当前位置： SCI文献检索 > Journal of Geriatric Oncology期刊下所有文献 > Treatment of older patients with advanced non-small cell lung cancer: A challenge.

Treatment of older patients with advanced non-small cell lung cancer: A challenge.

Abstract：

:With a median age of 70 years at diagnosis, lung cancer is a disease of older persons. As a consequence oncologists are confronted with an increasing older lung cancer population for which treatment decisions are needed. In the past years, the therapeutic landscape of advanced non-small cell lung cancer (NSCLC) has changed impressively with the introduction of targeted therapies and immunotherapy next to chemotherapy. Treatment choices for advanced NSCLC are mainly guided by different tumor-related characteristics. However, in older patients treatment decisions are more complex because of the scarcity of data from large randomized studies in older patients and the heterogeneity of this population with regards to different geriatric domains such as functional status, comorbidity and polypharmacy. The present manuscript reviews available data for the different treatment options for older patients with NSCLC as well as the use of geriatric assessment as an evaluation and guidance tool.

journal_name

J Geriatr Oncol

journal_title

Journal of geriatric oncology

authors

Decoster L,Schallier D

doi

10.1016/j.jgo.2018.09.008

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

528-533

issue

4

eissn

1879-4068

issn

1879-4076

pii

S1879-4068(18)30110-3

journal_volume

10

pub_type

杂志文章,评审

相关文献

Journal of Geriatric Oncology文献大全
  • Age-related differences in persistence in women with breast cancer treated with tamoxifen or aromatase inhibitors in Germany.

    abstract：AIMS:To study age-related persistence in postmenopausal women with endocrine-responsive breast cancer treated with tamoxifen (TAM) and aromatase inhibitors (AI). METHODS:Data on 29,245 patients diagnosed with metastatic or non-metastatic breast cancer (BC) and initially treated with TAM or AI between 2004 and 2013 wer...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章

    doi：10.1016/j.jgo.2016.03.001

    authors： Jacob L,Hadji P,Kostev K

    更新日期：2016-05-01 00:00:00

  • 21-gene recurrence score testing utilization among older women from different races: A population-based study.

    abstract：OBJECTIVES:The influence of older age at diagnosis in combination with race/ethnicity on utilization and results of the 21-gene recurrence score (RS) assay for breast cancer (BC) patients is not fully understood. Our objectives were to evaluate the utilization of RS among older women with BC, the likelihood of a high-r...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章

    doi：10.1016/j.jgo.2020.06.004

    authors： Gulbahce HE,White S,Herget KA,Stoddard G,Camp NJ,Buys SS,Sweeney C

    更新日期：2020-07-07 00:00:00

  • HER2 status in elderly women with breast cancer.

    abstract：OBJECTIVES:HER2 (human epidermal growth factor receptor 2) is an important biomarker in breast cancer, but its prevalence in elderly women is not well established. Previous studies reported HER2 status based on either immunohistochemistry (IHC) or fluorescent in situ hybridization (FISH) interchangeably. However, the t...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章

    doi：10.1016/j.jgo.2013.05.007

    authors： Laird-Fick HS,Gardiner JC,Tokala H,Patel P,Wei S,Dimitrov NV

    更新日期：2013-10-01 00:00:00

  • Decision-making and cancer screening: a qualitative study of older adults with multiple chronic conditions.

    abstract：OBJECTIVE:To understand how older persons with multiple chronic conditions (MCC) approach decisions about cancer screening. MATERIALS AND METHODS:We conducted interviews with adults >65 years old with at least two chronic conditions who were taking ≥five medications daily. Patients were first asked how age and multimo...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章

    doi：10.1016/j.jgo.2014.12.001

    authors： Gross CP,Fried TR,Tinetti ME,Ross JS,Genao I,Hossain S,Wolf E,Lewis CL

    更新日期：2015-03-01 00:00:00

  • Ofatumumab is safe and effective as front-line treatment in older patients with chronic lymphocytic leukemia and severe co-morbidities, including other malignancies.

    abstract：BACKGROUND:The majority of patients with chronic lymphocytic leukemia (CLL) are older and have multiple comorbidities, including other cancer diagnoses. These patients are routinely excluded from participation in clinical trials. OBJECTIVE:In this phase II study, we determined the activity and toxicity of ofatumumab, ...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章

    doi：10.1016/j.jgo.2019.04.002

    authors： Vitale C,Falchi L,Ciccone M,Burger J,Pemmaraju N,Borthakur G,Wierda WG,Keating MJ,Ferrajoli A

