Protective Effects of Aqueous Extracts of Flos lonicerae Japonicae against Hydroquinone-Induced Toxicity in Hepatic L02 Cells.

abstract：:Stem cells derived from elderly donors or harvested by repeated subculture exhibit a marked decrease in proliferative capacity and multipotency, which not only compromises their therapeutic potential but also raises safety concerns for regenerative medicine. NANOG-a well-known core transcription factor-plays an import...

journal_title：Oxidative medicine and cellular longevity

authors： Liu F,Shi J,Zhang Y,Lian A,Han X,Zuo K,Liu M,Zheng T,Zou F,Liu X,Jin M,Mu Y,Li G,Su G,Liu J

更新日期：2019-12-04 00:00:00

abstract：:The present study aims to explore the protective effect of human bone marrow mesenchymal stem cells (hBMSCs) on radiation-induced aortic injury (RIAI). hBMSCs were isolated and cultured from human bone marrow. Male C57/BL mice were irradiated with a dose of 18-Gy 6MV X-ray and randomly treated with either vehicle or h...

journal_title：Oxidative medicine and cellular longevity

authors： Shen Y,Jiang X,Meng L,Xia C,Zhang L,Xin Y

更新日期：2018-02-28 00:00:00

abstract：:Reactive oxygen species (ROS) are derived from the metabolism of oxygen and are traditionally viewed as toxic byproducts that cause damage to biomolecules. It is now becoming widely acknowledged that ROS are key modulators in a variety of biological processes and pathological states. ROS mediate key signaling transduc...

journal_title：Oxidative medicine and cellular longevity

authors： Zhou Y,Yan H,Guo M,Zhu J,Xiao Q,Zhang L

更新日期：2013-01-01 00:00:00

abstract：:Mitochondria are important bioenergetic and signalling hubs critical for myriad cellular functions and homeostasis. Dysfunction in mitochondria is a central theme in aging and diseases. Mitophagy, a process whereby damaged mitochondria are selectively removed by autophagy, plays a key homeostatic role in mitochondrial...

journal_title：Oxidative medicine and cellular longevity

authors： Tan S,Wong E

更新日期：2017-01-01 00:00:00

abstract：:Pneumococcal meningitis is associated with a significant mortality rate and neurologic sequelae. The animals received either 10 μL of saline or a S. pneumoniae suspension and were randomized into different groups: sham: placebo with dexamethasone 0.7 mg/kg/1 day; placebo with dexamethasone 0.2 mg/kg/7 days; meningitis...

journal_title：Oxidative medicine and cellular longevity

authors： Barichello T,Santos AL,Silvestre C,Generoso JS,Cipriano AL,Petronilho F,Dal-Pizzol F,Comim CM,Quevedo J

更新日期：2011-01-01 00:00:00

abstract：:Due to the high biotolerance, favourable mechanical properties, and osseointegration ability, titanium is the basic biomaterial used in maxillofacial surgery. The passive layer of titanium dioxide on the surface of the implant effectively provides anticorrosive properties, but it can be damaged, resulting in the relea...

journal_title：Oxidative medicine and cellular longevity

authors： Borys J,Maciejczyk M,Antonowicz B,Krętowski A,Waszkiel D,Bortnik P,Czarniecka-Bargłowska K,Kocisz M,Szulimowska J,Czajkowski M,Waszkiewicz N,Zalewska A

更新日期：2018-06-14 00:00:00

abstract：:The neutrophil elastase inhibitor sivelestat (ONO-5046) possesses unknown mechanisms of cardioprotection when infused following global ischemia, even in the absence of neutrophils. Since myocardial ischemia-reperfusion injury is strongly associated with endothelial dysfunction and reactive oxygen species (ROS) generat...

