Lung morphometry using hyperpolarized 129 Xe multi-b diffusion MRI with compressed sensing in healthy subjects and patients with COPD.


PURPOSE:To demonstrate the feasibility of compressed sensing (CS) to accelerate the acquisition of hyperpolarized (HP) 129 Xe multi-b diffusion MRI for quantitative assessments of lung microstructural morphometry. METHODS:Six healthy subjects and six chronic obstructive pulmonary disease (COPD) subjects underwent HP 129 Xe multi-b diffusion MRI (b = 0, 10, 20, 30, and 40 s/cm2 ). First, a fully sampled (FS) acquisition of HP 129 Xe multi-b diffusion MRI was conducted in one healthy subject. The acquired FS dataset was retrospectively undersampled in the phase encoding direction, and an optimal twofold undersampled pattern was then obtained by minimizing mean absolute error (MAE) between retrospective CS (rCS) and FS MR images. Next, the FS and CS acquisitions during separate breath holds were performed on five healthy subjects (including the above one). Additionally, the FS and CS synchronous acquisitions during a single breath hold were performed on the sixth healthy subject and one COPD subject. However, only CS acquisitions were conducted in the rest of the five COPD subjects. Finally, all the acquired FS, rCS and CS MR images were used to obtain morphometric parameters, including acinar duct radius (R), acinar lumen radius (r), alveolar sleeve depth (h), mean linear intercept (Lm ), and surface-to-volume ratio (SVR). The Wilcoxon signed-rank test and the Bland-Altman plot were employed to assess the fidelity of the CS reconstruction. Moreover, the t-test was used to demonstrate the effectiveness of the multi-b diffusion MRI with CS in clinical applications. RESULTS:The retrospective results demonstrated that there was no statistically significant difference between rCS and FS measurements using the Wilcoxon signed-rank test (P > 0.05). Good agreement between measurements obtained with the CS and FS acquisitions during separate breath holds was demonstrated in Bland-Altman plots of slice differences. Specifically, the mean biases of the R, r, h, Lm , and SVR between the CS and FS acquisitions were 1.0%, 2.6%, -0.03%, 1.5%, and -5.5%, respectively. Good agreement between measurements with the CS and FS acquisitions was also observed during the single breath-hold experiments. Furthermore, there were significant differences between the morphometric parameters for the healthy and COPD subjects (P < 0.05). CONCLUSIONS:Our study has shown that HP 129 Xe multi-b diffusion MRI with CS could be beneficial in lung microstructural assessments by acquiring less data while maintaining the consistent results with the FS acquisitions.


Med Phys


Medical physics


Zhang H,Xie J,Xiao S,Zhao X,Zhang M,Shi L,Wang K,Wu G,Sun X,Ye C,Zhou X




Has Abstract


2018-07-01 00:00:00












  • Radionuclide photon dose kernels for internal emitter dosimetry.

    abstract::Photon point dose kernels and absorbed fractions were generated in water for the full photon emission spectrum of each radionuclide of interest in nuclear medicine, by simulating the transport of particles using Monte Carlo. The kernels were then fitted to a mathematical expression. Absorbed fractions for point source...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Furhang EE,Sgouros G,Chui CS

    更新日期:1996-05-01 00:00:00

  • Re-examining TG-142 recommendations in light of modern techniques for linear accelerator based radiosurgery.

    abstract:PURPOSE:The recent development of multifocal stereotactic radiosurgery (SRS) using a single isocenter volumetric modulated arc theory (VMAT) technique warrants a re-examination of the quality assurance (QA) tolerances for routine mechanical QA recommended by the American Association of Physicists in Medicine Task Group...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Faught AM,Trager M,Yin FF,Kirkpatrick J,Adamson J

    更新日期:2016-10-01 00:00:00

  • Regularized iterative weighted filtered backprojection for helical cone-beam CT.

    abstract::Contemporary reconstruction methods employed for clinical helical cone-beam computed tomography (CT) are analytical (noniterative) but mathematically nonexact, i.e., the reconstructed image contains so called cone-beam artifacts, especially for higher cone angles. Besides cone artifacts, these methods also suffer from...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Sunnegårdh J,Danielsson PE

    更新日期:2008-09-01 00:00:00

  • In vivo functional chronic imaging of a small animal model using optical-resolution photoacoustic microscopy.

    abstract::Optical-resolution photoacoustic microscopy (OR-PAM) has been validated as a valuable tool for label-free volumetric microvascular imaging. More importantly, the advantages of noninvasiveness and measurement consistency suggest the use of OR-PAM for chronic imaging of intact microcirculation. Here, such chronic imagin...

