Pyrethroid pesticide exposure and hematological cancer: epidemiological, biological and molecular evidence.

Abstract:

:Pyrethroid insecticides are commonly used worldwide. The chronic effects of these compounds are of concern given that epidemiological studies have suggested an association with hematological cancer, particularly in children. However, the biological evidence at molecular and cellular levels is limited. A review on the molecular and cellular effects of pyrethroids is helpful to guide the study of the biological plausibility of the association of pyrethroids with hematological cancer. We reviewed studies suggesting that pyrethroids are genotoxic, induce genetic rearrangements, alter gene expression and modify DNA. All of these biological modifications could potentially contribute to the carcinogenic process in hematopoietic cells.

journal_name

Rev Environ Health

authors

Navarrete-Meneses MDP,Pérez-Vera P

doi

10.1515/reveh-2018-0070

subject

Has Abstract

pub_date

2019-06-26 00:00:00

pages

197-210

issue

2

eissn

0048-7554

issn

2191-0308

pii

/j/reveh.ahead-of-print/reveh-2018-0070/reveh-2018

journal_volume

34

pub_type

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