Abstract:
:Euphoroids A-C (1-3), three new ent-abietane-type diterpenoids, together with ten known analogues (4-13) were obtained from the roots of Euphorbia ebracteolata. The structures of these compounds were determined by extensive spectroscopic data analysis, including UV, HRESIMS, 1D-, and 2D-NMR data. The inhibitory effects of compounds 1-13 on human cancer cells were determined using the MTT assay. The results revealed that new compounds 2 and 3 showed moderate cytotoxic activities against human cancer cell lines. Especially, compound 3 displayed selective cytotoxic effect agains cancer cell lines.
journal_name
Bioorg Chemjournal_title
Bioorganic chemistryauthors
Han C,Peng Y,Wang Y,Huo X,Zhang B,Li D,Leng A,Zhang H,Ma X,Wang Cdoi
10.1016/j.bioorg.2018.07.032subject
Has Abstractpub_date
2018-12-01 00:00:00pages
93-97eissn
0045-2068issn
1090-2120pii
S0045-2068(18)30638-2journal_volume
81pub_type
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