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Multi-target 1,4-dihydropyridines showing calcium channel blockade and antioxidant capacity for Alzheimer's disease therapy.

Abstract：

:In this work we describe the synthesis, Ca+2 channel blockade capacity and antioxidant power of N3,N5-bis(2-(5-methoxy-1H-indol-3-yl)ethyl)-2,6-dimethyl-4-aryl-1,4-dihydropyridine-3,5-dicarboxamides 1-9, a number of multi-target small 1,4-dihydropyridines (DHP), designed by juxtaposition of melatonin and nimodipine. As a result, we have identified antioxidant DHP 7 (Ca2+ channel blockade: 55%, and 8.78 Trolox/Equivalents), the most balanced DHP analyzed here, for potential Alzheimer's disease therapy.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Malek R,Maj M,Wnorowski A,Jóźwiak K,Martin H,Iriepa I,Moraleda I,Chabchoub F,Marco-Contelles J,Ismaili L

doi

10.1016/j.bioorg.2019.103205

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

103205

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(19)30841-7

journal_volume

91

pub_type

杂志文章

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