journal_title：Oxidative medicine and cellular longevity

authors： Aune SE,Yeh ST,Kuppusamy P,Kuppusamy ML,Khan M,Angelos MG

更新日期：2013-01-01 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase IV (CaMKIV) is an upstream regulator of CaMKK-CaMKIV signaling cascade that activates various transcription factors, thereby regulating several cellular activities including, neuronal communication and immune response. Owing to the abnormal expression in cancer and neurodege...

journal_title：Oxidative medicine and cellular longevity

authors： Gupta P,Khan S,Fakhar Z,Hussain A,Rehman MT,AlAjmi MF,Islam A,Ahmad F,Hassan MI

更新日期：2020-07-16 00:00:00

abstract：:A number of drugs have been withdrawn from the market or severely restricted in their use because of unexpected toxicities that become apparent only after the launch of new drug entities. Circumstantial evidence suggests that, in most cases, reactive metabolites are responsible for these unexpected toxicities. In this...

journal_title：Oxidative medicine and cellular longevity

authors： Attia SM

更新日期：2010-07-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) (grade IV astrocytoma) has been assumed to be the most fatal type of glioma with low survival and high recurrence rates, even after prompt surgical removal and aggressive courses of treatment. Transcriptional reprogramming to stem cell-like state could explain some of the deregulated mole...

journal_title：Oxidative medicine and cellular longevity

authors： Fawzy MS,Badran DI,Al Ageeli E,Al-Qahtani SAM,Alghamdi SA,Helal GM,Toraih EA

更新日期：2018-03-21 00:00:00

abstract：:Known for centuries throughout the world, Plantago species have long been used as traditional herbal remedies for many diseases related to inflammatory conditions of the skin, respiratory and digestive tract, or even malignancy. This study is aimed first at investigating the in vitro antioxidant and regenerative effec...

journal_title：Oxidative medicine and cellular longevity

authors： Farcaș AD,Moț AC,Pârvu AE,Toma VA,Popa MA,Mihai MC,Sevastre B,Roman I,Vlase L,Pârvu M

更新日期：2019-06-02 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder characterised by impairments in the cognitive domains associated with orientation, recording, and memory. This pathology results from an abnormal deposition of the β-amyloid (Aβ) peptide and the intracellular accumulation of neurofibrillary tangles. Mitochondria...

journal_title：Oxidative medicine and cellular longevity

authors： Dos Santos SM,Romeiro CFR,Rodrigues CA,Cerqueira ARL,Monteiro MC

更新日期：2019-11-30 00:00:00

abstract：:Curcumin was found to be beneficial in treating several skin pathologies and diseases, providing antioxidant protection due to its reducing properties and its electrophilic properties (the ability to activate the Nrf2 pathway and induce phase II cytoprotective enzymes). Nevertheless, clinical applications of curcumin ...

journal_title：Oxidative medicine and cellular longevity

authors： Ben Yehuda Greenwald M,Frušić-Zlotkin M,Soroka Y,Ben Sasson S,Bitton R,Bianco-Peled H,Kohen R

更新日期：2017-01-01 00:00:00

abstract：:Neutrophils play a critical role in the initiation and maintenance of intestinal inflammation. However, conventional neutrophil-targeted therapies can impair normal host defense. Tanshinone IIA has been recently revealed to act directly on neutrophils. Hence, we aimed at investigating whether Tanshinone IIA can protec...

journal_title：Oxidative medicine and cellular longevity

authors： Liu X,He H,Huang T,Lei Z,Liu F,An G,Wen T

更新日期：2016-01-01 00:00:00

abstract：:Escherichia coli (E. coli) is one of pathogens causing nosocomial pneumonia and could induce pulmonary excessive apoptosis. Although much has been learned about metabolic diseases induced by obesity, the information linking bacterial pneumonia to obesity is limited. Accordingly, we investigated the apoptosis of normal...

journal_title：Oxidative medicine and cellular longevity

authors： Wang F,Zuo Z,Yang Z,Chen K,Fang J,Cui H,Shu G,Zhou Y,Geng Y,Ouyang P

更新日期：2019-10-22 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease that threatens human health, and present therapies remain limited due to the lack of effective drugs. Lipid metabolic disturbance and oxidative stress have strong links to the development of NAFLD, while autophagy was generally accepted as a key regu...

