Assessment of thermal effects in a model of the human head implanted with a wireless active microvalve for the treatment of glaucoma creating a filtering bleb.

Abstract:

:A 3D anatomical computational model is developed to assess thermal effects due to exposure to the electromagnetic field required to power a new investigational active implantable microvalve for the treatment of glaucoma. Such a device, located in the temporal superior eye quadrant, produces a filtering bleb, which is included in the geometry of the model, together with the relevant ocular structures. The electromagnetic field source-a planar coil-as well as the microvalve antenna and casing are also included. Exposure to the electromagnetic field source of an implanted and a non-implanted subject are simulated by solving a magnetic potential formulation, using the finite element method. The maximum SAR10 is reached in the eyebrow and remains within the limits suggested by the IEEE and ICNIRP standards. The anterior chamber, filtering bleb, iris and ciliary body are the ocular structures where more absorption occurs. The temperature rise distribution is also obtained by solving the bioheat equation with the finite element method. The numerical results are compared with the in vivo measurements obtained from four rabbits implanted with the microvalve and exposed to the electromagnetic field source.

journal_name

Phys Med Biol

authors

Schaumburg F,Guarnieri FA

doi

10.1088/1361-6560/aa5dae

subject

Has Abstract

pub_date

2017-05-07 00:00:00

pages

N191-N203

issue

9

eissn

0031-9155

issn

1361-6560

journal_volume

62

pub_type

杂志文章
  • On the total system error of a robotic radiosurgery system: phantom measurements, clinical evaluation and long-term analysis.

    abstract::The total system error (TSE) of a CyberKnife® system was measured using two phantom-based methods and one patient-based method. The standard radiochromic film (RCF) end-to-end (E2E) test using an anthropomorphic head and neck phantom and isocentric treatment delivery was used with the 6Dskull, Fiducial and Xsight® spi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aad516

    authors: Pantelis E,Moutsatsos A,Antypas C,Zoros E,Pantelakos P,Lekas L,Romanelli P,Zourari K,Hourdakis CJ

    更新日期:2018-08-20 00:00:00

  • Classification of movement intention by spatially filtered electromagnetic inverse solutions.

    abstract::We couple standardized low-resolution electromagnetic tomography, an inverse solution for electroencephalography (EEG) and the common spatial pattern, which is here conceived as a data-driven beamformer, to classify the benchmark BCI (brain-computer interface) competition 2003, data set IV. The data set is from an exp...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/51/8/002

    authors: Congedo M,Lotte F,Lécuyer A

    更新日期:2006-04-21 00:00:00

  • Development of a fast Monte Carlo dose calculation system for online adaptive radiation therapy quality assurance.

    abstract::Online adaptive radiation therapy (ART) based on real-time magnetic resonance imaging represents a paradigm-changing treatment scheme. However, conventional quality assurance (QA) methods based on phantom measurements are not feasible with the patient on the treatment couch. The purpose of this work is to develop a fa...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aa6e38

    authors: Wang Y,Mazur TR,Park JC,Yang D,Mutic S,Li HH

    更新日期:2017-06-21 00:00:00

  • Comparison of recent codes of practice for high-energy photon dosimetry.

    abstract::Absorbed dose values were determined under the reference conditions in a phantom irradiated by high-energy photon beams with quality varying between 60Co gamma rays and 25 MV X-rays, using four commonly employed types of ionisation chamber. The ionisation chamber readings were converted to absorbed dose values applyin...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/31/4/006

    authors: Mijnheer BJ,Wittkämper FW

    更新日期:1986-04-01 00:00:00

  • On the dosimetric behaviour of photon dose calculation algorithms in the presence of simple geometric heterogeneities: comparison with Monte Carlo calculations.

    abstract::A comparative study was performed to reveal differences and relative figures of merit of seven different calculation algorithms for photon beams when applied to inhomogeneous media. The following algorithms were investigated: Varian Eclipse: the anisotropic analytical algorithm, and the pencil beam with modified Batho...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/5/011

    authors: Fogliata A,Vanetti E,Albers D,Brink C,Clivio A,Knöös T,Nicolini G,Cozzi L

    更新日期:2007-03-07 00:00:00

  • Evaluation of inverse methods and head models for EEG source localization using a human skull phantom.

