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Mechanism and applications of phosphite dehydrogenase.

Abstract：

:Phosphite dehydrogenase catalyzes the NAD+-dependent oxidation of hydrogen phosphonate (common name phosphite) to phosphate in what amounts to a formal phosphoryl transfer reaction from hydride to hydroxide. This review places the enzyme in the context of phosphorus redox metabolism in nature and discusses the results of mechanistic investigations into its reaction mechanism. The potential of the enzyme as a NAD(P)H cofactor regeneration system is discussed as well as efforts to engineer the cofactor specificity of the protein.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Relyea HA,van der Donk WA

doi

10.1016/j.bioorg.2005.01.003

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

171-89

issue

3

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(05)00016-7

journal_volume

33

pub_type

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