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Bioactive polyoxygenated seco-cyclohexenes from Artabotrys hongkongensis.

Abstract：

:Six new polyoxygenated seco-cyclohexenes, artahongkongenes A-F (1-6), together with six known analogues (7-12) were isolated from the stems and leaves of Artabotrys hongkongensis. Their structures were elucidated by extensive spectroscopic methods. All new compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. New seco-cyclohexenes 1-6 showed significant inhibitory effects against various human cancer cell lines with IC50 values ranging from 0.26 to 16.58 μM.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Liu YP,Tang JY,Hua Y,Lai L,Luo XL,Zhang ZJ,Yin WQ,Chen GY,Fu YH

doi

10.1016/j.bioorg.2017.12.011

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

386-391

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(17)30724-1

journal_volume

76

pub_type

杂志文章

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