    更新日期：2020-01-01 00:00:00

  • The geriatrician's perspective on practical aspects of the multidisciplinary care of older adults with cancer.

    abstract：:Multidisciplinary teams (MDTs) have been incorporated into the practical care of elderly patients with cancer. Several geriatric oncology centres have attempted to determine the best way to implement MDTs by using geriatric assessment (GA). Developing a geriatric oncology service is a feasible work, which requires sig...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jgo.2016.07.001

    authors： Karnakis T,Gattás-Vernaglia IF,Saraiva MD,Gil-Junior LA,Kanaji AL,Jacob-Filho W

    更新日期：2016-09-01 00:00:00

  • Impact of geriatric assessment on the management of older adults with head and neck cancer: A pilot study.

    abstract：OBJECTIVE:Assess the utility of the G8 screening tool and CGA for older adults with head and neck cancer. METHODS:Patients 65years or older with a primary malignancy of the head and neck region were presented at the multidisciplinary team (MDT) meeting. The Geriatric 8 (G8) questionnaire was administered prior. Clinic...

    journal_title：Journal of geriatric oncology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jgo.2016.05.006

    authors： Neve M,Jameson MB,Govender S,Hartopeanu C

    更新日期：2016-11-01 00:00:00

  • Impact of a pharmacist and geriatrician medication review on drug-related problems in older outpatients with cancer.

    abstract：OBJECTIVES:Older patients with cancer have increased risk for comorbidity, polypharmacy (PP) and drug related problems (DRP). The aim of this study was to assess the effect of a clinical pharmacist and geriatrician medication review (MR) among older outpatients with cancer to optimize management of comorbidities during...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章

    doi：10.1016/j.jgo.2020.07.010

    authors： Choukroun C,Leguelinel-Blache G,Roux-Marson C,Jamet C,Martin-Allier A,Kinowski JM,Le Guillou C,Richard H,Antoine V

    更新日期：2021-01-01 00:00:00

  • Survival benefit of statins in older patients with rectal cancer: A Swedish population-based cohort study.

    abstract：OBJECTIVES:Increasing evidence suggests that statins may have antitumor effects but their role in rectal cancer appears inconclusive. The aim of this study was to investigate whether statins may have an impact on survival of older and younger patients with rectal cancer. MATERIALS AND METHODS:This study included 238 p...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章

    doi：10.1016/j.jgo.2019.01.011

    authors： Kotti A,Holmqvist A,Albertsson M,Sun XF

    更新日期：2019-09-01 00:00:00

  • Similar survival rates with first-line gefitinib, gemcitabine, or docetaxel in a randomized phase II trial in elderly patients with advanced non-small cell lung cancer and a poor performance status (IFCT-0301).

    abstract：OBJECTIVES:We evaluated the impact of age in a randomized phase II trial that compared three first-line drugs in elderly patients with advanced non-small cell lung cancer (NSCLC) and a poor performance status (PS). MATERIALS AND METHODS:Patients with advanced NSCLC with a PS of 2 or 3 were enrolled into a multicenter ...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jgo.2015.02.002

    authors： Des Guetz G,Landre T,Westeel V,Milleron B,Vaylet F,Urban T,Barlesi F,Souquet PJ,Debieuvre D,Braun D,Fraboulet G,Monnet I,Uzzan B,Molinier O,Morin F,Moro-Sibilot D,Morère JF

    更新日期：2015-05-01 00:00:00

  • Outcome and prognostic factors for older patients undergoing radiosurgery for brain metastases.

    abstract：PURPOSE:Older patients with brain metastases (BM) are often excluded from clinical trials. The aim of our study was to investigate the outcomes following Gamma Knife radiosurgery (GKRS) in young old (65-74 years) and very old (≥75 years) patients with BM. METHODS:Between October 2012 and October 2018, we treated 89 pa...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章

    doi：10.1016/j.jgo.2020.03.009

    authors： Desideri I,Becherini C,Visani L,Stocchi G,Scoccimarro E,Mariotti M,Salvestrini V,Scoccianti S,Greto D,Bonomo P,Pecchioli G,Bordi L,Della Puppa A,Francolini G,Meattini I,Livi L

