Abstract:
:Growing evidence indicates that autism spectrum disorder (ASD) is a neuropsychological disconnection syndrome that can be analyzed using various complex network metrics used as pathology biomarkers. Recently, community detection and analysis rooted in the complex network and graph theories have been introduced to investigate the changes in resting-state functional network community structure under neurological pathologies. However, the potential of hidden patterns in the modular organization of networks derived from resting-state functional magnetic resonance imaging to predict brain pathology has never been investigated. In this study, we present a novel analysis technique to identify alterations in community patterns in functional networks under ASD. In addition, we design machine learning classifiers to predict the clinical class of patients with ASD and controls by using only community pattern quality metrics as features. Analyses conducted on six publicly available datasets from 235 subjects, including patients with ASD and age-matched controls revealed that the modular structure is significantly disturbed in patients with ASD. Machine learning algorithms showed that the predictive power of our five metrics is relatively high (~85.16% peak accuracy for in-site data and ~75.00% peak accuracy for multisite data). These results lend further credence to the dysconnectivity theory of this pathology.
journal_name
Front Hum Neuroscijournal_title
Frontiers in human neuroscienceauthors
Song Y,Epalle TM,Lu Hdoi
10.3389/fnhum.2019.00203subject
Has Abstractpub_date
2019-06-14 00:00:00pages
203issn
1662-5161journal_volume
13pub_type
杂志文章abstract::An advantage of rehabilitation administered on computers or tablets is that the tasks can be self-administered and the cueing required to complete the tasks can be monitored. Though there are many types of cueing, few studies have examined how participants' response to rehabilitation is influenced by self-administered...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2017.00007
更新日期:2017-02-01 00:00:00
abstract::Indirect speech acts-responding "I forgot to wear my watch today" to someone who asked for the time-are ubiquitous in daily conversation, but are understudied in current neurobiological models of language. To comprehend an indirect speech act like this one, listeners must not only decode the lexical-semantic content o...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2020.598131
更新日期:2021-01-14 00:00:00
abstract::[This corrects the article on p. 673 in vol. 8, PMID: 25221500.]. ...
journal_title:Frontiers in human neuroscience
pub_type: 已发布勘误
doi:10.3389/fnhum.2014.00923
更新日期:2014-11-14 00:00:00
abstract::The error-related and feedback-related negativities (ERN and FRN) represent negative event-related potentials associated with the processing of errors and (negative) response outcomes. The neuronal source of these components is considered to be in the anterior cingulate cortex (ACC). Monitoring one's own behavior and ...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2012.00135
更新日期:2012-05-17 00:00:00
abstract::Previous electrophysiological studies of automatic language processing revealed early (100-200 ms) reflections of access to lexical characteristics of speech signal using the so-called mismatch negativity (MMN), a negative ERP deflection elicited by infrequent irregularities in unattended repetitive auditory stimulati...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2013.00421
更新日期:2013-08-09 00:00:00
abstract::[This corrects the article on p. 622 in vol. 11, PMID: 29311877.]. ...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章,已发布勘误
doi:10.3389/fnhum.2018.00012
更新日期:2018-01-30 00:00:00
abstract::Sensory feedback is critical for motor learning, and thus to neurorehabilitation after stroke. Whether enhancing sensory feedback by applying excitatory repetitive transcranial magnetic stimulation (rTMS) over the ipsilesional primary sensory cortex (IL-S1) might enhance motor learning in chronic stroke has yet to be ...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2014.00143
更新日期:2014-03-21 00:00:00
abstract::Behavioral findings in several strategic games indicate that people punish others if they think they are being treated unequally, even at the cost of minimizing their own material payoff. We investigated the primary driving force behind such non-self-regarding behavior, so-called, altruistic cooperation. In all of our...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2013.00252
更新日期:2013-06-07 00:00:00
abstract::[This corrects the article on p. 3 in vol. 9, PMID: 25674060.]. ...
