Abstract:
INTRODUCTION:In general, geriatric assessment (GA) provides the combined information on comorbidity and functional, nutritional and psychosocial status and may be predictive for mortality outcome of cancer patients. The impact of geriatric assessment on the outcome of older patients with colorectal cancer treated with chemotherapy is largely unknown. METHODS:In a prospective study, 143 patients with colorectal cancer who were 70years and older were assessed before chemotherapy by Mini Nutritional Assessment (MNA), Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE), Groningen Frailty Indicator (GFI) and Mini Mental State Examination (MMSE). RESULTS:Fifty-four (38%) patients received adjuvant chemotherapy and 89 (62%) patients received palliative chemotherapy. Malnutrition and frailty were prevalent in 39 (27%, assessed by MNA) and 34 (24%, by GFI) patients, respectively; whereas cognitive impairment was prevalent in 19 (13%, by IQCODE) and 11 (8%, by MMSE) patients, respectively. In patients with palliative chemotherapy, poor MNA scores were associated with receiving less than 4cycles of chemotherapy (p=0.008). Poor MNA and GFI scores were associated with increased hazard ratios (HR) for mortality for patients with palliative chemotherapy: HR=2.76 (95% confidence interval [CI]: 1.60-4.77; p<0.001) and HR=2.72 (95% CI: 1.58-4.69; p<0.001), respectively, after adjustment for several clinical parameters. CONCLUSIONS:Malnutrition and frailty were strongly associated with an increased mortality risk in patients who underwent palliative chemotherapy. Furthermore, a poor score on MNA was predictive for less tolerance of chemotherapy. Our findings may help the oncologist in future decision making and advice for elderly patients with colorectal cancer.
journal_name
J Geriatr Oncoljournal_title
Journal of geriatric oncologyauthors
Aaldriks AA,van der Geest LG,Giltay EJ,le Cessie S,Portielje JE,Tanis BC,Nortier JW,Maartense Edoi
10.1016/j.jgo.2013.04.001subject
Has Abstractpub_date
2013-07-01 00:00:00pages
218-26issue
3eissn
1879-4068issn
1879-4076pii
S1879-4068(13)00038-6journal_volume
4pub_type
杂志文章abstract:OBJECTIVE:This study aims to (1) describe the activities, function, and health-related quality of life (HRQOL) of a large sample of older adults (age ≥65) with cancer, (2) identify the associations with demographics, cancer type, comorbid conditions, and ability to participate in activities and functional status. MATE...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2017.02.009
更新日期:2017-07-01 00:00:00
abstract::The aging of the population is a global challenge. The number of older adults is rapidly growing, leading to an increase in the prevalence of noncommunicable diseases associated with aging, such as cancer. Worldwide, older adults account for approximately half of all cancer cases, and this proportion is projected to i...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章,评审
doi:10.1016/j.jgo.2017.06.001
更新日期:2017-09-01 00:00:00
abstract::With a median age of 70 years at diagnosis, lung cancer is a disease of older persons. As a consequence oncologists are confronted with an increasing older lung cancer population for which treatment decisions are needed. In the past years, the therapeutic landscape of advanced non-small cell lung cancer (NSCLC) has ch...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章,评审
doi:10.1016/j.jgo.2018.09.008
更新日期:2019-07-01 00:00:00
abstract:INTRODUCTION:Older adults are underrepresented in landmark trials that determine treatment guidelines for pancreatic cancer. We used the National Cancer Database (NCDB) to compare treatment patterns and outcomes in stage I-III pancreatic cancer between older adult patients, defined as age 80 or older, to patients young...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2019.12.006
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:Elderly patients with cancer are under-represented in clinical trials, and there is especially scant data on their participation in early-phase trials. In an effort to provide more data, we reviewed our Phase I experience. METHODS:We conducted a retrospective analysis of 461 patients enrolled in Phase I clin...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2013.08.005
更新日期:2014-01-01 00:00:00
abstract::Current research efforts focusing on improving outcomes of older adults with cancer lack the appropriate infrastructure to support this growing need. The Cancer and Aging Group R21/33 National Institute of Health (NIH)/National Institute of Aging (NIA) grant aims to support development of geriatric oncology research t...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2019.07.019
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:Older patients with metastatic renal cell carcinoma (mRCC) were underrepresented in pivotal trials. MATERIALS AND METHODS:Consecutive patients with mRCC treated at Aarhus University Hospital with first line tyrosine kinase inhibitors (TKI), mTOR inhibitors, or checkpoint immunotherapy (CPI) were retrospecti...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2020.12.008
更新日期:2020-12-31 00:00:00
abstract:OBJECTIVES:We evaluated the impact of age in a randomized phase II trial that compared three first-line drugs in elderly patients with advanced non-small cell lung cancer (NSCLC) and a poor performance status (PS). MATERIALS AND METHODS:Patients with advanced NSCLC with a PS of 2 or 3 were enrolled into a multicenter ...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.jgo.2015.02.002
更新日期:2015-05-01 00:00:00
abstract:INTRODUCTION:Cognitive impairment (CI) increases chemotherapy toxicity risk with need to understand this association utilizing publicly available short screening tools. We evaluated this utilizing a lower threshold on a short screening tool in older adults with cancer. MATERIALS AND METHODS:We analyzed data from the C...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2019.10.004
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:To assess adjuvant chemotherapy recommendations, administration and disease-specific survival for invasive breast cancer (BC) among patients 75years and older compared with that of younger women. MATERIALS AND METHODS:A cohort of patients with primary breast cancer, aged 65-94, stages I-III from 1990 to 2010...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2012.12.007
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Older patients are at risk for adverse outcomes after surgical treatment of cancer. Identifying patients at risk could affect treatment decisions and prevent functional decline. Screening tools are available to select patients for Geriatric Assessment. Until now their predictive value for adverse outcomes in...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jgo.2017.09.003
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:Older adults frequently experience falls, at great cost to themselves and society. Older adults with cancer may be at greater risk for falls and have unique risk factors. MATERIALS AND METHODS:We undertook a systematic review of the available medical literature to examine the current evidence regarding fact...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章,评审
doi:10.1016/j.jgo.2014.10.003
更新日期:2015-01-01 00:00:00
abstract::Multidisciplinary teams (MDTs) have been incorporated into the practical care of elderly patients with cancer. Several geriatric oncology centres have attempted to determine the best way to implement MDTs by using geriatric assessment (GA). Developing a geriatric oncology service is a feasible work, which requires sig...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章,评审
