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Bioactive seco-abietane rearranged diterpenoids from the aerial parts of Salvia prionitis.

Abstract：

:Five previously undescribed 4,5-seco-abietane rearrange diterpenoids (1-5, Prionidipene A-E) were isolated from the aerial parts of Salvia prionitis, along with thirteen known seco-abietane diterpenoids (6-18). The structures of 1-5 were elucidated mainly based on analysis of NMR and MS data. The absolute configurations of 1-3 were determined by evaluation of experimental and calculated electronic circular dichroism (ECD) spectra. Putative biosynthetic pathways toward the formation of 1 and 2 are proposed. The nitric oxide (NO) production inhibitory effects of all isolates in lipopolysaccharide (LPS)-induced in RAW 264.7 cells were evaluated. Interestingly, compounds 4 and 9 with a furan-ring showed potent inhibitory activity with IC50 values of 14.56 and 15.11 μM, respectively.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Li L,Zhou M,Xue G,Wang W,Zhou X,Wang X,Kong L,Luo J

doi

10.1016/j.bioorg.2018.08.040

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

454-460

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(18)30784-3

journal_volume

81

pub_type

杂志文章

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