The biomechanics of simple steatosis and steatohepatitis.

Abstract:

:Magnetic resonance and ultrasound elastography techniques are now important tools for staging high-grade fibrosis in patients with chronic liver disease. However, uncertainty remains about the effects of simple accumulation of fat (steatosis) and inflammation (steatohepatitis) on the parameters that can be measured using different elastographic techniques. To address this, we examine the rheological models that are capable of capturing the dominant viscoelastic behaviors associated with fat and inflammation in the liver, and quantify the resulting changes in shear wave speed and viscoelastic parameters. Theoretical results are shown to match measurements in phantoms and animal studies reported in the literature. These results are useful for better design of elastographic studies of fatty liver disease and steatohepatitis, potentially leading to improved diagnosis of these conditions.

journal_name

Phys Med Biol

authors

Parker KJ,Ormachea J,Drage MG,Kim H,Hah Z

doi

10.1088/1361-6560/aac09a

subject

Has Abstract

pub_date

2018-05-17 00:00:00

pages

105013

issue

10

eissn

0031-9155

issn

1361-6560

journal_volume

63

pub_type

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