    journal_title:Medical physics

    pub_type: 信件


    authors: Hu S,Maslov K,Wang LV

    更新日期:2009-06-01 00:00:00

  • Characterization of trabecular bone plate-rod microarchitecture using multirow detector CT and the tensor scale: Algorithms, validation, and applications to pilot human studies.

    abstract:PURPOSE:Osteoporosis is a common bone disease associated with increased risk of low-trauma fractures leading to substantial morbidity, mortality, and financial costs. Clinically, osteoporosis is defined by low bone mineral density (BMD); however, increasing evidence suggests that trabecular bone (TB) microarchitectural...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Saha PK,Liu Y,Chen C,Jin D,Letuchy EM,Xu Z,Amelon RE,Burns TL,Torner JC,Levy SM,Calarge CA

    更新日期:2015-09-01 00:00:00

  • Obtaining S values for rectangular-solid tumors inside rectangular-solid host organs.

    abstract::A method is described for obtaining S values between a tumor and its host organ for use with the MIRD formalism. It applies the point-source specific absorbed fractions for an infinite water medium, tabulated by Berger, to a rectangular solid of arbitrary dimensions which contains a rectangular tumor of arbitrary dime...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Stinchcomb TG,Durham JS,Fisher DR

    更新日期:1991-05-01 00:00:00

  • Heating patterns of microwave applicators in inhomogeneous arm and thigh phantoms.

    abstract::Heating rate (HR) patterns in cylindrical structures were studied with inhomogeneous limb phantoms. These phantoms, arm and thigh models consisting of fat, bone, and muscle material, were heated with Clini-Therm L, M, and MS applicators at 915 MHz. The thigh model is 18 cm in diameter with 2.65-cm-thick fat on the out...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Chou CK,McDougall JA,Chan KW,Luk KH

    更新日期:1991-11-01 00:00:00

  • MOSFET dosimetry for microbeam radiation therapy at the European Synchrotron Radiation Facility.

    abstract::Preclinical experiments are carried out with approximately 20-30 microm wide, approximately 10 mm high parallel microbeams of hard, broad-"white"-spectrum x rays (approximately 50-600 keV) to investigate microbeam radiation therapy (MRT) of brain tumors in infants for whom other kinds of radiotherapy are inadequate an...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Bräuer-Krisch E,Bravin A,Lerch M,Rosenfeld A,Stepanek J,Di Michiel M,Laissue JA

    更新日期:2003-04-01 00:00:00

  • Segmentation of the prostate from suprapubic ultrasound images.

    abstract::We present a technique for semiautomated segmentation of human prostates using suprapubic ultrasound (US) images. In this approach, a speckle reducing anisotropic diffusion (SRAD) is applied to enhance the images and the instantaneous coefficient of variation (ICOV) is utilized for edge detection. Segmentation is acco...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Yu Y,Molloy JA,Acton ST

    更新日期:2004-12-01 00:00:00

  • Anatomy-based three-dimensional dose optimization in brachytherapy using multiobjective genetic algorithms.

    abstract::In conventional dose optimization algorithms, in brachytherapy, multiple objectives are expressed in terms of an aggregating function which combines individual objective values into a single utility value, making the problem single objective, prior to optimization. A multiobjective genetic algorithm (MOGA) was develop...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Lahanas M,Baltas D,Zamboglou N

    更新日期:1999-09-01 00:00:00

  • Iterative metal artifact reduction for x-ray computed tomography using unmatched projector/backprojector pairs.

    abstract:PURPOSE:Metal artifact reduction (MAR) is a major problem and a challenging issue in x-ray computed tomography (CT) examinations. Iterative reconstruction from sinograms unaffected by metals shows promising potential in detail recovery. This reconstruction has been the subject of much research in recent years. However,...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Zhang H,Wang L,Li L,Cai A,Hu G,Yan B

    更新日期:2016-06-01 00:00:00

  • Accuracy of deformable image registration on magnetic resonance images in digital and physical phantoms.

    abstract:PURPOSE:Accurate deformable image registration is necessary for longitudinal studies. The error associated with commercial systems has been evaluated using computed tomography (CT). Several in-house algorithms have been evaluated for use with magnetic resonance imaging (MRI), but there is still relatively little inform...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Ger RB,Yang J,Ding Y,Jacobsen MC,Fuller CD,Howell RM,Li H,Jason Stafford R,Zhou S,Court LE

    更新日期:2017-10-01 00:00:00

  • Fluid-filled dynamic bowtie filter: Description and comparison with other modulators.

