Active immunization against varicella of children with acute leukaemia or other malignancies on maintenance chemotherapy.

Abstract:

:Twenty-six patients with acute leukaemia and other malignancies susceptible to varicella were vaccinated with the Oka-strain live attenuated varicella vaccine during maintenance chemotherapy. All recipients showed no adverse clinical reactions. There was no spread of vaccine virus. Seroconversion was 94% in seronegative patients. Among those having low antibody titres before vaccination, a booster effect was demonstrable in 56%. None of the seroconverted recipients contracted varicella despite documented contact exposure. No case of herpes zoster occurred. The results suggest that, in immunocompromised children, live varicella vaccination has a protective effect against varicella infection which may result in a mortality rate of up to 7% in these patients.

journal_name

Postgrad Med J

authors

Haas RJ,Belohradsky B,Dickerhoff R,Eichinger K,Eife R,Holtmann H,Goetz O,Graubner U,Peller P

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

69-72

eissn

0032-5473

issn

1469-0756

journal_volume

61 Suppl 4

pub_type

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