journal_title:Frontiers in human neuroscience
pub_type: 已发布勘误
doi:10.3389/fnhum.2015.00172
更新日期:2015-03-26 00:00:00
abstract::Breakfast consumption is associated with positive outcomes for diet quality, micronutrient intake, weight status and lifestyle factors. Breakfast has been suggested to positively affect learning in children in terms of behavior, cognitive, and school performance. However, these assertions are largely based on evidence...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2013.00425
更新日期:2013-08-08 00:00:00
abstract::Face perception is mediated by a distributed brain network comprised of the core system at occipito-temporal areas and the extended system at other relevant brain areas involving bilateral hemispheres. In this study we explored how the brain connectivity changes over the time for face-sensitive processing. We investig...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2015.00662
更新日期:2015-12-08 00:00:00
abstract::Gait is one of the fundamental behaviors we use to interact with the world. The functionality of the locomotor system is thus related to enriching interactions with our environment. The posterior parietal cortex (PPC) has been found to contribute to motor adaptation during both visuomotor and postural adaptation tasks...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2020.581026
更新日期:2020-11-05 00:00:00
abstract::The prospect of enhancing cognition is undoubtedly among the most exciting research questions currently bridging psychology, neuroscience, and evidence-based medicine. Yet, convincing claims in this line of work stem from designs that are prone to several shortcomings, thus threatening the credibility of training-indu...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2016.00153
更新日期:2016-04-14 00:00:00
abstract::Recent statistics have shown that the main difficulty in detecting alcoholism is the unreliability of the information presented by patients with alcoholism; this factor confusing the early diagnosis and it can reduce the effectiveness of treatment. However, electroencephalogram (EEG) exams can provide more reliable da...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2020.00365
更新日期:2020-09-18 00:00:00
abstract::Contemporary philosophical and neurocognitive studies of the self have dissociated two distinct types of self-awareness: a "narrative" self-awareness (NS) weaving together episodic memory, future planning and self-evaluation into a coherent self-narrative and identity, and a "minimal" self-awareness (MS) focused on pr...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2013.00582
更新日期:2013-09-24 00:00:00
abstract::Inter- and intra-subject variability of the motor evoked potentials (MEPs) to TMS is a well-known phenomenon. Although a possible link between this variability and ongoing brain oscillations was demonstrated, the results of the studies are not consistent with each other. Exploring this topic further is important since...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2016.00504
更新日期:2016-10-07 00:00:00
abstract::Holding biological motion (BM), the movements of animate entities, in working memory (WM) is important to our daily life activities. However, the neural substrates underlying the WM processing of BM remain largely unknown. Employing the functional magnetic resonance imaging (fMRI) technique, the current study directly...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2016.00251
更新日期:2016-06-01 00:00:00
abstract::[This corrects the article DOI: 10.3389/fnhum.2015.00098.]. ...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章,已发布勘误
doi:10.3389/fnhum.2019.00125
更新日期:2019-04-09 00:00:00
abstract::Neuroimaging combined with transcranial magnetic stimulation (TMS) to primary motor cortex (M1) is an emerging technique that can examine motor-system functionality through evoked activity. However, because sensory afferents from twitching muscles are widely represented in motor areas the amount of evoked activity dir...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2013.00554
更新日期:2013-09-17 00:00:00
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journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2014.00901
更新日期:2014-11-07 00:00:00
abstract::Mirror visual feedback (MVF) is a promising approach to enhance motor performance without training in healthy adults as well as in patients with focal brain lesions. There is preliminary evidence that a functional modulation within and between primary motor cortices as assessed with transcranial magnetic stimulation (...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2017.00054
更新日期:2017-02-06 00:00:00
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journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2020.585086
更新日期:2020-10-22 00:00:00
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journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2013.00608
更新日期:2013-10-10 00:00:00
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journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2018.00261
更新日期:2018-06-26 00:00:00
abstract::"Chronic traumatic encephalopathy" (CTE) is described as a slowly progressive neurodegenerative disease believed to result from multiple concussions. Traditionally, concussions were considered benign events and although most people recover fully, about 10% develop a post-concussive syndrome with persisting neurologica...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2014.00030
更新日期:2014-01-31 00:00:00
abstract::The human brain uses acoustic cues to decompose complex auditory scenes into its components. For instance to improve communication, a listener can select an individual "stream," such as a talker in a crowded room, based on cues such as pitch or location. Despite numerous investigations into auditory streaming, few hav...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2012.00158
更新日期:2012-06-08 00:00:00
abstract::Objective: Genetic variation, especially polymorphism of the dopamine D4 receptor gene (DRD4), has been linked to deficits in self-regulation and executive functions and to attention deficit hyperactivity disorder (ADHD), and is related to the structural and functional integrity of the default mode network (DMN), the ...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2018.00279
更新日期:2018-07-12 00:00:00
abstract::Vestibular inputs make a key contribution to the sense of one's own spatial location. While the effects of vestibular stimulation on visuo-spatial processing in neurological patients have been extensively described, the normal contribution of vestibular inputs to spatial perception remains unclear. To address this iss...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2013.00660
更新日期:2013-10-10 00:00:00
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journal_title:Frontiers in human neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnhum.2015.00101
更新日期:2015-02-27 00:00:00
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journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2014.00409
更新日期:2014-06-10 00:00:00