Abstract：
PURPOSE:Older patients with brain metastases (BM) are often excluded from clinical trials. The aim of our study was to investigate the outcomes following Gamma Knife radiosurgery (GKRS) in young old (65-74 years) and very old (≥75 years) patients with BM. METHODS:Between October 2012 and October 2018, we treated 89 patients aged ≥65 years with GKRS. Patients were divided in two group: young old (YO) and very old (VO) patients. At baseline G8, Graded Prognostic Assessment (DS-GPA) and Basic Score for Brain Metastases (BSBM) were assessed for all patients. Survival analysis was estimated using the Kaplan-Meier (KM) method. Cox regression model was used to investigate the influence of significant factors on KM. RESULTS:Median age at the time of GKRS was 72.2 years (range 65-87). A mean of 2.52 lesions were treated per patient (range 1-14). Median overall survival (OS) for YO and VO patients was 14.2 and 15.7 months, respectively. At univariate analysis, there were no significant differences in OS between the two age groups. A high BSBM (p ≤ .0001) and a high DS-GPA score (p = .0069) were associated with longer survival. A low DS-GPA score was the most powerful independent factor for predicting short survival (HR 1.76, 95% CI 1.25-2.46, p = .001) at multivariate analysis. CONCLUSION:GKRS is a safe approach to treat BM in elderly patients. DS-GPA score represents an important prognostic factor for survival in elderly patients undergoing GKRS.
journal_name
J Geriatr Oncoljournal_title
Journal of geriatric oncologyauthors
Desideri I,Becherini C,Visani L,Stocchi G,Scoccimarro E,Mariotti M,Salvestrini V,Scoccianti S,Greto D,Bonomo P,Pecchioli G,Bordi L,Della Puppa A,Francolini G,Meattini I,Livi Ldoi
10.1016/j.jgo.2020.03.009subject
Has Abstractpub_date
2020-09-01 00:00:00pages
1103-1107issue
7eissn
1879-4068issn
1879-4076pii
S1879-4068(19)31650-9journal_volume
11pub_type
杂志文章abstract：:OBJECTIVES: To identify patient characteristics associated with polypharmacy and inappropriate medication (PIM) use among older patients with newly diagnosed cancer. DESIGN: Cross-Sectional Study. SETTING: Ambulatory oncology clinics at an academic medical center. PARTICIPANTS: 117 patients aged ≥ 65 years with new...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2012.02.005
更新日期：2012-07-01 00:00:00
abstract：INTRODUCTION:Cognitive impairment (CI) increases chemotherapy toxicity risk with need to understand this association utilizing publicly available short screening tools. We evaluated this utilizing a lower threshold on a short screening tool in older adults with cancer. MATERIALS AND METHODS:We analyzed data from the C...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.10.004
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVE:The G8 is a screening test to identify frail elderly patients with cancer. Objectives were to design and evaluate the performance of alternative tests taking into account other predictive domains for frailty. METHODS:We conducted a literature review to identify predictive factors of frailty. Using a Delphi c...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2016.01.004
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Screening tools are used in geriatric oncology to determine who should receive a Comprehensive Geriatric Assessment (CGA). However, in this prospective study, we evaluated the association between geriatric screening results, measured with the G8 and Groningen Frailty Indicator (GFI), and severe treatment tox...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2013.12.004
更新日期：2014-04-01 00:00:00
abstract：:Studies on cancer survival have revealed disparities not only between the elderly and their younger counterparts, but also among the elderly themselves. The aim of this work was to identify sociodemographic, socioeconomic, clinical, and care-related determinants of survival or mortality in older patients with cancer b...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2017.07.007
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:This study aims to (1) describe the activities, function, and health-related quality of life (HRQOL) of a large sample of older adults (age ≥65) with cancer, (2) identify the associations with demographics, cancer type, comorbid conditions, and ability to participate in activities and functional status. MATE...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2017.02.009
更新日期：2017-07-01 00:00:00
abstract：INTRODUCTION:Randomized trials demonstrated oncologic safety and short-term benefits of laparoscopy. We investigated if the benefit of laparoscopy on short-term outcomes is greater for older adults compared with younger adults. METHODS:We identified all older (≥70 years old) and younger (<70) adults with primary sigmo...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.09.018
更新日期：2020-06-01 00:00:00
