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[12]aneN3-based lipid with naphthalimide moiety for enhanced gene transfection efficiency.

Abstract：

:Three cationic lipids derived from [12]aneN3 modified with naphthalimide (1a), oleic acid (1b) and octadecylamine (1c) were designed and synthesized. In vitro transfection showed that all these liposomes can deliver plasmid DNA into the tested cell lines. Among these liposomes, 1a gave the best transfection efficiency (TE) in A549 cells, which was higher than that of lipofectamine 2000. More importantly, the TE of 1a was dramatically increased in the presence of 10% serum. These results suggested that 1a might be a promising non-viral gene vector, and also give further insight for developing novel high performance gene delivery agents.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Gao YG,Alam U,Ding AX,Tang Q,Tan ZL,Shi YD,Lu ZL,Qian AR

doi

10.1016/j.bioorg.2018.04.018

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

334-340

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(18)30256-6

journal_volume

79

pub_type

杂志文章

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