    更新日期：2020-09-01 00:00:00

  • Patient Characteristics Associated with Polypharmacy and Inappropriate Prescribing of Medications among Older Adults with Cancer.

    abstract：:OBJECTIVES: To identify patient characteristics associated with polypharmacy and inappropriate medication (PIM) use among older patients with newly diagnosed cancer. DESIGN: Cross-Sectional Study. SETTING: Ambulatory oncology clinics at an academic medical center. PARTICIPANTS: 117 patients aged ≥ 65 years with new...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章

    doi：10.1016/j.jgo.2012.02.005

    authors： Prithviraj GK,Koroukian S,Margevicius S,Berger NA,Bagai R,Owusu C

    更新日期：2012-07-01 00:00:00

  • An evaluation of elderly patients (≥70 years old) enrolled in Phase I clinical trials at University of Texas Health Science Center at San Antonio-Cancer Therapy Research Center from 2009 to 2011.

    abstract：OBJECTIVE:Elderly patients with cancer are under-represented in clinical trials, and there is especially scant data on their participation in early-phase trials. In an effort to provide more data, we reviewed our Phase I experience. METHODS:We conducted a retrospective analysis of 461 patients enrolled in Phase I clin...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章

    doi：10.1016/j.jgo.2013.08.005

    authors： Rowe J,Patel S,Mazo-Canola M,Parra A,Goros M,Michalek J,Kelly K,Weitman S,Karnad A

    更新日期：2014-01-01 00:00:00

  • Patient-reported psychosocial needs and psychological distress predict survival in geriatric oncology patients.

    abstract：OBJECTIVES:Little is known about how psychosocial factors and distress affect older patients with cancer and their survival. The study goals were to: 1) observe the prevalence of anxiety (ANX) and depression (DEP) symptoms at diagnosis in patients aged ≥65 years, 2) observe the association between social isolation (iso...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章

    doi：10.1016/j.jgo.2020.10.001

    authors： Leung B,Shokoohi A,Bates A,Ho C

    更新日期：2020-11-04 00:00:00

  • Development and psychometric validation of a brief comprehensive health status assessment scale in older patients with hematological malignancies: The GAH Scale.

    abstract：OBJECTIVES:The purpose of this study was to develop a new brief, comprehensive geriatric assessment scale for older patients diagnosed with different hematological malignancies, the Geriatric Assessment in Hematology (GAH scale), and to determine its psychometric properties. MATERIALS AND METHODS:The 30-item GAH scale...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jgo.2015.03.003

    authors： Bonanad S,De la Rubia J,Gironella M,Pérez Persona E,González B,Fernández Lago C,Arnan M,Zudaire M,Hernández Rivas JA,Soler A,Marrero C,Olivier C,Altés A,Valcárcel D,Hernández MT,Oiartzabal I,Fernández Ordoño R,Arnao M,

    更新日期：2015-09-01 00:00:00

  • Is Age ≥ 70 Years an Important Predictor of Adverse Events Among Patients Enrolled in Metastatic Melanoma Trials? Findings from Pooled Analyses of Therapeutic Trials.

    abstract：:BACKGROUND: The current study was undertaken to explore whether older age predicts adverse event rates in metastatic melanoma patients participating in cancer clinical trials. METHODS: Six phase II studies conducted at our institution for patients with metastatic disease were used in these pooled analyses: 1) ABT-510...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章

    doi：10.1016/j.jgo.2012.04.002

    authors： Jatoi A,Allred JB,Suman VJ,Creagan ET,Croghan GA,Amatruda T,Markovic SN

    更新日期：2012-10-01 00:00:00

  • Sociodemographic, socioeconomic, and clinical determinants of survival in patients with cancer: A systematic review of the literature focused on the elderly.

    abstract：:Studies on cancer survival have revealed disparities not only between the elderly and their younger counterparts, but also among the elderly themselves. The aim of this work was to identify sociodemographic, socioeconomic, clinical, and care-related determinants of survival or mortality in older patients with cancer b...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章

    doi：10.1016/j.jgo.2017.07.007

    authors： Galvin A,Delva F,Helmer C,Rainfray M,Bellera C,Rondeau V,Soubeyran P,Coureau G,Mathoulin-Pélissier S

