Abstract：
:Indoline framework is often perpended as a privileged heterocycle present in medicinally valuable compounds of natural and synthetic origin. This review article presents the rational approaches/strategies employed for the design of anticancer indolines along with the structure activity relationship and mechanistic insights revealed in the in-vitro and in-vivo assays. The chemist has always been fascinated towards the indoline ring for the construction of antitumor scaffolds owing to its versatility as evidenced by its existence in scaffolds inducing antiproliferative effects via diverse mechanisms. To the delight of medicinal chemist, the applicability of indoline has also been expanded towards the design of dual inhibitors (multitargeting anticancer agents) as well as PROTACS. Overall, it can be concluded that indoline moiety is a magic bullet and the scaffolds containing this ring are foraying towards detailed preclinical and clinical stage investigations by leaps and bounds.
journal_name
Bioorg Chemjournal_title
Bioorganic chemistryauthors
Thakur A,Singh A,Kaur N,Ojha R,Nepali Kdoi
10.1016/j.bioorg.2019.103436subject
Has Abstractpub_date
2020-01-01 00:00:00pages
103436eissn
0045-2068issn
1090-2120pii
S0045-2068(19)31250-7journal_volume
94pub_type
杂志文章,评审abstract：:Starting from the molecular simplification of (R) 4-(3,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide 9a, a compound endowed with selectivity for human Carbonic Anhydrase (hCA) IV, a series of piperazines and 4-aminopiperidines carrying a 4-sulfamoylbenzamide moiety as Zn-binding group have been designed and teste...
journal_title：Bioorganic chemistry
pub_type： 杂志文章
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journal_title：Bioorganic chemistry
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journal_title：Bioorganic chemistry
pub_type： 杂志文章,评审
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journal_title：Bioorganic chemistry
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pub_type： 杂志文章
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journal_title：Bioorganic chemistry
pub_type： 杂志文章,评审
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journal_title：Bioorganic chemistry
pub_type： 杂志文章
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journal_title：Bioorganic chemistry
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更新日期：2018-02-01 00:00:00
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pub_type： 杂志文章
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journal_title：Bioorganic chemistry
pub_type： 杂志文章
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更新日期：2019-11-01 00:00:00
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journal_title：Bioorganic chemistry
pub_type： 杂志文章
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更新日期：2019-03-01 00:00:00
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journal_title：Bioorganic chemistry
pub_type： 杂志文章
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更新日期：2019-08-01 00:00:00
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journal_title：Bioorganic chemistry
pub_type： 杂志文章
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更新日期：2020-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-06-01 00:00:00
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journal_title：Bioorganic chemistry
pub_type： 杂志文章
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更新日期：2020-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2003-08-01 00:00:00
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journal_title：Bioorganic chemistry
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pub_type： 杂志文章
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更新日期：2017-10-01 00:00:00
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更新日期：2021-01-01 00:00:00
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journal_title：Bioorganic chemistry
pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
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journal_title：Bioorganic chemistry
pub_type： 杂志文章
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更新日期：2018-04-01 00:00:00
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更新日期：2020-06-01 00:00:00
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journal_title：Bioorganic chemistry
pub_type： 杂志文章
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更新日期：2020-10-01 00:00:00
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journal_title：Bioorganic chemistry
pub_type： 杂志文章,评审
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更新日期：2014-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-05-01 00:00:00
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journal_title：Bioorganic chemistry
pub_type： 杂志文章
doi：10.1016/j.bioorg.2008.11.001
更新日期：2009-02-01 00:00:00
