New heterocyclic compounds from Ranunculus ternatus Thunb.

Abstract:

:Five new heterocyclic compounds, 5-α-d-fructofuranosylmethyl-furfural (1), 5-β-d-fructofuranosylmethyl-furfural (2), 5-β-d-fructopyranosylmethyl-furfural (3), 4-(2-((2S-2,3-dihydroxypropoxy)methyl)-5-formyl-1H-pyrrol-1-yl)butanoic acid (4), and 3S,4S-4,5,8-trihydroxy-3-(prop-1-en-2-yl)isochroman-1-one (5), were obtained from the root of Ranunculus ternatus Thunb., which is a traditional Chinese anti-tuberculosis medicine. Their structures were elucidated by UV, IR, HRESIMS, NMR data, and the comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Notably, compounds 1-3 are rarely occurring furfural fructosides in natural sources. These heterocyclic compounds could be further studied for the synthetic chemists and pharmacologists due to the source and structural properties.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Feng ZM,Zhan ZL,Yang YN,Jiang JS,Zhang PC

doi

10.1016/j.bioorg.2017.07.004

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

10-14

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(17)30363-2

journal_volume

74

pub_type

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