Abstract：
:It is well recognized that the incidence of breast cancer increases significantly with age. Despite this, older people remain under-represented in many clinical trials and their management relies on extrapolation of data from younger patients. Providing an aggressive intervention can be challenging, particularly in less fit older patients where a conservative approach is commonly perceived to be more appropriate. The optimal management of this population is unknown and treatment decision should be personalized. This review article will discuss several controversial issues in managing older adults with early breast cancer in a multidisciplinary setting, including the role of surgical treatment of the axilla in clinically node negative disease, radiotherapy after breast conservation surgery in low-risk tumours, personalizing adjuvant systemic therapy, and geriatric assessments in breast cancer treatment decisions.
journal_name
J Geriatr Oncoljournal_title
Journal of geriatric oncologyauthors
Mislang AR,Cheung KL,Hamaker ME,Kunkler I,Markopoulos C,Orecchia R,Brain E,Biganzoli Ldoi
10.1016/j.jgo.2017.05.004subject
Has Abstractpub_date
2017-11-01 00:00:00pages
397-402issue
6eissn
1879-4068issn
1879-4076pii
S1879-4068(17)30097-8journal_volume
8pub_type
杂志文章,评审abstract：BACKGROUND:Older patients are at risk for adverse outcomes after surgical treatment of cancer. Identifying patients at risk could affect treatment decisions and prevent functional decline. Screening tools are available to select patients for Geriatric Assessment. Until now their predictive value for adverse outcomes in...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jgo.2017.09.003
更新日期：2018-03-01 00:00:00
abstract：BACKGROUND:Metastasectomy has a curative potential in colon cancer, but its benefits have not been ascertained in population data. Our objective was to evaluate utilization of metastasectomy in colon cancer and its survival outcomes in groups defined by different age at diagnosis, tumor grade or varying extent of nodal...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2015.08.002
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVE:Sarcopenia is associated with poor outcomes in patients undergoing surgery for pancreatic ductal adenocarcinoma (PDAC). However, few studies have assessed changes in sarcopenia during multimodality therapy or its effect on overall survival (OS). METHODS:Computed tomography (CT) total psoas area index (TPAI) ...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2018.03.002
更新日期：2018-07-01 00:00:00
abstract：OBJECTIVE:The G8 is a screening test to identify frail elderly patients with cancer. Objectives were to design and evaluate the performance of alternative tests taking into account other predictive domains for frailty. METHODS:We conducted a literature review to identify predictive factors of frailty. Using a Delphi c...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2016.01.004
更新日期：2016-03-01 00:00:00
abstract：OBJECTIVES:Older patients with metastatic renal cell carcinoma (mRCC) were underrepresented in pivotal trials. MATERIALS AND METHODS:Consecutive patients with mRCC treated at Aarhus University Hospital with first line tyrosine kinase inhibitors (TKI), mTOR inhibitors, or checkpoint immunotherapy (CPI) were retrospecti...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.12.008
更新日期：2020-12-31 00:00:00
abstract：:Current research efforts focusing on improving outcomes of older adults with cancer lack the appropriate infrastructure to support this growing need. The Cancer and Aging Group R21/33 National Institute of Health (NIH)/National Institute of Aging (NIA) grant aims to support development of geriatric oncology research t...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.07.019
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:Regorafenib significantly increases overall survival (OS) in patients with metastatic colorectal cancer previously treated but gives toxicities. OBJECTIVES:to assess the efficacy and safety of regorafenib at it's approved dose in the older population. PATIENTS AND METHODS:This multicenter single-arm phase ...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.04.001
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVES:This study aims to investigate the use of chemotherapy with or without bevacizumab in older patients with metastatic colorectal cancer (mCRC) in current daily practice and to identify predictive parameters for treatment-related outcomes. PATIENTS AND METHODS:This is a Belgian multi-centre, observational coh...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jgo.2017.10.002
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVE:Assess the utility of the G8 screening tool and CGA for older adults with head and neck cancer. METHODS:Patients 65years or older with a primary malignancy of the head and neck region were presented at the multidisciplinary team (MDT) meeting. The Geriatric 8 (G8) questionnaire was administered prior. Clinic...
