Misoprostol does not alter the pharmacokinetics of propranolol.

Abstract:

:Twelve healthy volunteers took part in a randomised, double-blind, balanced, cross-over study to investigate the effect of misoprostol on the pharmacokinetics of propranolol. The subjects took propranolol 80 mg twice daily by mouth plus either misoprostol 400 micrograms twice daily or placebo by mouth for 14.5 days, followed by a 2-week washout period, followed by the alternate treatment for 14.5 days. Misoprostol had no significant effect on the t/2, Cmax or AUC of propranolol either after a single dose or at steady state.

journal_name

Postgrad Med J

authors

Bennett PN,Fenn GC,Notarianni LJ,Lee CE

doi

10.1136/pgmj.67.787.455

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

455-7

issue

787

eissn

0032-5473

issn

1469-0756

journal_volume

67

pub_type

临床试验,杂志文章,随机对照试验
  • Recurrent thrombo-embolic episodes: the association of cholangiocarcinoma with antiphospholipid syndrome.

    abstract::Antiphospholipid syndrome is a disorder of recurrent vascular thrombosis, pregnancy loss and thrombocytopenia associated with persistently elevated levels of antiphospholipid antibodies. It was first described in a group of patients with systemic lupus erythematosus but has since been associated with a wide range of c...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.75.879.45

    authors: Samadian S,Estcourt L

    更新日期:1999-01-01 00:00:00

  • Occupation and gastric cancer.

    abstract::Gastric cancer is a cause of significant morbidity and mortality. There are several risk factors, with occupation emerging as one of these. There is considerable evidence that occupations in coal and tin mining, metal processing, particularly steel and iron, and rubber manufacturing industries lead to an increased ris...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pmj.79.931.252

    authors: Raj A,Mayberry JF,Podas T

    更新日期:2003-05-01 00:00:00

  • Role of imaging in the diagnosis of acute bacterial meningitis and its complications.

    abstract::Acute bacterial meningitis is a common neurological emergency and a leading cause of death and neurological disability worldwide. Diagnosis is based on clinical and microbiological findings with neuroimaging in the form of CT reserved for those with specific adverse clinical features or when an underlying cause such a...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2010.097022

    authors: Hughes DC,Raghavan A,Mordekar SR,Griffiths PD,Connolly DJ

    更新日期:2010-08-01 00:00:00

  • Congestive cardiomyopathy and endobronchial granulomas as manifestations of Churg-Strauss syndrome.

    abstract::Churg-Strauss syndrome is a systemic vasculitis. Its most frequent complications are heart diseases and asthma. Usually, cardiological manifestations are pericarditis, cardiac failure and myocardial infarction. Endobronchial granulomas identified by bronchoscopy are unusual. We present the case of a man with congestiv...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.71.836.365

    authors: Alvarez-Sala R,Prados C,Armada E,Del Arco A,Villamor J

    更新日期:1995-06-01 00:00:00

  • Colonic ulcers in propylthiouracil induced vasculitis with secondary antiphospholipid syndrome.

    abstract::A 48 year old white woman was admitted to the hospital because of several bouts of migratory polyarthritis, weight loss, fever, and abdominal pain over a period of 15 months. She had been taking propylthiouracil 100 mg daily for three years for hyperthyroidism treatment. A test for antineutrophil cytoplasmic autoantib...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2004.026104

    authors: Gaburri PD,Chebli JM,Attalla A,Pereira CM,Bonfante HL,Junior EV,Gaburri AK

    更新日期:2005-05-01 00:00:00

  • Multiple strokes after initiation of steroid therapy in giant cell arteritis.

    abstract::We report the case of a 66 year old woman with clinical manifestations of giant-cell arteritis, positive temporal artery biopsy and excellent response to prednisone, who developed massive cerebral infarcts after 5 days of treatment. Computed tomographic and magnetic resonance imaging scans revealed multiple infarcts i...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.70.821.228

    authors: Collazos J,García-Moncó C,Martín A,Rodriguez J,Gómez MA

    更新日期:1994-03-01 00:00:00

  • Intracoronary ultrasound.