    更新日期：2018-01-01 00:00:00

  • Risk stratification for surgical outcomes in older colorectal cancer patients using ISAR-HP and G8 screening tools.

    abstract：BACKGROUND:Older patients are at risk for adverse outcomes after surgical treatment of cancer. Identifying patients at risk could affect treatment decisions and prevent functional decline. Screening tools are available to select patients for Geriatric Assessment. Until now their predictive value for adverse outcomes in...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jgo.2017.09.003

    authors： Souwer ETD,Verweij NM,van den Bos F,Bastiaannet E,Slangen RME,Steup WH,Hamaker ME,Portielje JEA

    更新日期：2018-03-01 00:00:00

  • Low levels of intra-tumoural T cells in breast cancer identify clinically frail patients with shorter disease-specific survival.

    abstract：OBJECTIVES:The global health status of older patients with cancer influences their clinical course, but little is known regarding the influence of the immune system on the global health of older patients with cancer. The goal of this study was to assess the relationships between patient fitness/frailty status and survi...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jgo.2018.03.021

    authors： Speigl L,Grieb A,Janssen N,Hatse S,Brouwers B,Smeets A,Floris G,Bailur JK,Kenis C,Neven P,Wildiers H,Pawelec G,Shipp C

    更新日期：2018-11-01 00:00:00

  • Management of primary metastatic breast cancer in elderly patients--an international comparison of oncogeriatric versus standard care.

    abstract：BACKGROUND:An oncogeriatric approach may affect management of elderly patients with breast cancer. However, little is known about oncogeriatric care in the metastatic setting. Therefore, we performed an international comparison of management of elderly patients with primary metastatic disease who were treated in two di...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jgo.2014.02.005

    authors： van de Water W,Bastiaannet E,Egan KM,de Craen AJ,Westendorp RG,Balducci L,van de Velde CJ,Liefers GJ,Extermann M

    更新日期：2014-07-01 00:00:00

  • Moving beyond symptom management towards cancer rehabilitation for older adults: Answering the 5W's.

    abstract：:Older adults with cancer are quickly becoming the largest group of cancer survivors. Chronological age is a poor predictor of cancer treatment outcomes and of the need for rehabilitation services. While newer symptom management systems and assessments are slowly becoming used in the clinic to improve communication bet...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jgo.2017.11.009

    authors： Pergolotti M,Lyons KD,Williams GR

    更新日期：2018-11-01 00:00:00

  • Detection of frailty in elderly cancer patients: Improvement of the G8 screening test.

    abstract：OBJECTIVE:The G8 is a screening test to identify frail elderly patients with cancer. Objectives were to design and evaluate the performance of alternative tests taking into account other predictive domains for frailty. METHODS:We conducted a literature review to identify predictive factors of frailty. Using a Delphi c...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章

    doi：10.1016/j.jgo.2016.01.004

    authors： Petit-Monéger A,Rainfray M,Soubeyran P,Bellera CA,Mathoulin-Pélissier S

    更新日期：2016-03-01 00:00:00

  • Implementing and validating a care protocol for older adults with cancer in resource limited settings with a newly developed screening tool.

    abstract：BACKGROUND:Cancer in the aging population presents manifold challenges. In the resource-limited settings of developing countries, concrete steps to optimize care for older adults with cancer are required. MATERIALS AND METHOD:This prospective, observational study was divided in two parts. In the first part, older adul...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章

    doi：10.1016/j.jgo.2020.04.013

    authors： Banerjee J,Behal P,Satapathy S,Kandel R,Upadhyay AD,Dwivedi S,Kumar L,Dey AB

    更新日期：2021-01-01 00:00:00

  • Omission of axillary staging in elderly patients with early stage breast cancer impacts regional control but not survival: A systematic review and meta-analysis.

    abstract：INTRODUCTION:Management of early breast cancer in the elderly population is challenging due to different breast cancer biology and limited tolerance to aggressive treatments. The aim of this study is to evaluate whether the omission of axillary staging impacts breast cancer outcomes in elderly patients. PATIENTS AND M...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.jgo.2016.12.003

    authors： Liang S,Hallet J,Simpson JS,Tricco AC,Scheer AS

    更新日期：2017-03-01 00:00:00

  • Optimal management of localized rectal cancer in older patients.