    abstract:PURPOSE:A dynamic bowtie filter can modulate flux along both fan and view angles for reduced patient dose, scatter, and required photon flux, which is especially important for photon counting detectors (PCDs). Among the proposed dynamic bowtie designs, the piecewise-linear attenuator (Hsieh and Pelc, Med Phys. 2013;40:...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Shunhavanich P,Hsieh SS,Pelc NJ

    更新日期:2019-01-01 00:00:00

  • SU-E-T-159: Sensitivity of in Line Real Time Scintillating Fiber Detectors for External Beam Treatment Verification and Patient Safety.

    abstract:PURPOSE:We studied the sensitivity of a novel transmission fiber scintillator array designed and built for in line treatment verification. The purpose of this project is to assess the capability of the fiber detector array technology to detect treatment errors in real time without false positives to enhance patient saf...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Izaguirre EW,Price SG,Smajlovic S,Yaddanapudi S,Wooten H,Mutic S

    更新日期:2012-06-01 00:00:00

  • Strategies for scatter correction in dual source CT.

    abstract:PURPOSE:Dual source CT (DSCT) systems utilize two measurement systems (A) and (B) offset by about 90 degrees. A special challenge in DSCT is cross-scattered radiation, i.e., scattered radiation from x-ray tube (B) detected in detector (A) and vice versa. Cross-scattered radiation can produce artifacts and degrade the c...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Petersilka M,Stierstorfer K,Bruder H,Flohr T

    更新日期:2010-11-01 00:00:00

  • Innovative methodology for intercomparison of radionuclide calibrators using short half-life in situ prepared radioactive sources.

    abstract:PURPOSE:An original radionuclide calibrator method for activity determination is presented. The method could be used for intercomparison surveys for short half-life radioactive sources used in Nuclear Medicine, such as(99m)Tc or most positron emission tomography radiopharmaceuticals. METHODS:By evaluation of the resul...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Oliveira PA,Santos JA

    更新日期:2014-07-01 00:00:00

  • Evaluation of carbon nanotube x-ray source array for stationary head computed tomography.

    abstract:PURPOSE:Stationary computed tomography (s-CT) conceptually offers several advantages over existing rotating gantry-based CT. Over the last 40 yr, s-CT has been investigated using different technological approaches. We are developing a s-CT system specifically for head/brain imaging using carbon nanotube (CNT)-based fie...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Spronk D,Luo Y,Inscoe CR,Lee YZ,Lu J,Zhou O

    更新日期:2020-12-31 00:00:00

  • Carpal tunnel syndrome diagnosis by a self-normalization process and ultrasound compound imaging.

    abstract:PURPOSE:Carpal tunnel syndrome (CTS) is the common entrapment neuropathy that occurs due to compression of the median nerve at the wrist. Ultrasound images have been used to highlight anatomical variants of the median nerve, and CTS is thought to be associated to enlargement of the cross-sectional area (CSA) of the med...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Liao YY,Wu CC,Kuo TT,Chen JP,Hsu YW,Yeh CK

    更新日期:2012-12-01 00:00:00

  • Robust optimization in IMPT using quadratic objective functions to account for the minimum MU constraint.

    abstract:PURPOSE:Currently, in clinical practice of intensity-modulated proton therapy (IMPT), the influence of the minimum monitor unit (MU) constraint is taken into account through postprocessing after the optimization is completed. This may degrade the plan quality and plan robustness. This study aims to mitigate the impact ...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Shan J,An Y,Bues M,Schild SE,Liu W

    更新日期:2018-01-01 00:00:00

  • Tracking the dynamic seroma cavity using fiducial markers in patients treated with accelerated partial breast irradiation using 3D conformal radiotherapy.

    abstract:PURPOSE:The purpose of the present study was to perform an analysis of the changes in the dynamic seroma cavity based on fiducial markers in early stage breast cancer patients treated with accelerated partial breast irradiation (APBI) using three-dimensional conformal external beam radiotherapy (3D-CRT). METHODS:A pro...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Yue NJ,Haffty BG,Kearney T,Kirstein L,Chen S,Goyal S

    更新日期:2013-02-01 00:00:00

  • Automatic measurements of image geometry for online calibration of C-arm fluoroscopy.

    abstract::Calibrated C-arm fluoroscopy is used for a variety of surgical procedures where surgical tools and anatomical structures need to be located in space. Calibration can be performed online by combining measurements of the geometry of the image (center and radius) with measurements of a grid of fiducial markers. This arti...

