Severe acute respiratory syndrome (SARS): epidemiology and clinical features.


:Severe acute respiratory syndrome (SARS) is a newly emerged infectious disease with a significant morbidity and mortality. The major clinical features include persistent fever, chills/rigor, myalgia, malaise, dry cough, headache, and dyspnoea. Older subjects may present without the typical febrile response. Common laboratory features include lymphopenia, thrombocytopenia, raised alanine transaminases, lactate dehydrogenase, and creatine kinase. The constellation of compatible clinical and laboratory findings, together with certain characteristic radiological features and lack of clinical response to broad spectrum antibiotics, should arouse suspicion of SARS. Measurement of serum RNA by real time reverse transcriptase-polymerase chain reaction technique has a detection rate of 75%-80% in the first week of the illness.


Postgrad Med J


Hui DS,Chan MC,Wu AK,Ng PC




Has Abstract


2004-07-01 00:00:00














  • FAST-TIA: a prospective evaluation of a nurse-led anterior circulation TIA clinic.

    abstract:BACKGROUND:Transient ischaemic attacks (TIAs) carry a significant early risk of stroke. New national guidelines state patients should be seen within 7 days of the incident, with higher-risk patients being seen within 24 h. Meeting these targets across the NHS poses a significant challenge. A novel approach to TIA asses...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Banerjee S,Natarajan I,Biram R,Sutton K,Ekeng G,Ames D,Chataway J

    更新日期:2009-12-01 00:00:00

  • Acyclovir treatment of herpes simplex encephalitis: experience in a district hospital.

    abstract::Herpes simplex encephalitis may be underdiagnosed in Britain. We report eight patients treated at one hospital over three years. Fever, impaired consciousness or focal neurological signs were seen in all patients at presentation but herpes simplex encephalitis was rarely considered as the initial diagnosis. The electr...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Gulliford MC,Chandrasekera CP,Cooper RA,Murphy RP

    更新日期:1987-12-01 00:00:00

  • Normolipemic xanthomatosis.

    abstract::A 20-year-old woman presented with tendon and tuberous xanthomas. Plasma lipid levels were normal. Xanthomatosis with normal lipid levels is rare. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Handa R,Gupta K,Wali JP

    更新日期:1995-09-01 00:00:00

  • Crohn's disease and pericarditis.

    abstract::A patient is described who developed acute pericarditis during a severe first attack of Crohn's disease. The opportunity was taken to measure levels of circulating immune complexes, both during the acute phase of the illness and during convalescence; no significant change in these levels from normal values was found. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Manomohan V,Subbuswamy SG,Willoughby CP

    更新日期:1984-10-01 00:00:00

  • Diabetes insipidus complicating myelofibrosis.

    abstract::A 68 year old man developed cranial diabetes insipidus 3 years after the diagnosis of myelofibrosis, coincident with a marked increase in nucleated cell count. No mass lesion was demonstrable on computed tomographic or magnetic resonance imaging. It is suggested that hypothalamic damage was caused by local infiltratio...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Dornan TL,Gillett G,Jones PA,Jeffcoate WJ

    更新日期:1989-01-01 00:00:00

  • Early-onset dementia: key issues using a relationship-centred care approach.

    abstract::People with early-onset dementia have a potential risk of being marginalised with respect to care and social support as a result of the blame and stigma associated with their condition, and because they have reduced access to treatment options and postdiagnostic care. The limited use of community services and the resu...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: Nwadiugwu M

    更新日期:2020-09-03 00:00:00

  • The prevalence of potentially inappropriate medication prescribing in elderly patients with chronic kidney disease.

    abstract:INTRODUCTION:Potentially inappropriate medication (PIM) prescribing is a global problem. Limited data are available on the prevalence of PIMs in elderly patients with chronic kidney disease (CKD). We examined the PIM prevalence in elderly patients with CKD, the most common drugs implicated and the levels of polypharmac...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Jones SA,Bhandari S

    更新日期:2013-05-01 00:00:00

  • Evaluation of vaginal antifungal formulations in vivo.

    abstract::Relatively simple and rapid procedures have been developed for evaluating the local efficacy of vaginal antifungal agents in vivo in a vaginal candidiasis model in ovariectomized rats. The results of this investigation indicate that the model and methods described are quite suitable for screening potential antifungal ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: McRipley RJ,Erhard PJ,Schwind RA,Whitney RR

    更新日期:1979-09-01 00:00:00

  • Acquired common variable hypogammaglobulinaemia and lymphoedema.

    abstract::Two patients with lymphoedema of the legs developed recurrent respiratory infections and were found to have panhypogammaglobulinaemia. The early recognition and treatment of this form of immunity deficiency in patients with lymphoedema is important in order to prevent recurrent infections which could cause pulmonary d...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Lozewicz S,Morris G,Garbett N,Browse N,Slavin B,Cole P

