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2,4-Diketo esters: Crucial intermediates for drug discovery.

Abstract：

:Convenient structures such as 2,4-diketo esters have been widely used as an effective pattern in medicinal chemistry and pharmacology for drug discovery. 2,4-Diketonate is a common scaffold that can be found in many biologically active and naturally occurring compounds. Also, many 2,4-diketo ester derivatives have been prepared due to their suitable synthesis. These synthetic drugs and natural products have shown numerous interesting biological properties with clinical potential as a cure for the broad specter of diseases. This review aims to highlight the important evidence of 2,4-diketo esters as a privileged scaffold in medicinal chemistry and pharmacology. Herein, numerous aspects of 2,4-diketo esters will be summarized, including synthesis and isolation of their derivatives, development of novel synthetic methodologies, the evaluation of their biological properties as well as the mechanisms of action of the diketo ester derivates. This paperwork is expected to be a comprehensive, trustworthy, and critical review of the 2,4-diketo ester intermediate to the chemistry community.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Joksimović N,Janković N,Davidović G,Bugarčić Z

doi

10.1016/j.bioorg.2020.104343

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

104343

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(20)31641-2

journal_volume

105

pub_type

杂志文章,评审

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