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Targeted dendrimers for antagonizing the migration and viability of NALM-6 lymphoblastic leukemia cells.

Abstract：

:Acute lymphoblastic leukemia (ALL) or white blood cell cancer is one of the major causes that kills many children worldwide. Although various therapeutic agents are available for ALL treatment, the new drug discovery and drug delivery system are needed to improve their effectiveness, to reduce the toxicity and side-effect, and to enhance their selectivity to target cancer cells. CXCR4 is a protein expressed on the surface of various types of cancer cell including ALL. In this work, the CXCR4-targeted PAMAM dendrimer was constructed by conjugating G5 PAMAM with a CXCR4 antagonist, LFC131. The results revealed that the LFC131-conjugated G5 PAMAM selectively targeted CXCR4 expressing leukemic precursor B cells (NALM-6) and the migration of NALM-6 cells induced by SDF-1α was inhibited at non-cytotoxic concentration. Further research based on this findings may contribute to potential anti-metastatic drugs for lymphoblastic leukemia.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Chittasupho C,Aonsri C,Imaram W

doi

10.1016/j.bioorg.2020.104601

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

104601

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(20)31899-X

journal_volume

107

pub_type

杂志文章

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