    journal_title:Medical physics

    pub_type: 杂志文章,多中心研究


    authors: Archip N,Rohling R

    更新日期:2004-09-01 00:00:00

  • Computation of beam quality parameters for Mo/Mo, Mo/Rh, Rh/Rh, and W/Al target/filter combinations in mammography.

    abstract::A computer program was implemented to predict mammography x-ray beam parameters in the range 20-40 kV for Mo/Mo, Mo/Rh, Rh/Rh, and W/Al target/filter combinations. The computation method used to simulate mammography x-ray spectra is based on the Boone et al. model. The beam quality parameters such as the half-value la...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Kharrati H,Zarrad B

    更新日期:2003-10-01 00:00:00

  • SU-D-BRA-02: An Extended Time-Variant Seasonal Autoregressive Model-Based Prediction for Irregular Breathing Motion Tracking.

    abstract:PURPOSE:Real-time tumor position/shape measurement and dynamic beam tracking techniques allow accurate and continuous irradiation to moving tumor, but there can be a delay of several hundred milliseconds between observation and irradiation. A time-variant seasonal autoregressive (TVSAR) model has been proposed for comp...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Ichiji K,Homma N,Sakai M,Narita Y,Takai Y,Yoshizawa M

    更新日期:2012-06-01 00:00:00

  • Photon attenuation in computed tomography.

    abstract::The analysis and understanding of results of computed tomography (CT) require an understanding of photon attenuation in matter. The high sensitivity and resolution of these devices coupled with the use of a polychromatic photon source require a level and breadth of understanding about photon attenuation not usually re...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: McCullough EC

    更新日期:1975-11-01 00:00:00

  • A method to compare supra-pubic ultrasound and CT images of the prostate: technique and early clinical results.

    abstract::We describe a unique method that allows the comparison of spatially registered ultrasound (SRUS) images and computed tomography-derived contours (CTDCs) that were acquired with a minimal time lapse. As such, we have a tool that will provide validation of the spatial accuracy of the US system and that will allow compar...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Molloy JA,Srivastava S,Schneider BF

    更新日期:2004-03-01 00:00:00

  • Optimization of MR pulse sequences for Bayesian image segmentation.

    abstract::A method for optimizing MR imaging pulse sequence parameters in a statistical framework is presented. Parameters are defined to be optimal when the resulting scalar images yield optimal image segmentations using Bayesian pixel classification. Thus, Bayes risk is used as the objective function to minimize. Approximatio...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Prince JL,Pham D,Tan O

    更新日期:1995-10-01 00:00:00

  • Use of the fast Hartley transform for three-dimensional dose calculation in radionuclide therapy.

    abstract::Effective radioimmunotherapy may depend on a priori knowledge of the radiation absorbed dose distribution obtained by trace imaging activities administered to a patient before treatment. A new, fast, and effective treatment planning approach is developed to deal with a heterogeneous activity distribution. Calculation ...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Erdi AK,Yorke ED,Loew MH,Erdi YE,Sarfaraz M,Wessels BW

    更新日期:1998-11-01 00:00:00

  • Characteristics of sensitometric curves of radiographic films.

    abstract::A new type of radiographic film, EDR (extended dose range) film, has been recently become available for film dosimetry. It is particularly attractive for composite isodose verification of intensity modulated radiation therapy because of its low sensitivity relative to the more common Kodak XV film. For XV film, the re...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Zhu XR,Yoo S,Jursinic PA,Grimm DF,Lopez F,Rownd JJ,Gillin MT

    更新日期:2003-05-01 00:00:00

  • Automated matching and segmentation of lymphoma on serial CT examinations.

    abstract::In patients with lymphoma, identification and quantification of the tumor extent on serial CT examinations is critical for assessing tumor response to therapy. In this paper, we present a computer method to automatically match and segment lymphomas in follow-up CT images. The method requires that target lymph nodes in...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Yan J,Zhao B,Curran S,Zelenetz A,Schwartz LH

    更新日期:2007-01-01 00:00:00

  • Development and clinical implementation of semi-automated treatment planning including 3D printable applicator holders in complex skin brachytherapy.

    abstract:PURPOSE:High-dose-rate brachytherapy (HDR-BT) is a treatment option for malignant skin diseases compared to external beam radiation therapy, HDR-BT provides improved target coverage, better organ sparing, and has comparable treatment times. This is especially true for large clinical targets with complex topologies. To ...

    journal_title:Medical physics

    pub_type: 杂志文章


    authors: Guthier CV,Devlin PM,Harris TC,O'Farrell DA,Cormack RA,Buzurovic I

    更新日期:2020-03-01 00:00:00