abstract：:Data regarding management of frail patients with pancreatic ductal adenocarcinoma practice is currently very scarce. Randomized clinical trials usually exclude these subgroup of patients and the majority of the publications only consider chronological age and ECOG performance status for their classification. Therefore...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,评审
doi：10.1016/j.jgo.2018.06.005
更新日期：2019-05-01 00:00:00
abstract：OBJECTIVES:This study aims to investigate the use of chemotherapy with or without bevacizumab in older patients with metastatic colorectal cancer (mCRC) in current daily practice and to identify predictive parameters for treatment-related outcomes. PATIENTS AND METHODS:This is a Belgian multi-centre, observational coh...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jgo.2017.10.002
更新日期：2018-03-01 00:00:00
abstract：BACKGROUND:Because of comorbidities and polypharmacy, older patients with cancer have a greater risk of iatrogenic events. We aimed to characterize potential drug-drug interactions (PDIs) and the risk of unplanned hospitalization in older patients with cancer treated with antineoplastic agents (ANAs). METHODS:We analy...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.07.023
更新日期：2020-05-01 00:00:00
abstract：:It is well recognized that the incidence of breast cancer increases significantly with age. Despite this, older people remain under-represented in many clinical trials and their management relies on extrapolation of data from younger patients. Providing an aggressive intervention can be challenging, particularly in le...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,评审
doi：10.1016/j.jgo.2017.05.004
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:An oncogeriatric approach may affect management of elderly patients with breast cancer. However, little is known about oncogeriatric care in the metastatic setting. Therefore, we performed an international comparison of management of elderly patients with primary metastatic disease who were treated in two di...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jgo.2014.02.005
更新日期：2014-07-01 00:00:00
abstract：:Adjuvant chemotherapy improves overall survival (OS) following stereotactic body radiotherapy (SBRT) in patients with early stage non-small cell lung cancer and tumors ≥four cm. Here, we aim to evaluate its role following SBRT in older patients. Patients >70 years diagnosed with clinical stages I-II NSCLC, (N0 disease...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.04.014
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVES:The purpose of this study was to develop a new brief, comprehensive geriatric assessment scale for older patients diagnosed with different hematological malignancies, the Geriatric Assessment in Hematology (GAH scale), and to determine its psychometric properties. MATERIALS AND METHODS:The 30-item GAH scale...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jgo.2015.03.003
更新日期：2015-09-01 00:00:00
abstract：OBJECTIVES:The global health status of older patients with cancer influences their clinical course, but little is known regarding the influence of the immune system on the global health of older patients with cancer. The goal of this study was to assess the relationships between patient fitness/frailty status and survi...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jgo.2018.03.021
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:A geriatric assessment (GA) is increasingly used to help guide treatment decisions in older patients with cancer. However, there is no consensus regarding which domains should be included in the GA. In addition, the field of geriatric oncology moves very fast and as a result many new studies have been publis...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.02.010
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND:Older patients are at risk for adverse outcomes after surgical treatment of cancer. Identifying patients at risk could affect treatment decisions and prevent functional decline. Screening tools are available to select patients for Geriatric Assessment. Until now their predictive value for adverse outcomes in...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jgo.2017.09.003
更新日期：2018-03-01 00:00:00
abstract：INTRODUCTION:Management of early breast cancer in the elderly population is challenging due to different breast cancer biology and limited tolerance to aggressive treatments. The aim of this study is to evaluate whether the omission of axillary staging impacts breast cancer outcomes in elderly patients. PATIENTS AND M...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jgo.2016.12.003
