Abstract:
:Acute lymphoblastic leukemia (ALL) or white blood cell cancer is one of the major causes that kills many children worldwide. Although various therapeutic agents are available for ALL treatment, the new drug discovery and drug delivery system are needed to improve their effectiveness, to reduce the toxicity and side-effect, and to enhance their selectivity to target cancer cells. CXCR4 is a protein expressed on the surface of various types of cancer cell including ALL. In this work, the CXCR4-targeted PAMAM dendrimer was constructed by conjugating G5 PAMAM with a CXCR4 antagonist, LFC131. The results revealed that the LFC131-conjugated G5 PAMAM selectively targeted CXCR4 expressing leukemic precursor B cells (NALM-6) and the migration of NALM-6 cells induced by SDF-1α was inhibited at non-cytotoxic concentration. Further research based on this findings may contribute to potential anti-metastatic drugs for lymphoblastic leukemia.
journal_name
Bioorg Chemjournal_title
Bioorganic chemistryauthors
Chittasupho C,Aonsri C,Imaram Wdoi
10.1016/j.bioorg.2020.104601subject
Has Abstractpub_date
2021-01-01 00:00:00pages
104601eissn
0045-2068issn
1090-2120pii
S0045-2068(20)31899-Xjournal_volume
107pub_type
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