journal_title：Oxidative medicine and cellular longevity

authors： Chu Q,Zhang S,Chen M,Han W,Jia R,Chen W,Zheng X

更新日期：2019-02-25 00:00:00

abstract：Aims:The goal of this study was to evaluate the effects of long-term (16 weeks) administration of angiotensin (1-7) [A(1-7)] on kidney function in db/db mice and to identify the protective mechanisms of this therapy. Methods:db/db mice and heterozygous controls were treated with A(1-7) or vehicle daily, subcutaneously...

journal_title：Oxidative medicine and cellular longevity

authors： Papinska AM,Rodgers KE

更新日期：2018-10-23 00:00:00

abstract：:As one of the major risks for urolithiasis, hyperoxaluria can be caused by genetic defect or dietary intake. And high oxalate induced renal epithelial cells injury is related to oxidative stress and mitochondrial dysfunction. Here, we investigated whether MitoTEMPO, a mitochondria-targeted antioxidant, could protect a...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang J,Wang Q,Xu C,Lu Y,Hu H,Qin B,Wang Y,He D,Li C,Yu X,Wang S,Liu J

更新日期：2017-01-01 00:00:00

abstract：:Dedifferentiated vascular smooth muscle cells (VSMCs) are phenotypically modulated from the contractile state to the active synthetic state in the vessel wall. In this study, we investigated the effects of resveratrol on phenotype modulation by dedifferentiation and the intracellular signal transduction pathways of pl...

journal_title：Oxidative medicine and cellular longevity

authors： Lee MH,Kwon BJ,Seo HJ,Yoo KE,Kim MS,Koo MA,Park JC

更新日期：2014-01-01 00:00:00

abstract：:The influence of a water-soluble [60] fullerene derivative containing five residues of 3-phenylpropionic acid and a chlorine addend appended to the carbon cage (F-828) on serum-starving human embryo lung diploid fibroblasts (HELFs) was studied. Serum deprivation evokes oxidative stress in HELFs. Cultivation of serum-s...

journal_title：Oxidative medicine and cellular longevity

authors： Ershova ES,Sergeeva VA,Tabakov VJ,Kameneva LA,Porokhovnik LN,Voronov II,Khakina EA,Troshin PA,Kutsev SI,Veiko NN,Kostyuk SV

更新日期：2016-01-01 00:00:00

abstract：:Non-thermal plasma (NTP), an ionized gas generated at ambient pressure and temperature, has been an emerging technology for medical applications. Through controlled delivery of reactive oxygen and nitrogen species (ROS/RNS), NTP can elicit hormetic cellular responses, thus stimulating broad therapeutic effects. To ena...

journal_title：Oxidative medicine and cellular longevity

authors： Lin A,Biscop E,Breen C,Butler SJ,Smits E,Bogaerts A

更新日期：2020-12-03 00:00:00

abstract：:3-Morpholinosydnonimine (SIN-1) is used as a donor of peroxynitrite (ONOO(-)) in various studies. We demonstrated, however, that, the cell-culture medium remains cytotoxic to PC12 cells even after almost complete SIN-1 decomposition, suggesting that reaction product(s) in the medium, rather than ONOO(-), exert cytotox...

journal_title：Oxidative medicine and cellular longevity

authors： Shirai K,Okada T,Konishi K,Murata H,Akashi S,Sugawara F,Watanabe N,Arai T

更新日期：2012-01-01 00:00:00

abstract：:We have hypothesized that the adaptive response to low doses of ionizing radiation (IR) is mediated by oxidized cell-free DNA (cfDNA) fragments. Here, we summarize our experimental evidence for this model. Studies involving measurements of ROS, expression of the NOX (superoxide radical production), induction of apopto...

