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Ellagitannin and flavonoid constituents from Agrimonia pilosa Ledeb. with their protein tyrosine phosphatase and acetylcholinesterase inhibitory activities.

Abstract：

:A new ellagitannin, agritannin (1), a new flavone glycoside, agriflavone (2), and another flavone glycoside with spectroscopic data reported for the first time, kaempferol-3-O-[(S)-3-hydroxy-3-methylglutaryl (1→6)]-β-d-glucoside (3), along with 16 known compounds were isolated from the aerial parts of Agrimonia pilosa Ledeb. These compounds were evaluated for PTP1B inhibitory activity. Among them, compounds 9 and 18 displayed potential inhibitory activity against PTP1B with IC50 values of 7.14±1.75 and 7.73±0.24μM, respectively. In addition, compound 1 showed significant inhibitory effect with an IC50 value of 17.03±0.09μM. Furthermore, these compounds were tested in AChE inhibitory assays. Most of them were found to have moderate inhibitory effects, with IC50 values ranging from 60.20±1.09 to 92.85±1.12μM. Except compounds 3, 8, and 18 were inactive.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Nguyen DH,Seo UM,Zhao BT,Le DD,Seong SH,Choi JS,Min BS,Woo MH

doi

10.1016/j.bioorg.2017.04.017

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

293-300

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(17)30014-7

journal_volume

72

pub_type

杂志文章

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