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Synthesis and antiproliferative activity of new 2-glyco-3-nitro-2H-chromenes.

Abstract：

:3-nitro-2H-chromenes and derivatives are compounds with diverse biological activity, among them, new 2-glyco-3-nitro-2H-chromenes have been prepared by one-pot oxa-Michael-Henry-dehydration reactions between carbohydrate-derived nitroalkenes and several salicylaldehydes, using a minimal amount of solvent and DBU as catalyst. The antiproliferative activity of these new compounds has been evaluated against a panel of six human solid tumor cell lines, and compared to pharmacological reference compounds, finding that their activities are in the low micromolar range and that some of them are more effective than the standards.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Luque-Agudo V,Albarrán-Velo J,Light ME,Padrón JM,Román E,Serrano JA,Gil MV

doi

10.1016/j.bioorg.2019.03.016

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

112-116

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(19)30069-0

journal_volume

87

pub_type

杂志文章

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