Abstract:
OBJECTIVES:Older breast cancer survivors (BCS) consistently report more functional limitations than women without cancer, but whether or not these differences remain when using objective measures of physical functioning and the correlates of these measures is unknown. METHODS:Cross-sectional study comparing older (≥60 years old) BCS (n = 84) to similarly aged women without cancer (n = 40). Patient-reported physical function was assessed by the SF-36 physical function (SF-36PF) subscale and the Late Life Function & Disability Instrument (LLFDI). Objective measures included the short Physical Performance Battery (sPPB), usual walk speed (m/s), chair stand time (sec) and, grip strength (kg). Potential predictors included age, comorbidities, symptom severity, fatigue and skeletal muscle index (SMI; kg/m2). RESULTS:Patient-reported physical function was significantly lower in BCS than controls using SF-36PF (47.3 ± 0.1 vs. 52.9 ± 4.0, p < 0.001) and LLFDI (68.2 ± 10.5 vs. 75.0 ± 8.9, p = 0.001). BCS had significantly lower sPPB scores (10.7 ± 0.1 vs. 11.7 ± 0.5, p < 0.001), longer chair stand times (12.6 ± 3.7 vs. 10.1 ± 1.4 s, p < 0.001), and lower handgrip strength (22.3 ± 5.0 vs. 24.3 ± 4.4 kg, p = 0.03) than controls, but similar walk speed (1.1+0.2 vs. 1.1+0.1 m/s, p = 0.75). Within BCS, age, comorbidities, SMI, symptom severity and fatigue explained 17.3%-33.1% of the variance across physical function measures. Fatigue was the variable most consistently associated with patient-reported physical functioning and age and comorbidities were the variables most consistently associated with objectively measured physical functioning. CONCLUSION:Older BCS should be screened for functional limitations using simple standardized objective tests and interventions that focus on improving strength and reducing fatigue should be tested.
journal_name
J Geriatr Oncoljournal_title
Journal of geriatric oncologyauthors
Winters-Stone KM,Medysky ME,Savin MAdoi
10.1016/j.jgo.2018.10.006subject
Has Abstractpub_date
2019-03-01 00:00:00pages
311-316issue
2eissn
1879-4068issn
1879-4076pii
S1879-4068(18)30209-1journal_volume
10pub_type
杂志文章abstract:OBJECTIVES:Little is known about how psychosocial factors and distress affect older patients with cancer and their survival. The study goals were to: 1) observe the prevalence of anxiety (ANX) and depression (DEP) symptoms at diagnosis in patients aged ≥65 years, 2) observe the association between social isolation (iso...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2020.10.001
更新日期:2020-11-04 00:00:00
abstract:OBJECTIVE:Elderly patients with cancer are under-represented in clinical trials, and there is especially scant data on their participation in early-phase trials. In an effort to provide more data, we reviewed our Phase I experience. METHODS:We conducted a retrospective analysis of 461 patients enrolled in Phase I clin...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2013.08.005
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:This study aims to (1) describe the activities, function, and health-related quality of life (HRQOL) of a large sample of older adults (age ≥65) with cancer, (2) identify the associations with demographics, cancer type, comorbid conditions, and ability to participate in activities and functional status. MATE...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2017.02.009
更新日期:2017-07-01 00:00:00
abstract:INTRODUCTION:Older adults are underrepresented in landmark trials that determine treatment guidelines for pancreatic cancer. We used the National Cancer Database (NCDB) to compare treatment patterns and outcomes in stage I-III pancreatic cancer between older adult patients, defined as age 80 or older, to patients young...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2019.12.006
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:To understand how older persons with multiple chronic conditions (MCC) approach decisions about cancer screening. MATERIALS AND METHODS:We conducted interviews with adults >65 years old with at least two chronic conditions who were taking ≥five medications daily. Patients were first asked how age and multimo...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2014.12.001
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Metastasectomy has a curative potential in colon cancer, but its benefits have not been ascertained in population data. Our objective was to evaluate utilization of metastasectomy in colon cancer and its survival outcomes in groups defined by different age at diagnosis, tumor grade or varying extent of nodal...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2015.08.002
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVES:HER2 (human epidermal growth factor receptor 2) is an important biomarker in breast cancer, but its prevalence in elderly women is not well established. Previous studies reported HER2 status based on either immunohistochemistry (IHC) or fluorescent in situ hybridization (FISH) interchangeably. However, the t...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2013.05.007
