Abstract：
:Suntamide A (1), a new cyclic peptide, was isolated from Cicadidae Periostracum. The gross structure of 1 was elucidated by detailed analysis of HRMS and 1D/2D NMR spectra, and the absolute configuration was established by C3 Marfey's method. We extended our study to examine biological activity of 1, and found that 1 protected SH-SY5Y cells against rotenone-induced neurotoxicity. This effect of 1 seemed to be attributed to antioxidant induction and protection of mitochondria from rotenone-caused injury. Along with augmentation of the antioxidant system by 1, there was an evident activation of Nrf2, a transcription factor involved in the activation of the antioxidant system. These results indicate that 1 rescued the cells from rotenone-mediated neurotoxicity by enhancing antioxidant capacity via induction of Nrf2, suggesting that the compound could be used as a therapeutic intervention in neurodegenerative diseases such as Parkinson's disease.
journal_name
Bioorg Chemjournal_title
Bioorganic chemistryauthors
Thapa P,Katila N,Choi DY,Choi H,Nam JWdoi
10.1016/j.bioorg.2020.104493subject
Has Abstractpub_date
2021-01-01 00:00:00pages
104493eissn
0045-2068issn
1090-2120pii
S0045-2068(20)31791-0journal_volume
106pub_type
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