    abstract::Although contrast angiography is important in the diagnosis and treatment of atherosclerotic disease, it does have limitations. Intracoronary ultrasound more accurately assesses the amount of atherosclerosis and has given us new insights into the pathophysiology of coronary plaque accumulation and remodelling. It also...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.74.874.468

    authors: Hammond C,Causer JP,Perry RA

    更新日期:1998-08-01 00:00:00

  • Unravelling the helix--a physician's guide to spiral computed tomography.

    abstract::The introduction of spiral technology to computed tomography (CT) scanners in the late 1980s has revolutionised the field of CT. Spiral CT offers definite practical benefits over conventional scanners and has expanded the role of CT through the development of new scanning techniques. CT scanning now rivals magnetic re...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.74.868.96

    authors: Kearney SE,Garvey CJ

    更新日期:1998-02-01 00:00:00

  • Is antibiotic resistance a problem? A practical guide for hospital clinicians.

    abstract::Antibiotic resistance is an important concern for patients, physicians, healthcare managers, and policymakers. Inappropriate antimicrobial prescribing fuels the evolution of resistance, while poor basic hygiene facilitates the spread of resistant microbes between patients and healthcare staff. The development of infec...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2005.035113

    authors: Barlow G,Nathwani D

    更新日期:2005-11-01 00:00:00

  • Influenza vaccination in the elderly.

    abstract::There is overwhelming evidence for the clinical efficacy of the influenza vaccine, especially in the elderly with chronic disease, reducing mortality and hospital admissions. There is also evidence to suggest that the influenza vaccine may be beneficial in the healthy elderly. There is some evidence to suggest that th...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.72.848.339

    authors: Morgan R,King D

    更新日期:1996-06-01 00:00:00

  • Knowledge and attitudes of breast self examination in a group of women in Shiraz, southern Iran.

    abstract:BACKGROUND:Breast cancer is the most common cause of cancer related deaths among women worldwide. The disease in women occurs at a younger age in Iran than in western communities. OBJECTIVE:To determine the practice of breast self examination (BSE) among 25-54-year-old women in Shiraz, southern Iran. METHODS:Using a ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2008.072678

    authors: Simi A,Yadollahie M,Habibzadeh F

    更新日期:2009-06-01 00:00:00

  • Lobar collapse demystified: the chest radiograph with CT correlation.

    abstract::Collapse of a lobe of a lung is an important indicator of a range of conditions, including malignancy. Clinical symptoms and signs may suggest a diagnosis of lobar collapse; however, it is often diagnosed, and always needs to be confirmed, with radiological examination. The radiological signs may be subtle, difficult ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/postgradmedj-2011-130213

    authors: Mullett R,Jain A,Kotugodella S,Curtis J

    更新日期:2012-06-01 00:00:00

  • Abdominal epilepsy misdiagnosed as psychogenic pain.

    abstract::The authors present the case report of a child with abdominal epilepsy who had suffered from abdominal pain for several months under the label of psychogenic pain. The important historical clues were pallor and cold sweating during the paroxysm, followed by lethargy and prolonged sleep. An abnormal electroencephalogra...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.64.750.281

    authors: Singhi PD,Kaur S

    更新日期:1988-04-01 00:00:00

  • Tuberculous perforation of the small bowel.

    abstract::Small bowel perforation occurs in up to 2 percent of patients with abdominal tuberculous. Patients present with an acute abdomen. Resection of the diseased segment and 18 months treatment with anti-tuberculosis drugs is recommended. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.61.713.251

    authors: Aston NO,de Costa AM

    更新日期:1985-03-01 00:00:00

  • Localisation of the cricothyroid membrane by digital palpation in the emergency department.

    abstract:INTRODUCTION:A surgical approach to airway management may be essential in situations of difficult or failed airway, where immediate airway access is needed to provide oxygenation. However, the procedure is uncommonly performed and expertise among emergency clinicians may be limited. OBJECTIVES:The aim of this study wa...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2018-135828

    authors: Alshareef H,Al Saawi A,Almazroua F,Alyami H,Reilly GO,Mitra B

    更新日期:2018-08-01 00:00:00

  • Diabetes insipidus complicating myelofibrosis.