更新日期:2013-10-01 00:00:00
abstract:PURPOSE:Although the year after cancer treatment is challenging for all cancer survivors, older adults (≥60 years) face additional challenges due to age-related decline and high rates of comorbidity. There is a paucity of research on how health service interruptions from the COVID-19 pandemic have impacted the experien...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2020.11.009
更新日期:2020-12-03 00:00:00
abstract::Median age at bladder cancer (BC) diagnosis is older than for other major tumours. Age should not determine treatment, and patients should be fully involved in decisions. Patients should be screened with Mini-Cog™ for cognitive impairment and the G8 to ascertain need for comprehensive geriatric assessment. In non-musc...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章,评审
doi:10.1016/j.jgo.2020.02.001
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:Family caregiver burden among older adults with advanced cancer remains poorly understood. We sought to (1) identify patient factors associated with caregiver burden and (2) examine how amount of time caregiving modifies these relationships. METHODS:Cross-sectional analysis of baseline data from a cluster-r...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2021.01.002
更新日期:2021-01-18 00:00:00
abstract:OBJECTIVES:This study aims to investigate the use of chemotherapy with or without bevacizumab in older patients with metastatic colorectal cancer (mCRC) in current daily practice and to identify predictive parameters for treatment-related outcomes. PATIENTS AND METHODS:This is a Belgian multi-centre, observational coh...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jgo.2017.10.002
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Geriatric assessment (GA) is an appropriate method for identifying frailty in older patients with cancer, but a shorter instrument may be easier to use in clinical practice. Clinical judgment is always available and requires no investments in time or resources. The purpose of this study was to assess correla...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2020.05.011
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:Older patients with brain metastases (BM) are often excluded from clinical trials. The aim of our study was to investigate the outcomes following Gamma Knife radiosurgery (GKRS) in young old (65-74 years) and very old (≥75 years) patients with BM. METHODS:Between October 2012 and October 2018, we treated 89 pa...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2020.03.009
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to develop a new brief, comprehensive geriatric assessment scale for older patients diagnosed with different hematological malignancies, the Geriatric Assessment in Hematology (GAH scale), and to determine its psychometric properties. MATERIALS AND METHODS:The 30-item GAH scale...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jgo.2015.03.003
更新日期:2015-09-01 00:00:00
abstract:PURPOSE:With the aging population, our current understanding of patients with cancer and their family caregivers needs to be expanded to older patients with cancer and their caregivers. By differentiating spousal caregivers and non-spousal caregivers, we aimed to investigate the universalities and particularities of ca...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2019.05.020
更新日期:2020-01-01 00:00:00
abstract::Multidisciplinary teams (MDTs) have been incorporated into the practical care of elderly patients with cancer. Several geriatric oncology centres have attempted to determine the best way to implement MDTs by using geriatric assessment (GA). Developing a geriatric oncology service is a feasible work, which requires sig...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章,评审
doi:10.1016/j.jgo.2016.07.001
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:The majority of patients with chronic lymphocytic leukemia (CLL) are older and have multiple comorbidities, including other cancer diagnoses. These patients are routinely excluded from participation in clinical trials. OBJECTIVE:In this phase II study, we determined the activity and toxicity of ofatumumab, ...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2019.04.002
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Because of comorbidities and polypharmacy, older patients with cancer have a greater risk of iatrogenic events. We aimed to characterize potential drug-drug interactions (PDIs) and the risk of unplanned hospitalization in older patients with cancer treated with antineoplastic agents (ANAs). METHODS:We analy...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2019.07.023
更新日期:2020-05-01 00:00:00
