Abstract：
:Ring-C of oleanolic acid was chemically modified by treating with NBS under a variety of experimental conditions. The structures of the synthesized compounds were established by spectral analysis ((1)H &(13)C NMR and Mass). All the compounds were evaluated against a panel of five human cancer cell lines by using MTT assay. Among the tested compounds, 2 and 7 showed significant activity against breast cancer cell line, MCF-7. Most significantly, compound 7 showed several folds enhanced activity against MCF-7 cancer cell lines (IC50: 2.96μM) than that of the parent (1) and the intermediate compound (6). Flow cytometric analysis revealed that these compounds arrested the cell cycle in G0/G1 phase and induced mitochondrial mediated apoptosis.
journal_name
Bioorg Chemjournal_title
Bioorganic chemistryauthors
Pattnaik B,Lakshma Nayak V,Ramakrishna S,Venkata Mallavadhani Udoi
10.1016/j.bioorg.2016.08.001subject
Has Abstractpub_date
2016-10-01 00:00:00pages
152-8eissn
0045-2068issn
1090-2120pii
S0045-2068(16)30191-2journal_volume
68pub_type
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