    abstract::A 68 year old man developed cranial diabetes insipidus 3 years after the diagnosis of myelofibrosis, coincident with a marked increase in nucleated cell count. No mass lesion was demonstrable on computed tomographic or magnetic resonance imaging. It is suggested that hypothalamic damage was caused by local infiltratio...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.65.759.36

    authors: Dornan TL,Gillett G,Jones PA,Jeffcoate WJ

    更新日期:1989-01-01 00:00:00

  • Primary nongestational choriocarcinoma of the ovary.

    abstract::Primary choriocarcinoma of the ovary arising, presumably, from a germ cell is extremely rare. The patient, a 16 year old girl who presented with dysuria and frequency of micturition developed fatal haemoperitoneum due to rupture of a pure primary nongestational ovarian choriocarcinoma. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.61.718.757

    authors: Raju GC,Woo J,Marchack D,Naraynsingh V

    更新日期:1985-08-01 00:00:00

  • The clinical value of Haemoccult and Fecatwin in the detection of colorectal neoplasia in hospital and general practice patients.

    abstract::Four hundred and fifty asymptomatic general practice patients and 330 hospital inpatients had their stools tested for occult blood with the Haemoccult and Fecatwin methods. In general practice, 9/64 (14%) of patients with a positive result had a colonic neoplasm (three carcinomas, one Dukes' Stage A, two Dukes' Stage ...

    journal_title:Postgraduate medical journal

    pub_type: 临床试验,杂志文章

    doi:10.1136/pgmj.61.718.701

    authors: Barrison IG,Parkins RA

    更新日期:1985-08-01 00:00:00

  • How much can elderly patients tell us about their medications?

    abstract::Two hundred and sixty one patients attending a geriatric service were asked to give details of their usual medications without reference to drug bottles or written lists. Recall was tested in 4 categories: name of drugs, drug dosage, frequency of administration, and reason for the drug being prescribed. Drug recall wa...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.66.772.116

    authors: al Mahdy H,Seymour DG

    更新日期:1990-02-01 00:00:00

  • An unusual cause for a colonic stricture: a case of Mycobacterium xenopi mimicking malignancy.

    abstract::Colonic strictures are very common and are a frequent finding on double contrast barium examination; they very often reflect the presence of malignancy, diverticular disease, ischaemia, inflammatory bowel disease, and rarely mycobacterial disease. A case of mycobacterial disease mimicking malignancy is presented; this...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:

    authors: Rees JR,Longstaff A,Rigby HL,Smith DL,Dixon AR

    更新日期:2003-12-01 00:00:00

  • Grit and burnout in UK doctors: a cross-sectional study across specialties and stages of training.

    abstract:PURPOSE OF THE STUDY:Grit is characterised by the ability to persevere during difficulties and maintain a sustained effort over an extended period of time. Throughout their careers, doctors will experience many periods of stress and difficulty. This may result in burnout, defined by the presence of exhaustion and disen...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,多中心研究

    doi:10.1136/postgradmedj-2015-133919

    authors: Halliday L,Walker A,Vig S,Hines J,Brecknell J

    更新日期:2017-07-01 00:00:00

  • Acute haemodynamic effects of endralazine in patients with coronary artery disease and stable angina pectoris.

    abstract::The acute haemodynamic effects of endralazine, a new hydralazine-like vasodilating agent, were studied in 6 patients with stable angina pectoris and proven coronary artery disease. Twenty minutes after intravenous administration of 5 mg endralazine heart rate and cardiac index increase, while mean arterial blood press...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:

    authors: van der Wall EE,de Feyter PJ,Res JC,Roos JP,van Engelen CL

    更新日期:1983-01-01 00:00:00

  • The prevalence of potentially inappropriate medication prescribing in elderly patients with chronic kidney disease.

