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Enzymatic mechanisms for catalysis of enolization: ketosteroid isomerase.

Abstract：

:Breaking a carbon-hydrogen bond adjacent to a carbonyl is a slow step in a large number of chemical reactions. However, many enzymes are capable of catalyzing this reaction with great efficiency. One of the most proficient of these enzymes is 3-oxo-Delta5-steroid isomerase (KSI), which catalyzes the isomerization of a wide variety of 3-oxo-Delta5-steroids to their Delta4-conjugated isomers. In this review, the mechanism of KSI is discussed, with particular emphasis on energetic considerations. Both experimental and theoretical approaches are considered to explain the mechanistic details of the reaction.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Pollack RM

doi

10.1016/j.bioorg.2004.06.005

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

341-53

issue

5

eissn

0045-2068

issn

1090-2120

pii

S0045206804000550

journal_volume

32

pub_type

杂志文章,评审

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