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Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS.

Abstract：

:A phytochemical study to obtain new nitric oxide (NO) inhibitors resulted in the isolation of five new withanolides from the whole plants of Physalis peruviana. The structures were determined on the basis of extensive NMR spectroscopic data analysis as well as the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The NO inhibitory effects were examined by inhibiting NO release in lipopolysaccharide-stimulated murine microglial BV-2 cells. Molecular docking studies showed the strong interactions of bioactive compounds with the inducible nitric oxide synthase (iNOS) protein, revealing the potential mechanism of NO inhibition of bioactive compounds.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Dong B,An L,Yang X,Zhang X,Zhang J,Tuerhong M,Jin DQ,Ohizumi Y,Lee D,Xu J,Guo Y

doi

10.1016/j.bioorg.2019.03.051

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

585-593

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(18)31546-3

journal_volume

87

pub_type

杂志文章

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