doi:10.1016/j.jgo.2016.07.001
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:With the aging population, our current understanding of patients with cancer and their family caregivers needs to be expanded to older patients with cancer and their caregivers. By differentiating spousal caregivers and non-spousal caregivers, we aimed to investigate the universalities and particularities of ca...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2019.05.020
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:Older patients with cancer have increased risk for comorbidity, polypharmacy (PP) and drug related problems (DRP). The aim of this study was to assess the effect of a clinical pharmacist and geriatrician medication review (MR) among older outpatients with cancer to optimize management of comorbidities during...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2020.07.010
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Screening tools are used in geriatric oncology to determine who should receive a Comprehensive Geriatric Assessment (CGA). However, in this prospective study, we evaluated the association between geriatric screening results, measured with the G8 and Groningen Frailty Indicator (GFI), and severe treatment tox...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2013.12.004
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:Clinical trials investigating breast cancer treatment often exclude or misrepresent older adults. This study compares treatment patterns and survival of older women diagnosed with breast cancer between a Dutch and a British observational cohort. MATERIALS AND METHODS:Women aged 70 years and older diagnosed w...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2018.05.004
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVES:The global health status of older patients with cancer influences their clinical course, but little is known regarding the influence of the immune system on the global health of older patients with cancer. The goal of this study was to assess the relationships between patient fitness/frailty status and survi...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jgo.2018.03.021
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Geriatric assessment (GA) is an appropriate method for identifying frailty in older patients with cancer, but a shorter instrument may be easier to use in clinical practice. Clinical judgment is always available and requires no investments in time or resources. The purpose of this study was to assess correla...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2020.05.011
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to develop a new brief, comprehensive geriatric assessment scale for older patients diagnosed with different hematological malignancies, the Geriatric Assessment in Hematology (GAH scale), and to determine its psychometric properties. MATERIALS AND METHODS:The 30-item GAH scale...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jgo.2015.03.003
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Cancer in the aging population presents manifold challenges. In the resource-limited settings of developing countries, concrete steps to optimize care for older adults with cancer are required. MATERIALS AND METHOD:This prospective, observational study was divided in two parts. In the first part, older adul...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2020.04.013
更新日期:2021-01-01 00:00:00
abstract:INTRODUCTION:Randomized trials demonstrated oncologic safety and short-term benefits of laparoscopy. We investigated if the benefit of laparoscopy on short-term outcomes is greater for older adults compared with younger adults. METHODS:We identified all older (≥70 years old) and younger (<70) adults with primary sigmo...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2019.09.018
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:An oncogeriatric approach may affect management of elderly patients with breast cancer. However, little is known about oncogeriatric care in the metastatic setting. Therefore, we performed an international comparison of management of elderly patients with primary metastatic disease who were treated in two di...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jgo.2014.02.005
更新日期:2014-07-01 00:00:00
abstract::Data regarding management of frail patients with pancreatic ductal adenocarcinoma practice is currently very scarce. Randomized clinical trials usually exclude these subgroup of patients and the majority of the publications only consider chronological age and ECOG performance status for their classification. Therefore...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章,评审
doi:10.1016/j.jgo.2018.06.005
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVES:Little is known about how psychosocial factors and distress affect older patients with cancer and their survival. The study goals were to: 1) observe the prevalence of anxiety (ANX) and depression (DEP) symptoms at diagnosis in patients aged ≥65 years, 2) observe the association between social isolation (iso...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2020.10.001
更新日期:2020-11-04 00:00:00
abstract::Studies on cancer survival have revealed disparities not only between the elderly and their younger counterparts, but also among the elderly themselves. The aim of this work was to identify sociodemographic, socioeconomic, clinical, and care-related determinants of survival or mortality in older patients with cancer b...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2017.07.007
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:The influence of older age at diagnosis in combination with race/ethnicity on utilization and results of the 21-gene recurrence score (RS) assay for breast cancer (BC) patients is not fully understood. Our objectives were to evaluate the utilization of RS among older women with BC, the likelihood of a high-r...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2020.06.004
更新日期:2020-07-07 00:00:00
abstract:OBJECTIVE:Suboptimal adherence with endocrine treatment for breast cancer is influenced by a number of factors but remains poorly understood. We sought to describe the prior knowledge about and expectations of breast cancer treatments among older women retrospecting on their diagnosis and treatment. METHODS:Thematic a...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2019.07.024
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:This study aims to identify Comprehensive Geriatric Assessment (CGA) based risk factors to help predict caregiver burden among elderly patients with cancer. MATERIALS AND METHOD:The study evaluated 249 patients newly diagnosed with cancer, aged 70years and above, who attended the geriatric oncology clinic at...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2016.03.003
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:The G8 is a screening test to identify frail elderly patients with cancer. Objectives were to design and evaluate the performance of alternative tests taking into account other predictive domains for frailty. METHODS:We conducted a literature review to identify predictive factors of frailty. Using a Delphi c...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2016.01.004
更新日期:2016-03-01 00:00:00