journal_title：Journal of geriatric oncology
pub_type： 临床试验,杂志文章
doi：10.1016/j.jgo.2016.05.006
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:Geriatric assessment (GA) is an appropriate method for identifying frailty in older patients with cancer, but a shorter instrument may be easier to use in clinical practice. Clinical judgment is always available and requires no investments in time or resources. The purpose of this study was to assess correla...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.05.011
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVES:No tools accurately discriminate between older patients who are fit and those who are frail to tolerate systemic palliative treatment. This study evaluates whether domains of geriatric assessment (GA) are associated with increased risk of chemotherapy intolerance in patients who were considered fit to start ...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.05.016
更新日期：2020-04-01 00:00:00
abstract：:Sexual health and sexual minority status are often undiscussed during oncology visits. Yet, these topics should be addressed in older cancer patients in order to help mitigate the sexual side effects of cancer treatment and to acknowledge - and, at times, help provide - the social support older patients need during th...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,评审
doi：10.1016/j.jgo.2019.08.003
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVE:Suboptimal adherence with endocrine treatment for breast cancer is influenced by a number of factors but remains poorly understood. We sought to describe the prior knowledge about and expectations of breast cancer treatments among older women retrospecting on their diagnosis and treatment. METHODS:Thematic a...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.07.024
更新日期：2020-04-01 00:00:00
abstract：OBJECTIVES:The influence of older age at diagnosis in combination with race/ethnicity on utilization and results of the 21-gene recurrence score (RS) assay for breast cancer (BC) patients is not fully understood. Our objectives were to evaluate the utilization of RS among older women with BC, the likelihood of a high-r...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.06.004
更新日期：2020-07-07 00:00:00
abstract：OBJECTIVES:Little is known about how psychosocial factors and distress affect older patients with cancer and their survival. The study goals were to: 1) observe the prevalence of anxiety (ANX) and depression (DEP) symptoms at diagnosis in patients aged ≥65 years, 2) observe the association between social isolation (iso...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.10.001
更新日期：2020-11-04 00:00:00
abstract：OBJECTIVE:Elderly patients with cancer are under-represented in clinical trials, and there is especially scant data on their participation in early-phase trials. In an effort to provide more data, we reviewed our Phase I experience. METHODS:We conducted a retrospective analysis of 461 patients enrolled in Phase I clin...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2013.08.005
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Cancer in the aging population presents manifold challenges. In the resource-limited settings of developing countries, concrete steps to optimize care for older adults with cancer are required. MATERIALS AND METHOD:This prospective, observational study was divided in two parts. In the first part, older adul...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.04.013
更新日期：2021-01-01 00:00:00
abstract：:Older adults with cancer are quickly becoming the largest group of cancer survivors. Chronological age is a poor predictor of cancer treatment outcomes and of the need for rehabilitation services. While newer symptom management systems and assessments are slowly becoming used in the clinic to improve communication bet...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,评审
doi：10.1016/j.jgo.2017.11.009
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVES:Older patients with cancer have increased risk for comorbidity, polypharmacy (PP) and drug related problems (DRP). The aim of this study was to assess the effect of a clinical pharmacist and geriatrician medication review (MR) among older outpatients with cancer to optimize management of comorbidities during...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.07.010
更新日期：2021-01-01 00:00:00
abstract：:Older cancer survivors may experience ageing at an accelerated rate when compared to their similar-aged, cancer-free counterparts. Ageing is undoubtedly a significant risk factor for cancer. There is evidence to suggest, however, that this relationship may in fact be bidirectional, with cancer and its treatments contr...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,评审
doi：10.1016/j.jgo.2020.09.010
更新日期：2020-09-12 00:00:00
abstract：BACKGROUND:Because of comorbidities and polypharmacy, older patients with cancer have a greater risk of iatrogenic events. We aimed to characterize potential drug-drug interactions (PDIs) and the risk of unplanned hospitalization in older patients with cancer treated with antineoplastic agents (ANAs). METHODS:We analy...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.07.023
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVE:To assess adjuvant chemotherapy recommendations, administration and disease-specific survival for invasive breast cancer (BC) among patients 75years and older compared with that of younger women. MATERIALS AND METHODS:A cohort of patients with primary breast cancer, aged 65-94, stages I-III from 1990 to 2010...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2012.12.007
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:Adjuvant! Online is a tool used for clinical decision making in patients with early stage colon cancer. As details of the tool's construction are not published, the ability of Adjuvant! Online to accurately predict outcomes for older patients (age 70+) with node positive colon cancer receiving adjuvant chemo...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2016.07.002
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:A geriatric assessment (GA) is increasingly used to help guide treatment decisions in older patients with cancer. However, there is no consensus regarding which domains should be included in the GA. In addition, the field of geriatric oncology moves very fast and as a result many new studies have been publis...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.02.010
更新日期：2019-11-01 00:00:00
abstract：OBJECTIVES:Increasing evidence suggests that statins may have antitumor effects but their role in rectal cancer appears inconclusive. The aim of this study was to investigate whether statins may have an impact on survival of older and younger patients with rectal cancer. MATERIALS AND METHODS:This study included 238 p...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.01.011
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:The majority of patients with chronic lymphocytic leukemia (CLL) are older and have multiple comorbidities, including other cancer diagnoses. These patients are routinely excluded from participation in clinical trials. OBJECTIVE:In this phase II study, we determined the activity and toxicity of ofatumumab, ...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2019.04.002
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVES:The global health status of older patients with cancer influences their clinical course, but little is known regarding the influence of the immune system on the global health of older patients with cancer. The goal of this study was to assess the relationships between patient fitness/frailty status and survi...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jgo.2018.03.021
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVE:To understand how older persons with multiple chronic conditions (MCC) approach decisions about cancer screening. MATERIALS AND METHODS:We conducted interviews with adults >65 years old with at least two chronic conditions who were taking ≥five medications daily. Patients were first asked how age and multimo...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2014.12.001
更新日期：2015-03-01 00:00:00
abstract：OBJECTIVE:To date, most comorbidity studies have analyzed either a subgroup of frequent diseases, or used summary instruments such as the Charlson score or the Cumulative Illness Rating Scale-Geriatric (CIRS-G). Yet, comorbidity is a multidimensional construct and impacts function, treatment tolerance, and survival. We...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2017.07.005
更新日期：2017-09-01 00:00:00
abstract：INTRODUCTION:Older adults with cancer are at increased risk of delirium due to age, comorbidities, medications, cognitive impairment, and possibly cancer treatments. However, there is scant information on the risks of delirium with chemotherapy and approaches to prevent or treat it. We performed a systematic review and...
journal_title：Journal of geriatric oncology
pub_type： 杂志文章
doi：10.1016/j.jgo.2020.08.011
更新日期：2020-09-14 00:00:00