    更新日期:1988-01-01 00:00:00

  • Congenital heart disease in pregnancy.

    abstract::Congenital heart disease is now more prevalent than acquired in pregnancy in the developed world. In pregnancy the fall in systemic vascular resistance and increase in blood volume and cardiac output can cause functional deterioration in certain conditions. A minimally symptomatic woman with good ventricular function,...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: Head CE,Thorne SA

    更新日期:2005-05-01 00:00:00

  • General hospital services for deliberate self-poisoning: an expensive road to nowhere?

    abstract::This study was designed to investigate the clinical and economic aspects of deliberate self-poisoning services in four teaching hospitals in Leeds, Leicester, Manchester and Nottingham. We investigated the management of the current self-harm episode, including direct in-hospital costs, in 456 individuals who presented...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,多中心研究


    authors: Kapur N,House A,Creed F,Feldman E,Friedman T,Guthrie E

    更新日期:1999-10-01 00:00:00

  • Clinical distinction of cerebral haemorrhage and cerebral infarction.

    abstract::The clinical features of 62 cases of computerized axial tomography scan-proved cerebral haemorrhage and 81 cases of cerebral infarction in the carotid territory have been compared in a retrospective case note survey. The clinical features which can help in making the distinction between haemorrhage and infarction at t...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Harrison MJ

    更新日期:1980-09-01 00:00:00

  • The management of thyroid disease in pregnancy.

    abstract::The management of hyperthyroidism and hypothyroidism in pregnancy is discussed and illustrated with appropriate cases. The dangers of the usage of high doses of antithyroid drugs and of propranolol are described. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Edwards OM

    更新日期:1979-05-01 00:00:00

  • Misoprostol does not alter the pharmacokinetics of propranolol.

    abstract::Twelve healthy volunteers took part in a randomised, double-blind, balanced, cross-over study to investigate the effect of misoprostol on the pharmacokinetics of propranolol. The subjects took propranolol 80 mg twice daily by mouth plus either misoprostol 400 micrograms twice daily or placebo by mouth for 14.5 days, f...

    journal_title:Postgraduate medical journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bennett PN,Fenn GC,Notarianni LJ,Lee CE

    更新日期:1991-05-01 00:00:00

  • Tuberculous perforation of the small bowel.

    abstract::Small bowel perforation occurs in up to 2 percent of patients with abdominal tuberculous. Patients present with an acute abdomen. Resection of the diseased segment and 18 months treatment with anti-tuberculosis drugs is recommended. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Aston NO,de Costa AM

    更新日期:1985-03-01 00:00:00

  • Factors associated with high risk of marginal hyperthermia in elderly patients living in an institution.

    abstract::The elderly, the very young, and the sick are known to be adversely affected by high environmental temperatures. In a retrospective open case-note review of 872 patients in a large institution during a hot summer we identified characteristics in the elderly that increase the risk of marginal hyperthermia. Women were m...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Vassallo M,Gera KN,Allen S

    更新日期:1995-04-01 00:00:00

  • Pubic osteomyelitis presenting as irritable hip.

    abstract::Two cases of pubic osteomyelitis presenting as a painful hip are reported. In both cases the diagnosis was delayed by the unusual presentation and by the limited radiological investigation. Pubic osteomyelitis is rare in childhood but should be considered in the differential diagnosis of the 'irritable hip'. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Weinberg JR,Berman L,Dootson G,Mitchell R

    更新日期:1987-04-01 00:00:00

  • Ranitidine compared with cimetidine in the short-term healing of duodenal ulcer.

    abstract::The efficacy of ranitidine (150 mg twice daily) and cimetidine (200 mg three times daily and 400 mg at night) in the short-term healing of duodenal ulcer has been assessed in a randomized controlled trial involving 106 patients. There were 3 drop-outs. Forty-two out of 53 patients (79%) treated with ranitidine had hea...

    journal_title:Postgraduate medical journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lee FI,Fielding JD,Costello FT

    更新日期:1983-02-01 00:00:00

  • Global health training in US obstetrics and gynaecology residency programmes: perspectives of students, residents and programme directors.

    abstract:BACKGROUND:Benefits of exposure to global health training during medical education are well documented and residents' demand for this training is increasing. Despite this, it is offered by few US obstetrics and gynaecology (OBGYN) residency training programmes. OBJECTIVES:To evaluate interest, perceived importance, pr...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Nathan LM,Banks EH,Conroy EM,McGinn AP,Ghartey JP,Wagner SA,Merkatz IR

    更新日期:2015-12-01 00:00:00

  • General practice and social service partnership for better clinical outcomes, patient self efficacy and lifestyle behaviours of diabetic care: randomised control trial of a chronic care model.