abstract::Studies on cancer survival have revealed disparities not only between the elderly and their younger counterparts, but also among the elderly themselves. The aim of this work was to identify sociodemographic, socioeconomic, clinical, and care-related determinants of survival or mortality in older patients with cancer b...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2017.07.007
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:No tools accurately discriminate between older patients who are fit and those who are frail to tolerate systemic palliative treatment. This study evaluates whether domains of geriatric assessment (GA) are associated with increased risk of chemotherapy intolerance in patients who were considered fit to start ...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2019.05.016
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVES:To establish whether clinicopathologic and genomic characteristics may explain the poor prognosis associated with advanced age in ER+/HER2- breast cancer. MATERIALS AND METHODS:The cohort included 271 consecutive post-menopausal patients with ER+/HER2- invasive breast cancer ages 55 years and older. Patient...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2020.08.007
更新日期:2020-08-25 00:00:00
abstract:BACKGROUND:Cancer in the aging population presents manifold challenges. In the resource-limited settings of developing countries, concrete steps to optimize care for older adults with cancer are required. MATERIALS AND METHOD:This prospective, observational study was divided in two parts. In the first part, older adul...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2020.04.013
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVES:Older patients with cancer have increased risk for comorbidity, polypharmacy (PP) and drug related problems (DRP). The aim of this study was to assess the effect of a clinical pharmacist and geriatrician medication review (MR) among older outpatients with cancer to optimize management of comorbidities during...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2020.07.010
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:To assess adjuvant chemotherapy recommendations, administration and disease-specific survival for invasive breast cancer (BC) among patients 75years and older compared with that of younger women. MATERIALS AND METHODS:A cohort of patients with primary breast cancer, aged 65-94, stages I-III from 1990 to 2010...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2012.12.007
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:In this study, we evaluated the Groningen Frailty Indicator (GFI) and the G8 questionnaire as screening tools for a Comprehensive Geriatric Assessment (CGA) in older patients with cancer. PATIENTS AND METHODS:Eligible patients with various types and stages of cancer were evaluated for frailty before treatmen...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jgo.2012.08.001
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Clinical trials investigating breast cancer treatment often exclude or misrepresent older adults. This study compares treatment patterns and survival of older women diagnosed with breast cancer between a Dutch and a British observational cohort. MATERIALS AND METHODS:Women aged 70 years and older diagnosed w...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2018.05.004
更新日期:2018-11-01 00:00:00
abstract::The authors regret: A calculation error was corrected in Table 3. As mentioned under the table, the percentage of patients under ‘Baseline’ was calculated from the total no. of patients with geriatric recommendations data (n = 932 pts). This was mistakenly calculated from the number of patients with available GA data ...
journal_title:Journal of geriatric oncology
pub_type: 已发布勘误
doi:10.1016/j.jgo.2016.01.005
更新日期:2016-03-01 00:00:00
abstract::The aging of the population is a global challenge. The number of older adults is rapidly growing, leading to an increase in the prevalence of noncommunicable diseases associated with aging, such as cancer. Worldwide, older adults account for approximately half of all cancer cases, and this proportion is projected to i...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章,评审
doi:10.1016/j.jgo.2017.06.001
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVES:We investigated whether advanced age affects peri-operative outcomes after robotic-assisted pulmonary lobectomies. MATERIALS AND METHODS:We retrospectively analyzed patients who underwent robotic-assisted lobectomy by one surgeon over a 5-year period. Rates of postoperative complications were compared accor...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2016.11.003
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:To investigate changes in inflammatory biomarkers during induction therapy for older adults with acute myeloid leukemia (AML) and their associations with geriatric assessment (GA) measures and outcomes. METHODS:This was a single institution ancillary study to a prospective observational study (N = 20 consec...
journal_title:Journal of geriatric oncology
pub_type: 杂志文章
doi:10.1016/j.jgo.2019.03.014
更新日期:2020-04-01 00:00:00