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVES:To investigate changes in inflammatory biomarkers during induction therapy for older adults with acute myeloid leukemia (AML) and their associations with geriatric assessment (GA) measures and outcomes. METHODS:This was a single institution ancillary study to a prospective observational study (N = 20 consec...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.03.014
更新日期：2020-04-01 00:00:00
abstract：INTRODUCTION:Older adults are underrepresented in landmark trials that determine treatment guidelines for pancreatic cancer. We used the National Cancer Database (NCDB) to compare treatment patterns and outcomes in stage I-III pancreatic cancer between older adult patients, defined as age 80 or older, to patients young...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.12.006
更新日期：2020-05-01 00:00:00
abstract：AIMS:To study age-related persistence in postmenopausal women with endocrine-responsive breast cancer treated with tamoxifen (TAM) and aromatase inhibitors (AI). METHODS:Data on 29,245 patients diagnosed with metastatic or non-metastatic breast cancer (BC) and initially treated with TAM or AI between 2004 and 2013 wer...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2016.03.001
更新日期：2016-05-01 00:00:00
abstract：OBJECTIVE:To date, most comorbidity studies have analyzed either a subgroup of frequent diseases, or used summary instruments such as the Charlson score or the Cumulative Illness Rating Scale-Geriatric (CIRS-G). Yet, comorbidity is a multidimensional construct and impacts function, treatment tolerance, and survival. We...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2017.07.005
更新日期：2017-09-01 00:00:00
abstract：OBJECTIVES:HER2 (human epidermal growth factor receptor 2) is an important biomarker in breast cancer, but its prevalence in elderly women is not well established. Previous studies reported HER2 status based on either immunohistochemistry (IHC) or fluorescent in situ hybridization (FISH) interchangeably. However, the t...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2013.05.007
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVE:Suboptimal adherence with endocrine treatment for breast cancer is influenced by a number of factors but remains poorly understood. We sought to describe the prior knowledge about and expectations of breast cancer treatments among older women retrospecting on their diagnosis and treatment. METHODS:Thematic a...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.07.024
更新日期：2020-04-01 00:00:00
abstract：:The "Cadillac Study" was the term Arti Hurria, MD often used to articulate her vision of the optimal study to investigate the effects of cancer and its treatments on aging trajectories. In her opinion, this study needed to be designed for near-term clinical translation and have the ability to discern subpopulations of...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.06.009
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVE:To assess adjuvant chemotherapy recommendations, administration and disease-specific survival for invasive breast cancer (BC) among patients 75years and older compared with that of younger women. MATERIALS AND METHODS:A cohort of patients with primary breast cancer, aged 65-94, stages I-III from 1990 to 2010...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2012.12.007
更新日期：2013-04-01 00:00:00
abstract：OBJECTIVES:The influence of older age at diagnosis in combination with race/ethnicity on utilization and results of the 21-gene recurrence score (RS) assay for breast cancer (BC) patients is not fully understood. Our objectives were to evaluate the utilization of RS among older women with BC, the likelihood of a high-r...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.06.004
更新日期：2020-07-07 00:00:00
abstract：OBJECTIVE:To understand how older persons with multiple chronic conditions (MCC) approach decisions about cancer screening. MATERIALS AND METHODS:We conducted interviews with adults >65 years old with at least two chronic conditions who were taking ≥five medications daily. Patients were first asked how age and multimo...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2014.12.001
更新日期：2015-03-01 00:00:00
abstract：OBJECTIVE:Sarcopenia is associated with poor outcomes in patients undergoing surgery for pancreatic ductal adenocarcinoma (PDAC). However, few studies have assessed changes in sarcopenia during multimodality therapy or its effect on overall survival (OS). METHODS:Computed tomography (CT) total psoas area index (TPAI) ...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2018.03.002
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Regorafenib significantly increases overall survival (OS) in patients with metastatic colorectal cancer previously treated but gives toxicities. OBJECTIVES:to assess the efficacy and safety of regorafenib at it's approved dose in the older population. PATIENTS AND METHODS:This multicenter single-arm phase ...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.04.001
更新日期：2020-11-01 00:00:00