    abstract:BACKGROUND:The International Diabetes Attitudes, Wishes, and Needs (DAWN) programmes have shown the existence of a critical gap in self management support and access to the support system. This study aims to evaluate the effectiveness of the diabetes mellitus (DM) self management programme, with partnership between gen...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,随机对照试验


    authors: Lee A,Siu CF,Leung KT,Lau LC,Chan CC,Wong KK

    更新日期:2011-10-01 00:00:00

  • Haemorrhagic breast infarction complicating anticoagulant therapy.

    abstract::Haemorrhagic infarction of the breast induced by anticoagulant therapy is rare and has been infrequently reported in the literature. The following report illustrates such a case in which there was development of massive haemorrhagic infarction of the breast during treatment with nicoumalone for deep venous thrombosis ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Banik S,Brun C

    更新日期:1982-01-01 00:00:00

  • An audit of "do not attempt resuscitation" decisions in two district general hospitals: do current guidelines need changing?

    abstract:INTRODUCTION:Doctors in all specialties are involved in making "do not attempt resuscitation" (DNAR) decisions; this can be a difficult and challenging process. Guidelines exist to provide an ethical and legal framework for the process and documentation of these decisions. OBJECTIVE:To audit the documentation of resus...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,多中心研究


    authors: Harris D,Davies R

    更新日期:2007-02-01 00:00:00

  • Comparison of aortic dissection in Chinese patients with and without Marfan syndrome.

    abstract:BACKGROUND:Aortic dissection is a life-threatening cardiovascular disease with high mortality. Little is known about comparisons of the clinical characteristics or the factors that influence the long-term prognosis of Chinese patients with aortic dissection with and without Marfan syndrome (MFS). METHODS:The authors s...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Linggen G,Lin Z,Xiaohan F,Haiying W,Xianliang Z,Rutai H

    更新日期:2011-05-01 00:00:00

  • Delayed sudden death after ingestion of MCPP and ioxynil: an unusual presentation of hormonal weedkiller intoxication.

    abstract::A patient who died in asystole less than 18 h after ingestion of 'Clovercide Extra', a combination hormonal weedkiller containing ioxynil and 4-chloro-2-methyl phenoxypropionic acid, is described. Previous reports describe coma as an early event following ingestion of these herbicides. In contrast our patient, althoug...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Dickey W,McAleer JJ,Callender ME

    更新日期:1988-09-01 00:00:00

  • Fatal tension pneumoperitoneum due to aerophagy.

    abstract::A case of fetal tension pneumoperitoneum following gastric perforation due to aerophagy is described. Comment is made on the probably pathogenesis. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Hutchinson GH,Alderson DM,Turnberg LA

    更新日期:1980-07-01 00:00:00

  • Testis cancer.

    abstract::Testis cancer is an increasing problem, especially in northern European male populations. However, survival has improved dramatically over one generation. Environmental factors may have a role in the aetiology with high oestrogen concentrations implicated. Testis cancer is subdivided between seminoma and non-seminoma....

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审


    authors: Khan O,Protheroe A

    更新日期:2007-10-01 00:00:00

  • A doctor's experience of resuscitation decision making for older patients: coping with change.

    abstract::There has been a dramatic change in the way that resuscitation decisions are made for older hospital inpatients in the UK. In less than 20 years many geriatric medicine wards have moved from an "opt-in" policy (where the default position is not to provide resuscitation) to a position where resuscitation is widely avai...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Bowker L

    更新日期:2009-11-01 00:00:00

  • Prognostic factors in Wegener's granulomatosis.

    abstract::We analysed data from 64 patients with Wegener's granulomatosis to determine predictor variables of outcome. The mean period of observation after the diagnosis had been established was 3.2 (range 0.1-11.2) years. At the time of diagnosis, 15 (23%) patients had only local symptoms. The disease was generalized to multip...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Briedigkeit L,Kettritz R,Göbel U,Natusch R

    更新日期:1993-11-01 00:00:00

  • Republished paper: Meta-analysis of the effect of comprehensive smoke-free legislation on acute coronary events.

    abstract:OBJECTIVE:To assess the evidence for a reduced risk of acute coronary events following comprehensive smoke-free legislation. METHODS:Two independent systematic reviews were undertaken using PubMed, Embase and Science Direct with no date restrictions imposed. Meta-analysis was undertaken using a random effects model to...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Mackay DF,Irfan MO,Haw S,Pell JP

    更新日期:2011-04-01 00:00:00

  • Troponin T elevation in lobar lung disease.

    abstract::Two patients with a rise in cardiac troponin T (cTnT) concentrations during the course of lobar pneumonia, without any evidence of acute coronary syndrome or renal failure, are presented. The increase in cTnT concentration is considered a highly sensitive marker of cardiac injury, although it may also rise in other co...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章


    authors: Weinberg I,Cukierman T,Chajek-Shaul T

    更新日期:2002-04-01 00:00:00