journal_title：Oxidative medicine and cellular longevity

authors： Sergeeva VA,Ershova ES,Veiko NN,Malinovskaya EM,Kalyanov AA,Kameneva LV,Stukalov SV,Dolgikh OA,Konkova MS,Ermakov AV,Veiko VP,Izhevskaya VL,Kutsev SI,Kostyuk SV

更新日期：2017-01-01 00:00:00

abstract：:Several of the most prevalent etiological factors which contribute towards global death rates are associated with cardiovascular diseases (CVDs), which include a range of conditions such as angina, rheumatic heart disease, and venous thrombosis. Extensive research has been conducted into the role played by oxidative s...

journal_title：Oxidative medicine and cellular longevity

authors： Chen S,Jiang H,Peng H,Wu X,Fang J

更新日期：2017-01-01 00:00:00

abstract：:Virulence of enterohemorrhagic Escherichia coli (EHEC) strains depends on production of Shiga toxins. These toxins are encoded in genomes of lambdoid bacteriophages (Shiga toxin-converting phages), present in EHEC cells as prophages. The genes coding for Shiga toxins are silent in lysogenic bacteria, and prophage indu...

journal_title：Oxidative medicine and cellular longevity

authors： Licznerska K,Nejman-Faleńczyk B,Bloch S,Dydecka A,Topka G,Gąsior T,Węgrzyn A,Węgrzyn G

更新日期：2016-01-01 00:00:00

abstract：:Glycaemic control is the main focus of managing diabetes and its complications. Hyperglycaemia induces oxidative stress favouring cellular damage and subsequent diabetic complications. The present study was conducted to compare the plasma total antioxidant capacity (TAC) and individual antioxidant marker antioxidant s...

journal_title：Oxidative medicine and cellular longevity

authors： Gunawardena HP,Silva R,Sivakanesan R,Ranasinghe P,Katulanda P

更新日期：2019-08-05 00:00:00

abstract：:Some iron chelators display significant anticancer activity that may involve ferritin degradation either in proteasomes or in lysosomes, and the latter might involve ferritinophagy with a period. However, the correlation of ferritinophagy with anticancer activity of iron chelator was not fully determined. Revealing th...

journal_title：Oxidative medicine and cellular longevity

authors： Huang T,Sun Y,Li Y,Wang T,Fu Y,Li C,Li C

更新日期：2018-08-05 00:00:00

abstract：:Postmenopausal osteoporosis (PO) is a major public health issue which affects a large fraction of elderly women. Emerging in vitro evidence suggests a central role of oxidative stress (OxS) in postmenopausal osteoporosis (PO) development. Contrariwise, the human studies on this topic are still scarce and inconclusive....

journal_title：Oxidative medicine and cellular longevity

authors： Cervellati C,Romani A,Cremonini E,Bergamini CM,Fila E,Squerzanti M,Greco P,Massari L,Bonaccorsi G

更新日期：2016-01-01 00:00:00

abstract：:We investigated the effect of high-frequency electromagnetic fields (HF-EMFs) and 17-β-estradiol on connexins (Cxs), integrins (Ints), and estrogen receptor (ER) expression, as well as on ultrastructure of trophoblast-derived HTR-8/SVneo cells. HF-EMF, 17-β-estradiol, and their combination induced an increase of Cx40 ...

journal_title：Oxidative medicine and cellular longevity

authors： Cervellati F,Valacchi G,Lunghi L,Fabbri E,Valbonesi P,Marci R,Biondi C,Vesce F

更新日期：2013-01-01 00:00:00

abstract：:In recent decades, localized tissue oxidative stress has been implicated as a key component in the development of diabetic retinopathy (DR). Increasing evidence shows that oxidative stress caused by diabetes-induced metabolic abnormalities is the most common mechanism associated with the pathogenesis of DR for both ty...

journal_title：Oxidative medicine and cellular longevity

authors： Wu Y,Tang L,Chen B

更新日期：2014-01-01 00:00:00