Abstract：
:The fungus Mucor circinelloides exhibits high potential for green chemistry and technological applications. Recently M. circinelloides, which so far was considered mainly as a platform for biodiesel production, was found to exhibit high ene-reductase activity. In our current research we applied this promising microorganism to the biotransformation of a series of α,β-unsaturated γ-ketophosphonates. The biotransformations were conducted using cheap corn steep liquor or minimal media. The products were obtained with excellent enantiomeric purity (>99% ee in most cases) and in good isolated yields, highlighting the great potential of this microorganism for asymmetric synthesis. Moreover, the products obtained may be further applied as chiral building blocks for the synthesis of biologically active compounds, such as glutamic acid or fosmidomycin derivatives.
journal_name
Bioorg Chemjournal_title
Bioorganic chemistryauthors
Janicki I,Kiełbasiński P,Szeląg J,Głębski A,Szczęsna-Antczak Mdoi
10.1016/j.bioorg.2019.103548subject
Has Abstractpub_date
2020-03-01 00:00:00pages
103548eissn
0045-2068issn
1090-2120pii
S0045-2068(19)31830-9journal_volume
96pub_type
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