当前位置： SCI文献检索 > BIOORGANIC CHEMISTRY期刊下所有文献 > Evaluation of andrographolide-based analogs derived from Andrographis paniculata against Mythimna separata Walker and Tetranychus cinnabarinus Boisduval.

Evaluation of andrographolide-based analogs derived from Andrographis paniculata against Mythimna separata Walker and Tetranychus cinnabarinus Boisduval.

Abstract：

:To discover new natural-product-based pesticides, we structurally modified andrographolide, a labdane diterpenoid isolated from Andrographis paniculata, and stereoselectively prepared a series of 12α-(substituted)benzylamino-14-deoxyandrographolide derivatives (I-V). Three-dimensional structures of compounds 3c, 3d, IIIa and IIIb were further determined by single-crystal X-ray diffraction. Compounds IIa (R1 = n-C3H7, R2 = PhCH2) exhibited more promising insecticidal activity against Mythimna separata than toosendanin. Compounds 3a (R1 = H), Ib (R1 = H, R2 = 4-ClPhCH2), and IVa (R1 = 4-ClPh, R2 = PhCH2) showed potent acaricidal activity against Tetranychus cinnabarinus.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Xu M,Xu J,Hao M,Zhang K,Lv M,Xu H

doi

10.1016/j.bioorg.2019.01.020

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

28-33

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(18)30939-8

journal_volume

86

pub_type

杂志文章

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