    abstract::We used a real-skull phantom head to investigate the performances of representative methods for EEG source localization when considering various head models. We describe several experiments using a montage with current sources located at multiple positions and orientations inside a human skull filled with a conductive...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/46/1/306

    authors: Baillet S,Riera JJ,Marin G,Mangin JF,Aubert J,Garnero L

    更新日期:2001-01-01 00:00:00

  • Performance of isotropic light dosimetry probes based on scattering bulbs in turbid media.

    abstract::In a previous paper the calibration of an isotropic light detector in clear media was described and validated. However, in most applications the detector is used to measure light distribution in turbid (scattering) media, that is, in tissues or tissue equivalent optical phantoms. Despite its small diameter (typically ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/47/12/304

    authors: Marijnissen JP,Star WM

    更新日期:2002-06-21 00:00:00

  • Full-field speckle interferometry for non-contact photoacoustic tomography.

    abstract::A full-field speckle interferometry method for non-contact and prospectively high speed Photoacoustic Tomography is introduced and evaluated as proof of concept. Thermoelastic pressure induced changes of the objects topography are acquired in a repetitive mode without any physical contact to the object. In order to ob...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/60/10/4045

    authors: Horstmann J,Spahr H,Buj C,Münter M,Brinkmann R

    更新日期:2015-05-21 00:00:00

  • Investigation of detection limits for diffuse optical tomography systems: II. Analysis of slab and cup geometry for breast imaging.

    abstract::Using a statistical (chi-square) test on simulated data and a realistic noise model derived from the system's hardware we study the performance of diffuse optical tomography systems for fluorescence imaging. We compare the predicted smallest size of detectable lesions at various positions in slab and cup geometry and ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/54/2/016

    authors: Ziegler R,Brendel B,Rinneberg H,Nielsen T

    更新日期:2009-01-21 00:00:00

  • Limitations of clinical CT in assessing cortical thickness and density.

    abstract::The peak CT number (CT) and full width at half maximum (FWHM) were obtained from the image profiles of aluminium of thickness ranging from 0.1-9.5 mm. The scans were performed at different fields of view (FOVs) and with different reconstruction algorithms ('bone' and 'standard'). Above 3 mm, CT and FWHM provide measur...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/43/3/013

    authors: Newman DL,Dougherty G,al Obaid A,al Hajrasy H

    更新日期:1998-03-01 00:00:00

  • Liver-ultrasound based motion modelling to estimate 4D dose distributions for lung tumours in scanned proton therapy.

    abstract::Motion mitigation strategies are crucial for scanned particle therapy of mobile tumours in order to prevent geometrical target miss and interplay effects. We developed a patient-specific respiratory motion model based on simultaneously acquired time-resolved volumetric MRI and 2D abdominal ultrasound images. We presen...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/abaa26

    authors: Giger AT,Krieger M,Jud C,Duetschler A,Salomir R,Bieri O,Bauman G,Nguyen D,Weber DC,Lomax AJ,Zhang Y,Cattin PC

    更新日期:2020-07-28 00:00:00

  • Reducing 4DCBCT imaging time and dose: the first implementation of variable gantry speed 4DCBCT on a linear accelerator.

    abstract::Four dimensional cone beam computed tomography (4DCBCT) uses a constant gantry speed and imaging frequency that are independent of the patient's breathing rate. Using a technique called respiratory motion guided 4DCBCT (RMG-4DCBCT), we have previously demonstrated that by varying the gantry speed and imaging frequency...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/62/11/4300

    authors: O'Brien RT,Stankovic U,Sonke JJ,Keall PJ

    更新日期:2017-06-07 00:00:00

  • Simulation study of the second-generation MR-compatible SPECT system based on the inverted compound-eye gamma camera design.

    abstract::In this paper, we present simulation studies for the second-generation MRI compatible SPECT system, MRC-SPECT-II, based on an inverted compound eye (ICE) gamma camera concept. The MRC-SPECT-II system consists of a total of 1536 independent micro-pinhole-camera-elements (MCEs) distributed in a ring with an inner diamet...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aaa4fb

    authors: Lai X,Meng LJ

    更新日期:2018-02-12 00:00:00

  • A theoretical comparison of energy sources--microwave, ultrasound and laser--for interstitial thermal therapy.

    abstract::A number of heating sources are available for minimally invasive thermal therapy of tumours. The purpose of this work was to compare, theoretically, the heating characteristics of interstitial microwave, laser and ultrasound sources in three tissue sites: breast, brain and liver. Using a numerical method, the heating ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/43/12/011

    authors: Skinner MG,Iizuka MN,Kolios MC,Sherar MD

    更新日期:1998-12-01 00:00:00

  • Assessment of noise in a digital image using the join-count statistic and the Moran test.