    abstract:INTRODUCTION:Potentially inappropriate medication (PIM) prescribing is a global problem. Limited data are available on the prevalence of PIMs in elderly patients with chronic kidney disease (CKD). We examined the PIM prevalence in elderly patients with CKD, the most common drugs implicated and the levels of polypharmac...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2012-130889

    authors: Jones SA,Bhandari S

    更新日期:2013-05-01 00:00:00

  • Barriers to physical activity in patients with diabetes.

    abstract:PURPOSE:Two questions were addressed: (1) How much physical activity do patients with diabetes perform? (2) What are the perceived factors that prevent patients from doing more physical activity? RESEARCH DESIGN AND METHODS:Interview based questionnaires were distributed to consecutive patients attending the Diabetes ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2003.010553

    authors: Thomas N,Alder E,Leese GP

    更新日期:2004-05-01 00:00:00

  • Idiopathic sclerosing peritonitis.

    abstract::A girl of 12 years old presented with acute small bowel obstruction nine weeks after an uncomplicated appendicectomy. The obstruction was found to be due to the development of sclerosing peritonitis. Previous reports of this rare condition have suggested that it is predominantly found in adolescent girls residing in s...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.61.719.841

    authors: Dehn TC,Lucas MG,Wood RF

    更新日期:1985-09-01 00:00:00

  • Digoxin: its role in contemporary medicine.

    abstract::Digoxin has been a key therapeutic for heart failure and atrial tachyarrhythmias for over 200 years following Withering's groundbreaking work depicting the therapeutic benefit of the common botanical foxglove in his 1785 monograph. The use of digoxin preceded any randomised evidence or even basic understanding of its ...

    journal_title:Postgraduate medical journal

    pub_type: 历史文章,杂志文章,评审

    doi:10.1136/postgradmedj-2014-132937

    authors: Stucky MA,Goldberger ZD

    更新日期:2015-09-01 00:00:00

  • Influence of nutrition in childhood on the origins of coronary heart disease.

    abstract::Both the quality and the quantity of food ingested are relevant to the genesis of risk factors for coronary heart disease and the two are inseparable. Nevertheless they have a major common pathway through hypertension, which may well be the most important consequence of a high-protein, high-carbohydrate, high-fat, hig...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.54.629.171

    authors: Brook CG

    更新日期:1978-03-01 00:00:00

  • Clinical distinction of cerebral haemorrhage and cerebral infarction.

    abstract::The clinical features of 62 cases of computerized axial tomography scan-proved cerebral haemorrhage and 81 cases of cerebral infarction in the carotid territory have been compared in a retrospective case note survey. The clinical features which can help in making the distinction between haemorrhage and infarction at t...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.56.659.629

    authors: Harrison MJ

    更新日期:1980-09-01 00:00:00

  • Non-vitamin K antagonist oral anticoagulants (NOACs): clinical evidence and therapeutic considerations.

    abstract::Warfarin, a vitamin K antagonist, is the most widely used oral anticoagulant in the world. It is cheap and effective, but its use is limited in many patients by unpredictable levels of anticoagulation, which increases the risk of thromboembolic or haemorrhagic complications. It also requires regular blood monitoring a...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/postgradmedj-2014-132605

    authors: Saraf K,Morris PD,Garg P,Sheridan P,Storey R

    更新日期:2014-09-01 00:00:00

  • Elevated serum parathyroid hormone related protein and 1,25-dihydroxycholecalciferol in hypercalcaemia associated with adult T-cell leukaemia-lymphoma.

    abstract::Hypercalcaemia occurs in up to 80% of patients with adult T-cell leukaemia-lymphoma (ATLL) associated with human T-cell leukaemia virus-1 infection. Elevated serum levels of 1,25-dihydroxycholecalciferol, implicated in the pathogenesis of hypercalcaemia in lymphoma, and of parathyroid hormone-related protein (PTHrP), ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.68.803.753

    authors: Johnston SR,Hammond PJ

    更新日期:1992-09-01 00:00:00