Abstract:
:Six new polyoxygenated seco-cyclohexenes, artahongkongenes A-F (1-6), together with six known analogues (7-12) were isolated from the stems and leaves of Artabotrys hongkongensis. Their structures were elucidated by extensive spectroscopic methods. All new compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. New seco-cyclohexenes 1-6 showed significant inhibitory effects against various human cancer cell lines with IC50 values ranging from 0.26 to 16.58 μM.
journal_name
Bioorg Chemjournal_title
Bioorganic chemistryauthors
Liu YP,Tang JY,Hua Y,Lai L,Luo XL,Zhang ZJ,Yin WQ,Chen GY,Fu YHdoi
10.1016/j.bioorg.2017.12.011subject
Has Abstractpub_date
2018-02-01 00:00:00pages
386-391eissn
0045-2068issn
1090-2120pii
S0045-2068(17)30724-1journal_volume
76pub_type
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