    abstract::We assume that the data bits of a pixel in digital images can be divided into signal and noise bits. The signal bits occupy the most significant part of the pixel and the noise bits the least significant part. The signal part of each pixel are correlated while the noise parts are uncorrelated. Two statistical methods,...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/37/2/004

    authors: Chuang KS,Huang HK

    更新日期:1992-02-01 00:00:00

  • Determination of elemental tissue composition following proton treatment using positron emission tomography.

    abstract::Positron emission tomography (PET) has been suggested as an imaging technique for in vivo proton dose and range verification after proton induced-tissue activation. During proton treatment, irradiated tissue is activated and decays while emitting positrons. In this paper, we assessed the feasibility of using PET imagi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/58/11/3815

    authors: Cho J,Ibbott G,Gillin M,Gonzalez-Lepera C,Min CH,Zhu X,El Fakhri G,Paganetti H,Mawlawi O

    更新日期:2013-06-07 00:00:00

  • Characterization of a preclinical PET insert in a 7 Tesla MRI scanner: beyond NEMA testing.

    abstract::This study evaluates the performance of the Bruker positron emission tomograph (PET) insert combined with a BioSpec 70/30 USR magnetic resonance imaging (MRI) scanner using the manufacturer acceptance protocol and the NEMA NU 4-2008 for small animal PET. The PET insert is made of 3 rings of 8 monolithic LYSO crystals ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aba08c

    authors: Gsell W,Molinos C,Correcher C,Belderbos S,Wouters J,Junge S,Heidenreich M,Vande Velde G,Rezaei A,Nuyts J,Cawthorne C,Cleeren F,Nannan L,Deroose CM,Himmelreich U,González Martínez AJ

    更新日期:2020-06-26 00:00:00

  • A multiplicative correction factor for tissue heterogeneities.

    abstract::A new multiplicative correction factor for tissue heterogeneities based on an exact expression for homogeneous non-unit-density media is proposed. O'Connor's density scaling theorem is invoked to evaluate the medium-specific tissue-maximum ratios used in the exact formulation. Monte Carlo calculations were performed a...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/31/10/005

    authors: Petti PL,Siddon RL,Bjärngard BE

    更新日期:1986-10-01 00:00:00

  • Spectrum reconstruction from dose measurements as a linear inverse problem.

    abstract::There are three ways to determine the spectrum of a clinical photon beam: direct measurement, modelling the source and reconstruction from ion-chamber measurements. We focus on reconstruction because the necessary equipment is readily available and it provides independent confirmation of source models for a given mach...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/49/22/005

    authors: Armbruster B,Hamilton RJ,Kuehl AK

    更新日期:2004-11-21 00:00:00

  • Modelling the electrical properties of tissue as a porous medium.

    abstract::Models of the electrical properties of biological tissue have been the subject of many studies. These models have sought to explain aspects of the dielectric dispersion of tissue. This paper develops a mathematical model of the complex permittivity of tissue as a function of frequency f, in the range 10(4) < f < 10(7)...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/23/016

    authors: Smye SW,Evans CJ,Robinson MP,Sleeman BD

    更新日期:2007-12-07 00:00:00

  • Dual-head gamma camera system for intraoperative localization of radioactive seeds.

    abstract::Breast-conserving surgery is a standard option for the treatment of patients with early-stage breast cancer. This form of surgery may result in incomplete excision of the tumor. Iodine-125 labeled titanium seeds are currently used in clinical practice to reduce the number of incomplete excisions. It seems likely that ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/60/19/7655

    authors: Arsenali B,de Jong HW,Viergever MA,Dickerscheid DB,Beijst C,Gilhuijs KG

    更新日期:2015-10-07 00:00:00

  • Fluorescence-enhanced three-dimensional lifetime imaging: a phantom study.

    abstract::Near-infrared fluorescence optical imaging has the unique opportunity of differentiating diseased lesions from normal lesions based upon environmentally indicated changes in the lifetime of a fluorescent imaging agent. In this paper, we demonstrate three-dimensional lifetime tomography using the gradient-based penalty...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/14/009

    authors: Roy R,Godavarty A,Sevick-Muraca EM

    更新日期:2007-07-21 00:00:00

  • Measurement of effective detective quantum efficiency for a photon counting scanning mammography system and comparison with two flat panel full-field digital mammography systems.

