Abstract：
:Steroids are polycyclic compounds that have a wide range of biological activities. They are bio-synthesized from cholesterol through a series of enzyme-mediated transformations, so they are highly lipophilic and readily enter most cells to interact with intracellular receptors, making them ideal vehicles for targeting a broad array of pathologies. New curative agents for cancers have been developed from several steroidal derivatives. Some biologically important properties of modified steroids are dependent on structural features of the steroid moiety and their side chains. Therefore, chemical derivatization of steroids provides a way to modify their function, and many structure-activity relationships have been confirmed by such synthetic modifications. Several studies demonstrate that steroidal heterocyclic derivatives can be effective in the prevention and treatment of many types of hormone-dependent cancers. The present review is a concise report on steroidal heterocyclic derivatives, with special emphasis on steroid heterocyclic derivatives with 5 membered rings or six-membered rings having interesting therapeutic potential as enzyme inhibitors and cytotoxic drugs to be used as candidates for anti-cancer drug development.
journal_name
Bioorg Chemjournal_title
Bioorganic chemistryauthors
Tantawy MA,Nafie MS,Elmegeed GA,Ali IAIdoi
10.1016/j.bioorg.2017.06.006subject
Has Abstractpub_date
2017-08-01 00:00:00pages
128-146eissn
0045-2068issn
1090-2120pii
S0045-2068(17)30257-2journal_volume
73pub_type
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