HB,Chapman AE,Katheria V,Hurria A,Dale W

doi

10.1016/j.jgo.2019.10.004

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

284-289

issue

eissn

1879-4068

issn

1879-4076

pii

S1879-4068(19)30228-0

journal_volume

pub_type

杂志文章

在线工具

Association between a cognitive screening test and severe chemotherapy toxicity in older adults with cancer.