    abstract::Effective detective quantum efficiency (eDQE) describes the resolution and noise properties of an imaging system along with scatter and primary transmission, all measured under clinically appropriate conditions. Effective dose efficiency (eDE) is the eDQE normalised to mean glandular dose and has been proposed as a us...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aaa307

    authors: Wood TJ,Moore CS,Saunderson JR,Beavis AW

    更新日期:2018-01-16 00:00:00

  • Development of a synthetic single crystal diamond dosimeter for dose measurement of clinical proton beams.

    abstract::The scope of this work was to develop a synthetic single crystal diamond dosimeter (SCDD-Pro) for accurate relative dose measurements of clinical proton beams in water. Monte Carlo simulations were carried out based on the MCNPX code in order to investigate and reduce the dose curve perturbation caused by the SCDD-Pro...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aa70cf

    authors: Moignier C,Tromson D,de Marzi L,Marsolat F,García Hernández JC,Agelou M,Pomorski M,Woo R,Bourbotte JM,Moignau F,Lazaro D,Mazal A

    更新日期:2017-07-07 00:00:00

  • Total body water measurements using resonant cavity perturbation techniques.

    abstract::A recent paper proposed a novel technique for determining the total body water (TBW) of patients suffering with abnormal hydration levels, using a resonant cavity perturbation method. Current techniques to measure TBW are limited by resolution and technical constraints. However, this new method involves measuring the ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/49/9/013

    authors: Stone DA,Robinson MP

    更新日期:2004-05-07 00:00:00

  • Bulk optical properties of healthy female breast tissue.

    abstract::We have measured the bulk optical properties of healthy female breast tissues in vivo in the parallel plate, transmission geometry. Fifty-two volunteers were measured. Blood volume and blood oxygen saturation were derived from the optical property data using a novel method that employed a priori spectral information t...

    journal_title:Physics in medicine and biology

    pub_type: 临床试验,杂志文章

    doi:10.1088/0031-9155/47/16/302

    authors: Durduran T,Choe R,Culver JP,Zubkov L,Holboke MJ,Giammarco J,Chance B,Yodh AG

    更新日期:2002-08-21 00:00:00

  • Assessment of histotripsy-induced liquefaction with diagnostic ultrasound and magnetic resonance imaging in vitro and ex vivo.

    abstract::Histotripsy is a therapeutic ultrasound modality under development to liquefy tissue mechanically via bubble clouds. Image guidance of histotripsy requires both quantification of the bubble cloud activity and accurate delineation of the treatment zone. In this study, magnetic resonance (MR) and diagnostic ultrasound i...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab143f

    authors: Anthony GJ,Bollen V,Hendley S,Antic T,Sammet S,Bader KB

    更新日期:2019-05-02 00:00:00

  • Modelling individual temperature profiles from an isolated perfused bovine tongue.

    abstract::To predict the temperature distribution during hyperthermia treatments a thermal model that accounts for the thermal effect of blood flow is mandatory. The DIscrete VAsculature (DIVA) thermal model developed at our department is able to do so; geometrically described vessels are handled individually and the remaining ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/45/3/314

    authors: Raaymakers BW,Crezee J,Lagendijk JJ

    更新日期:2000-03-01 00:00:00

  • Exact solutions to the multiregion time-dependent bioheat equation. II: Numerical evaluation of the solutions.

    abstract::Analytic solutions to the time-dependent multiregion bioheat equation are evaluated numerically for cartesian and spherical models. Principle and alternate branch contributions to the solutions are examined. The calculations include a parametric investigation and analyses of temperature behaviour in idealised upper th...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/35/7/005

    authors: Durkee JW Jr,Antich PP,Lee CE

    更新日期:1990-07-01 00:00:00

  • Automatic extraction of pectoral muscle in the MLO view of mammograms.

    abstract::A mammogram is the standard modality used for breast cancer screening. Computer-aided detection (CAD) approaches are helpful for improving breast cancer detection rates when applied to mammograms. However, automated analysis of a mammogram often leads to inaccurate results in the presence of the pectoral muscle. There...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/58/23/8493

    authors: Feudjio CK,Klein J,Tiedeu A,Colot O

    更新日期:2013-12-07 00:00:00