    abstract：:In advising the optimal management for older patients, health care professionals try to balance the risks from frailty, vulnerability, and comorbidity against the patient's ultimate prognosis, potential functional outcomes and quality of life (QOL). At the same time it is important to involve the patient and incorpora...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jgo.2018.08.001

    authors： Bujko K,Glynne-Jones R,Papamichael D,Rutten HJT

    更新日期：2018-11-01 00:00:00

  • Potential drug-drug interactions and risk of unplanned hospitalization in older patients with cancer: A survey of the prospective ELCAPA (ELderly CAncer PAtients) cohort.

    abstract：BACKGROUND:Because of comorbidities and polypharmacy, older patients with cancer have a greater risk of iatrogenic events. We aimed to characterize potential drug-drug interactions (PDIs) and the risk of unplanned hospitalization in older patients with cancer treated with antineoplastic agents (ANAs). METHODS:We analy...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章

    doi：10.1016/j.jgo.2019.07.023

    authors： Beinse G,Reitter D,Segaux L,Carvahlo-Verlinde M,Rousseau B,Tournigand C,Cudennec T,Laurent M,Boudou-Rouquette P,Paillaud E,Canouï-Poitrine F,Caillet P,ELCAPA Study Group.

    更新日期：2020-05-01 00:00:00

  • Global geriatric oncology: Achievements and challenges.

    abstract：:The aging of the population is a global challenge. The number of older adults is rapidly growing, leading to an increase in the prevalence of noncommunicable diseases associated with aging, such as cancer. Worldwide, older adults account for approximately half of all cancer cases, and this proportion is projected to i...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jgo.2017.06.001

    authors： Soto-Perez-de-Celis E,de Glas NA,Hsu T,Kanesvaran R,Steer C,Navarrete-Reyes AP,Battisti NML,Chavarri-Guerra Y,O'Donovan A,Avila-Funes JA,Hurria A

    更新日期：2017-09-01 00:00:00

  • Single-arm phase II trial to evaluate efficacy and tolerance of regorafenib monotherapy in patients over 70 with previously treated metastatic colorectal adenocarcinoma FFCD 1404 - REGOLD.

    abstract：BACKGROUND:Regorafenib significantly increases overall survival (OS) in patients with metastatic colorectal cancer previously treated but gives toxicities. OBJECTIVES:to assess the efficacy and safety of regorafenib at it's approved dose in the older population. PATIENTS AND METHODS:This multicenter single-arm phase ...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章

    doi：10.1016/j.jgo.2020.04.001

    authors： Aparicio T,Darut-Jouve A,Khemissa Akouz F,Montérymard C,Artru P,Cany L,Romano O,Valenza B,Le Foll C,Delbaldo C,Falandry C,Norguet Monnereau E,Ben Abdelghani M,Smith D,Rinaldi Y,Père Verge D,Baize N,Maillard E,Dohan A

    更新日期：2020-11-01 00:00:00

  • Impact of age on treatment trends and clinical outcome in patients with metastatic renal cell carcinoma.

    abstract：OBJECTIVES:Clinical outcomes in older adults with metastatic renal cell carcinoma (mRCC) are poorly understood, particularly in the era of targeted therapies. We characterize survival and relevant treatment-related variables in a modern series. MATERIALS AND METHODS:From an institutional database including 562 patient...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章

    doi：10.1016/j.jgo.2012.11.001

    authors： Pal SK,Hsu J,Hsu S,Hu J,Bergerot P,Carmichael C,Saikia J,Liu X,Lau C,Twardowski P,Figlin RA,Yuh BF

    更新日期：2013-04-01 00:00:00

  • Activities, function, and health-related quality of life (HRQOL) of older adults with cancer.

    abstract：OBJECTIVE:This study aims to (1) describe the activities, function, and health-related quality of life (HRQOL) of a large sample of older adults (age ≥65) with cancer, (2) identify the associations with demographics, cancer type, comorbid conditions, and ability to participate in activities and functional status. MATE...

    journal_title：Journal of geriatric oncology

    pub_type： 杂志文章

    doi：10.1016/j.jgo.2017.02.009

    authors： Pergolotti M,Deal AM,Williams GR,Bryant AL,Bensen JT,Muss HB,Reeve BB

    更新日期：2017-07-01 00:00:00